(57 nodes) Mixed, incl. HDR through Single Strand Annealing (SSA), and DNA damage sensor activity network (Trichoplax adhaerens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	B3RJ62_TRIAD	Uncharacterized protein. (725 aa)
	B3RJ73_TRIAD	DNA_MISMATCH_REPAIR_2 domain-containing protein. (954 aa)
	B3RJD3_TRIAD	Predicted protein. (907 aa)
	B3RJK5_TRIAD	Uncharacterized protein. (280 aa)
	B3RKZ5_TRIAD	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (841 aa)
	B3RL44_TRIAD	Uncharacterized protein. (990 aa)
	B3RLC4_TRIAD	DNA_MISMATCH_REPAIR_2 domain-containing protein. (696 aa)
	B3RLZ8_TRIAD	Rad51 domain-containing protein. (231 aa)
	B3RPL5_TRIAD	Uncharacterized protein. (1339 aa)
	B3RPR1_TRIAD	Uncharacterized protein. (1207 aa)
	B3RPU8_TRIAD	Uncharacterized protein. (832 aa)
	B3RQ77_TRIAD	Uncharacterized protein. (1383 aa)
	B3RQE9_TRIAD	Checkpoint protein; Belongs to the HUS1 family. (282 aa)
	B3RQF3_TRIAD	DNA_mis_repair domain-containing protein. (733 aa)
	B3RR01_TRIAD	BRCT domain-containing protein. (1270 aa)
	B3RSB2_TRIAD	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (625 aa)
	B3RSK0_TRIAD	Predicted protein. (1507 aa)
	B3RSS5_TRIAD	Predicted protein. (1281 aa)
	B3RSS6_TRIAD	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1095 aa)
	B3RTQ9_TRIAD	Uncharacterized protein. (1020 aa)
	B3RTU2_TRIAD	Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. (454 aa)
	B3RTZ7_TRIAD	Uncharacterized protein. (247 aa)
	B3RU80_TRIAD	RECA_2 domain-containing protein. (295 aa)
	B3RV84_TRIAD	BRCT domain-containing protein. (528 aa)
	B3RWA2_TRIAD	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
	B3RWE3_TRIAD	DNA_MISMATCH_REPAIR_2 domain-containing protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
	B3RXL1_TRIAD	Uncharacterized protein. (388 aa)
	B3RXP3_TRIAD	DUF1767 domain-containing protein. (507 aa)
	B3RZH8_TRIAD	CRT-like domain-containing protein. (305 aa)
	B3S0T1_TRIAD	Uncharacterized protein. (326 aa)
	B3S104_TRIAD	ERCC4 domain-containing protein. (846 aa)
	B3S1V8_TRIAD	Uncharacterized protein. (687 aa)
	B3S2F7_TRIAD	Uncharacterized protein. (706 aa)
	B3S2J7_TRIAD	Uncharacterized protein. (387 aa)
	B3S3R0_TRIAD	Uncharacterized protein. (160 aa)
	B3S3R6_TRIAD	DNA_MISMATCH_REPAIR_2 domain-containing protein. (907 aa)
	B3S474_TRIAD	Predicted protein. (460 aa)
	B3S4K0_TRIAD	BRCA-2_OB3 domain-containing protein. (271 aa)
	B3S4S1_TRIAD	WD_REPEATS_REGION domain-containing protein. (407 aa)
	B3S571_TRIAD	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (556 aa)
	B3S6C0_TRIAD	Helicase ATP-binding domain-containing protein. (995 aa)
	B3S6D0_TRIAD	Uncharacterized protein. (817 aa)
	B3S719_TRIAD	DUF1767 domain-containing protein. (237 aa)
	B3S7A7_TRIAD	BRCT domain-containing protein. (224 aa)
	B3S7E5_TRIAD	AAA domain-containing protein. (478 aa)
	B3S7X4_TRIAD	XPA_C domain-containing protein. (245 aa)
	B3S859_TRIAD	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (752 aa)
	B3S868_TRIAD	DNA_mis_repair domain-containing protein. (357 aa)
	B3S8S8_TRIAD	Uncharacterized protein. (237 aa)
	B3SAM4_TRIAD	Uncharacterized protein. (374 aa)
	B3SBM1_TRIAD	Uncharacterized protein. (140 aa)
	B3SCJ1_TRIAD	Uncharacterized protein. (265 aa)
	B3SD12_TRIAD	DNA_MISMATCH_REPAIR_2 domain-containing protein; Component of the post-replicative DNA mismatch repair system (MMR). (984 aa)
	B3SD91_TRIAD	Uncharacterized protein. (359 aa)
	B3SDE2_TRIAD	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1725 aa)
	B3SEU1_TRIAD	Rep-A_N domain-containing protein. (218 aa)
	B3SEY0_TRIAD	Uncharacterized protein. (863 aa)

Your Current Organism:

Trichoplax adhaerens

NCBI taxonomy Id: 10228
Other names: T. adhaerens

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B3RJ62_TRIAD	B3RJD3_TRIAD	B3RJ62	B3RJD3	Uncharacterized protein.	Predicted protein.	0.765
B3RJ62_TRIAD	B3RJK5_TRIAD	B3RJ62	B3RJK5	Uncharacterized protein.	Uncharacterized protein.	0.643
B3RJ62_TRIAD	B3RKZ5_TRIAD	B3RJ62	B3RKZ5	Uncharacterized protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.750
B3RJ62_TRIAD	B3RL44_TRIAD	B3RJ62	B3RL44	Uncharacterized protein.	Uncharacterized protein.	0.657
B3RJ62_TRIAD	B3RLC4_TRIAD	B3RJ62	B3RLC4	Uncharacterized protein.	DNA_MISMATCH_REPAIR_2 domain-containing protein.	0.597
B3RJ62_TRIAD	B3RLZ8_TRIAD	B3RJ62	B3RLZ8	Uncharacterized protein.	Rad51 domain-containing protein.	0.816
B3RJ62_TRIAD	B3RPL5_TRIAD	B3RJ62	B3RPL5	Uncharacterized protein.	Uncharacterized protein.	0.850
B3RJ62_TRIAD	B3RPR1_TRIAD	B3RJ62	B3RPR1	Uncharacterized protein.	Uncharacterized protein.	0.602
B3RJ62_TRIAD	B3RPU8_TRIAD	B3RJ62	B3RPU8	Uncharacterized protein.	Uncharacterized protein.	0.474
B3RJ62_TRIAD	B3RQ77_TRIAD	B3RJ62	B3RQ77	Uncharacterized protein.	Uncharacterized protein.	0.601
B3RJ62_TRIAD	B3RQE9_TRIAD	B3RJ62	B3RQE9	Uncharacterized protein.	Checkpoint protein; Belongs to the HUS1 family.	0.664
B3RJ62_TRIAD	B3RQF3_TRIAD	B3RJ62	B3RQF3	Uncharacterized protein.	DNA_mis_repair domain-containing protein.	0.908
B3RJ62_TRIAD	B3RR01_TRIAD	B3RJ62	B3RR01	Uncharacterized protein.	BRCT domain-containing protein.	0.584
B3RJ62_TRIAD	B3RSB2_TRIAD	B3RJ62	B3RSB2	Uncharacterized protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.958
B3RJ62_TRIAD	B3RSK0_TRIAD	B3RJ62	B3RSK0	Uncharacterized protein.	Predicted protein.	0.832
B3RJ62_TRIAD	B3RSS5_TRIAD	B3RJ62	B3RSS5	Uncharacterized protein.	Predicted protein.	0.795
B3RJ62_TRIAD	B3RSS6_TRIAD	B3RJ62	B3RSS6	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.795
B3RJ62_TRIAD	B3RTQ9_TRIAD	B3RJ62	B3RTQ9	Uncharacterized protein.	Uncharacterized protein.	0.521
B3RJ62_TRIAD	B3RTU2_TRIAD	B3RJ62	B3RTU2	Uncharacterized protein.	Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family.	0.856
B3RJ62_TRIAD	B3RTZ7_TRIAD	B3RJ62	B3RTZ7	Uncharacterized protein.	Uncharacterized protein.	0.621