(17 nodes) Nephron tubule formation network (Heterocephalus glaber)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Nog	Noggin. (184 aa)
	Wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
	Ctnnb1	Catenin beta-1. (944 aa)
	Sox9	Transcription factor SOX-9. (507 aa)
	Osr1	Protein odd-skipped-related 1. (267 aa)
	Hnf1b	Hepatocyte nuclear factor 1-beta. (557 aa)
	Pax8	Paired box protein Pax-8. (483 aa)
	Hs2st1	Heparan sulfate 2-O-sulfotransferase 1. (283 aa)
	Wnt9b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
	Irx2	Iroquois-class homeodomain protein IRX-2. (262 aa)
	Gata3	Trans-acting T-cell-specific transcription factor GATA-3. (444 aa)
	GW7_06032	Iroquois-class homeodomain protein irx-3. (433 aa)
	Gdnf	Glial cell line-derived neurotrophic factor. (187 aa)
	GREM1	Gremlin. (184 aa)
	Sox8	Transcription factor SOX-8. (362 aa)
	SIX1	Homeobox protein SIX1. (284 aa)
	GW7_15874	Paired box protein Pax-2. (702 aa)

Your Current Organism:

Heterocephalus glaber

NCBI taxonomy Id: 10181
Other names: H. glaber, naked mole rat, naked mole-rat

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ctnnb1	Sox8	G5ALX2	G5BXU3	Catenin beta-1.	Transcription factor SOX-8.	0.597
Ctnnb1	Sox9	G5ALX2	G5AV36	Catenin beta-1.	Transcription factor SOX-9.	0.799
Ctnnb1	Wnt6	G5ALX2	G5AKL4	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.529
Ctnnb1	Wnt9b	G5ALX2	G5BMY4	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.440
GREM1	Nog	G5BWE1	G5BPB0	Gremlin.	Noggin.	0.452
GW7_06032	Irx2	G5BSE0	G5BPI8	Iroquois-class homeodomain protein irx-3.	Iroquois-class homeodomain protein IRX-2.	0.570
GW7_15874	SIX1	G5CAE5	G5C5H8	Paired box protein Pax-2.	Homeobox protein SIX1.	0.452
Gdnf	Nog	G5BTT7	G5BPB0	Glial cell line-derived neurotrophic factor.	Noggin.	0.544
Irx2	GW7_06032	G5BPI8	G5BSE0	Iroquois-class homeodomain protein IRX-2.	Iroquois-class homeodomain protein irx-3.	0.570
Nog	GREM1	G5BPB0	G5BWE1	Noggin.	Gremlin.	0.452
Nog	Gdnf	G5BPB0	G5BTT7	Noggin.	Glial cell line-derived neurotrophic factor.	0.544
SIX1	GW7_15874	G5C5H8	G5CAE5	Homeobox protein SIX1.	Paired box protein Pax-2.	0.452
SIX1	Sox8	G5C5H8	G5BXU3	Homeobox protein SIX1.	Transcription factor SOX-8.	0.421
SIX1	Sox9	G5C5H8	G5AV36	Homeobox protein SIX1.	Transcription factor SOX-9.	0.417
Sox8	Ctnnb1	G5BXU3	G5ALX2	Transcription factor SOX-8.	Catenin beta-1.	0.597
Sox8	SIX1	G5BXU3	G5C5H8	Transcription factor SOX-8.	Homeobox protein SIX1.	0.421
Sox9	Ctnnb1	G5AV36	G5ALX2	Transcription factor SOX-9.	Catenin beta-1.	0.799
Sox9	SIX1	G5AV36	G5C5H8	Transcription factor SOX-9.	Homeobox protein SIX1.	0.417
Wnt6	Ctnnb1	G5AKL4	G5ALX2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Catenin beta-1.	0.529
Wnt6	Wnt9b	G5AKL4	G5BMY4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.591