(26 nodes) Positive regulation of type I interferon-mediated signaling pathway network (Heterocephalus glaber)

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Known Interactions

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Predicted Interactions

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Your Input:
	GW7_04978	Ubiquitin-conjugating enzyme E2 K. (97 aa)
	TBK1	Serine/threonine-protein kinase TBK1. (729 aa)
	GW7_00198	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
	Zbp1	Z-DNA-binding protein 1. (532 aa)
	GW7_19703	Ubiquitin-conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (141 aa)
	GW7_17027	Ubiquitin-conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (207 aa)
	Trim56	Tripartite motif-containing protein 56. (739 aa)
	Tmem173	Transmembrane protein 173. (378 aa)
	Mavs	Mitochondrial antiviral-signaling protein. (574 aa)
	Trim41	E3 ubiquitin-protein ligase TRIM 41. (616 aa)
	GW7_15298	Interferon regulatory factor 3. (373 aa)
	Irf3	Interferon regulatory factor 3. (415 aa)
	RNF185	E3 ubiquitin-protein ligase RNF185 isoform 1. (192 aa)
	GW7_17130	LSM14-like protein A. (407 aa)
	USP27X	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (438 aa)
	GW7_06305	LSM14-like protein A. (231 aa)
	GW7_15589	Ubiquitin-conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (188 aa)
	GW7_07568	Inhibitor of nuclear factor kappa-B kinase subunit epsilon. (691 aa)
	Nlrc5	Protein NLRC5. (1868 aa)
	Trim6	Tripartite motif-containing protein 6. (485 aa)
	Fadd	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (197 aa)
	GW7_06309	LSM14-like protein A. (451 aa)
	Mmp12	Macrophage metalloelastase. (403 aa)
	Lsm14a	LSM14-like protein A. (430 aa)
	Irf7	Interferon regulatory factor 7. (440 aa)
	GW7_14956	LSM14-like protein A. (243 aa)

Your Current Organism:

Heterocephalus glaber

NCBI taxonomy Id: 10181
Other names: H. glaber, naked mole rat, naked mole-rat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Fadd	Mavs	G5BSS5	G5B4V0	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Mitochondrial antiviral-signaling protein.	0.645
Fadd	TBK1	G5BSS5	G5ARJ7	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Serine/threonine-protein kinase TBK1.	0.471
Fadd	Zbp1	G5BSS5	G5AUM6	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Z-DNA-binding protein 1.	0.419
GW7_07568	GW7_15298	G5BP26	G5B8Q1	Inhibitor of nuclear factor kappa-B kinase subunit epsilon.	Interferon regulatory factor 3.	0.886
GW7_07568	Irf3	G5BP26	G5B8Q2	Inhibitor of nuclear factor kappa-B kinase subunit epsilon.	Interferon regulatory factor 3.	0.886
GW7_07568	Irf7	G5BP26	G5C485	Inhibitor of nuclear factor kappa-B kinase subunit epsilon.	Interferon regulatory factor 7.	0.724
GW7_07568	Mavs	G5BP26	G5B4V0	Inhibitor of nuclear factor kappa-B kinase subunit epsilon.	Mitochondrial antiviral-signaling protein.	0.982
GW7_07568	TBK1	G5BP26	G5ARJ7	Inhibitor of nuclear factor kappa-B kinase subunit epsilon.	Serine/threonine-protein kinase TBK1.	0.990
GW7_07568	Tmem173	G5BP26	G5AZ76	Inhibitor of nuclear factor kappa-B kinase subunit epsilon.	Transmembrane protein 173.	0.935
GW7_07568	Zbp1	G5BP26	G5AUM6	Inhibitor of nuclear factor kappa-B kinase subunit epsilon.	Z-DNA-binding protein 1.	0.491
GW7_15298	GW7_07568	G5B8Q1	G5BP26	Interferon regulatory factor 3.	Inhibitor of nuclear factor kappa-B kinase subunit epsilon.	0.886
GW7_15298	Irf7	G5B8Q1	G5C485	Interferon regulatory factor 3.	Interferon regulatory factor 7.	0.814
GW7_15298	Mavs	G5B8Q1	G5B4V0	Interferon regulatory factor 3.	Mitochondrial antiviral-signaling protein.	0.863
GW7_15298	TBK1	G5B8Q1	G5ARJ7	Interferon regulatory factor 3.	Serine/threonine-protein kinase TBK1.	0.937
GW7_15298	Tmem173	G5B8Q1	G5AZ76	Interferon regulatory factor 3.	Transmembrane protein 173.	0.896
GW7_15298	Zbp1	G5B8Q1	G5AUM6	Interferon regulatory factor 3.	Z-DNA-binding protein 1.	0.485
GW7_17027	GW7_19703	G5AVR4	G5AV99	Ubiquitin-conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family.	0.901
GW7_19703	GW7_17027	G5AV99	G5AVR4	Ubiquitin-conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family.	0.901
Irf3	GW7_07568	G5B8Q2	G5BP26	Interferon regulatory factor 3.	Inhibitor of nuclear factor kappa-B kinase subunit epsilon.	0.886
Irf3	Irf7	G5B8Q2	G5C485	Interferon regulatory factor 3.	Interferon regulatory factor 7.	0.980