(20 nodes) NAD+ binding network (Heterocephalus glaber)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

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Your Input:
	Glud1	Glutamate dehydrogenase 1, mitochondrial; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (550 aa)
	HPGD	15-hydroxyprostaglandin dehydrogenase (NAD(+)) isoform 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
	Sirt2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
	GW7_17857	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial. (453 aa)
	GW7_19281	Aldehyde dehydrogenase family 1 member A3; Belongs to the aldehyde dehydrogenase family. (538 aa)
	Sirt3	NAD-dependent deacetylase sirtuin-3, mitochondrial. (300 aa)
	Sirt4	NAD-dependent ADP-ribosyltransferase sirtuin-4. (313 aa)
	Sirt1	NAD-dependent deacetylase sirtuin-1. (401 aa)
	GW7_04066	NAD-dependent deacetylase sirtuin-1. (198 aa)
	Sirt7	NAD-dependent deacetylase sirtuin-7. (400 aa)
	Cryl1	Lambda-crystallin-like protein. (306 aa)
	GW7_19340	NAD-dependent deacetylase sirtuin-1. (105 aa)
	SIRT5	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (309 aa)
	Ehhadh	Peroxisomal bifunctional enzyme; Belongs to the enoyl-CoA hydratase/isomerase family. (714 aa)
	GW7_09559	UDP-glucuronic acid decarboxylase 1. (218 aa)
	Sirt6	NAD-dependent protein deacetylase sirtuin-6. (350 aa)
	GW7_09992	Glutamate dehydrogenase 1, mitochondrial. (186 aa)
	GW7_01495	Glutamate dehydrogenase 1, mitochondrial. (245 aa)
	GW7_05145	UDP-glucuronic acid decarboxylase 1. (443 aa)
	HADHA	Trifunctional enzyme subunit alpha, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)

Your Current Organism:

Heterocephalus glaber

NCBI taxonomy Id: 10181
Other names: H. glaber, naked mole rat, naked mole-rat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cryl1	Ehhadh	G5BKV7	G5BTB0	Lambda-crystallin-like protein.	Peroxisomal bifunctional enzyme; Belongs to the enoyl-CoA hydratase/isomerase family.	0.514
Cryl1	HADHA	G5BKV7	G5CBK7	Lambda-crystallin-like protein.	Trifunctional enzyme subunit alpha, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family.	0.514
Ehhadh	Cryl1	G5BTB0	G5BKV7	Peroxisomal bifunctional enzyme; Belongs to the enoyl-CoA hydratase/isomerase family.	Lambda-crystallin-like protein.	0.514
Ehhadh	GW7_17857	G5BTB0	G5AQL0	Peroxisomal bifunctional enzyme; Belongs to the enoyl-CoA hydratase/isomerase family.	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial.	0.650
Ehhadh	HADHA	G5BTB0	G5CBK7	Peroxisomal bifunctional enzyme; Belongs to the enoyl-CoA hydratase/isomerase family.	Trifunctional enzyme subunit alpha, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family.	0.933
GW7_01495	GW7_04066	G5C9M4	G5BJ51	Glutamate dehydrogenase 1, mitochondrial.	NAD-dependent deacetylase sirtuin-1.	0.432
GW7_01495	GW7_19340	G5C9M4	G5BL74	Glutamate dehydrogenase 1, mitochondrial.	NAD-dependent deacetylase sirtuin-1.	0.432
GW7_01495	SIRT5	G5C9M4	G5BN47	Glutamate dehydrogenase 1, mitochondrial.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...]	0.442
GW7_01495	Sirt1	G5C9M4	G5B7Y9	Glutamate dehydrogenase 1, mitochondrial.	NAD-dependent deacetylase sirtuin-1.	0.432
GW7_01495	Sirt2	G5C9M4	G5AMA2	Glutamate dehydrogenase 1, mitochondrial.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.431
GW7_01495	Sirt3	G5C9M4	G5AUC0	Glutamate dehydrogenase 1, mitochondrial.	NAD-dependent deacetylase sirtuin-3, mitochondrial.	0.451
GW7_01495	Sirt4	G5C9M4	G5B780	Glutamate dehydrogenase 1, mitochondrial.	NAD-dependent ADP-ribosyltransferase sirtuin-4.	0.666
GW7_01495	Sirt6	G5C9M4	G5BZB2	Glutamate dehydrogenase 1, mitochondrial.	NAD-dependent protein deacetylase sirtuin-6.	0.443
GW7_01495	Sirt7	G5C9M4	G5BJ83	Glutamate dehydrogenase 1, mitochondrial.	NAD-dependent deacetylase sirtuin-7.	0.442
GW7_04066	GW7_01495	G5BJ51	G5C9M4	NAD-dependent deacetylase sirtuin-1.	Glutamate dehydrogenase 1, mitochondrial.	0.432
GW7_04066	GW7_09992	G5BJ51	G5C6Z4	NAD-dependent deacetylase sirtuin-1.	Glutamate dehydrogenase 1, mitochondrial.	0.432
GW7_04066	Glud1	G5BJ51	G5ATF9	NAD-dependent deacetylase sirtuin-1.	Glutamate dehydrogenase 1, mitochondrial; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.432
GW7_04066	Sirt2	G5BJ51	G5AMA2	NAD-dependent deacetylase sirtuin-1.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.530
GW7_04066	Sirt3	G5BJ51	G5AUC0	NAD-dependent deacetylase sirtuin-1.	NAD-dependent deacetylase sirtuin-3, mitochondrial.	0.616
GW7_04066	Sirt6	G5BJ51	G5BZB2	NAD-dependent deacetylase sirtuin-1.	NAD-dependent protein deacetylase sirtuin-6.	0.498