13 items (Heterocephalus glaber) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Usp30	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (462 aa)
	GW7_03634	N_BRCA1_IG domain-containing protein. (241 aa)
	GW7_08986	Next to BRCA1 gene 1 protein. (146 aa)
	RPS27A	Ubiquitin-40S ribosomal protein S27a. (156 aa)
	Map1lc3b	Microtubule-associated proteins 1A/1B light chain 3B. (112 aa)
	Nbr1	Next to BRCA1 gene 1 protein. (968 aa)
	GW7_12569	N_BRCA1_IG domain-containing protein. (226 aa)
	Pex5l	PEX5-related protein. (583 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3055 aa)
	GW7_04997	N_BRCA1_IG domain-containing protein. (240 aa)
	Kxd1	KxDL domain-containing protein. (176 aa)
	GW7_16680	Sequestosome-1. (338 aa)
	Pex5	Peroxisomal targeting signal 1 receptor. (629 aa)

Your Current Organism:

Heterocephalus glaber

NCBI taxonomy Id: 10181
Other names: H. glaber, naked mole rat, naked mole-rat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	GW7_08986	G5BXR2	G5B4X7	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Next to BRCA1 gene 1 protein.	0.933
ATM	GW7_16680	G5BXR2	G5C7B1	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Sequestosome-1.	0.680
ATM	Map1lc3b	G5BXR2	G5BF21	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Microtubule-associated proteins 1A/1B light chain 3B.	0.477
ATM	Nbr1	G5BXR2	G5BN96	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Next to BRCA1 gene 1 protein.	0.933
ATM	Pex5	G5BXR2	G5CAS9	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Peroxisomal targeting signal 1 receptor.	0.798
ATM	Pex5l	G5BXR2	G5BX61	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	PEX5-related protein.	0.692
ATM	RPS27A	G5BXR2	G5B8W4	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ubiquitin-40S ribosomal protein S27a.	0.661
GW7_03634	GW7_08986	G5B1H3	G5B4X7	N_BRCA1_IG domain-containing protein.	Next to BRCA1 gene 1 protein.	0.458
GW7_03634	GW7_16680	G5B1H3	G5C7B1	N_BRCA1_IG domain-containing protein.	Sequestosome-1.	0.458
GW7_03634	Map1lc3b	G5B1H3	G5BF21	N_BRCA1_IG domain-containing protein.	Microtubule-associated proteins 1A/1B light chain 3B.	0.546
GW7_03634	Nbr1	G5B1H3	G5BN96	N_BRCA1_IG domain-containing protein.	Next to BRCA1 gene 1 protein.	0.458
GW7_03634	Pex5	G5B1H3	G5CAS9	N_BRCA1_IG domain-containing protein.	Peroxisomal targeting signal 1 receptor.	0.489
GW7_03634	Pex5l	G5B1H3	G5BX61	N_BRCA1_IG domain-containing protein.	PEX5-related protein.	0.489
GW7_03634	RPS27A	G5B1H3	G5B8W4	N_BRCA1_IG domain-containing protein.	Ubiquitin-40S ribosomal protein S27a.	0.556
GW7_04997	GW7_08986	G5C3W3	G5B4X7	N_BRCA1_IG domain-containing protein.	Next to BRCA1 gene 1 protein.	0.458
GW7_04997	GW7_16680	G5C3W3	G5C7B1	N_BRCA1_IG domain-containing protein.	Sequestosome-1.	0.458
GW7_04997	Map1lc3b	G5C3W3	G5BF21	N_BRCA1_IG domain-containing protein.	Microtubule-associated proteins 1A/1B light chain 3B.	0.546
GW7_04997	Nbr1	G5C3W3	G5BN96	N_BRCA1_IG domain-containing protein.	Next to BRCA1 gene 1 protein.	0.458
GW7_04997	Pex5	G5C3W3	G5CAS9	N_BRCA1_IG domain-containing protein.	Peroxisomal targeting signal 1 receptor.	0.489
GW7_04997	Pex5l	G5C3W3	G5BX61	N_BRCA1_IG domain-containing protein.	PEX5-related protein.	0.489