(58 nodes) Mixed, incl. Regulation of actin dynamics for phagocytic cup formation, and Actin polymerization or depolymerization network (Trichoplax adhaerens)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	B3RID4_TRIAD	DUF2013 domain-containing protein. (394 aa)
	B3RIX1_TRIAD	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. (128 aa)
	B3RIX2_TRIAD	Profilin; Belongs to the profilin family. (128 aa)
	B3RJQ3_TRIAD	FH2 domain-containing protein. (706 aa)
	B3RJY8_TRIAD	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (393 aa)
	B3RK40_TRIAD	Uncharacterized protein. (201 aa)
	B3RKJ1_TRIAD	SH3 domain-containing protein. (316 aa)
	B3RL22_TRIAD	Uncharacterized protein; Belongs to the actin family. (370 aa)
	B3RL28_TRIAD	Uncharacterized protein. (331 aa)
	B3RL29_TRIAD	Uncharacterized protein. (645 aa)
	B3RMF6_TRIAD	SH3 domain-containing protein. (605 aa)
	B3RMN8_TRIAD	Uncharacterized protein. (415 aa)
	B3RN74_TRIAD	Uncharacterized protein. (499 aa)
	B3RP92_TRIAD	Uncharacterized protein. (223 aa)
	B3RPC6_TRIAD	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (144 aa)
	B3RQR0_TRIAD	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (299 aa)
	B3RR02_TRIAD	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1522 aa)
	B3RR54_TRIAD	Uncharacterized protein. (1612 aa)
	B3RR76_TRIAD	Uncharacterized protein; Belongs to the actin family. (414 aa)
	B3RRZ6_TRIAD	HP domain-containing protein. (834 aa)
	B3RS73_TRIAD	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1087 aa)
	B3RT38_TRIAD	Uncharacterized protein. (184 aa)
	B3RTG8_TRIAD	Uncharacterized protein. (406 aa)
	B3RTH0_TRIAD	Uncharacterized protein. (611 aa)
	B3RTX5_TRIAD	Uncharacterized protein. (1017 aa)
	B3RUU2_TRIAD	Uncharacterized protein. (326 aa)
	B3RW95_TRIAD	Predicted protein. (922 aa)
	B3RWD9_TRIAD	Profilin; Belongs to the profilin family. (128 aa)
	B3RWQ2_TRIAD	Uncharacterized protein. (333 aa)
	B3RX77_TRIAD	Non-muscle actin 6.2. (376 aa)
	B3RXB5_TRIAD	THUMP domain-containing protein. (293 aa)
	B3RXM3_TRIAD	Uncharacterized protein. (538 aa)
	B3RXP0_TRIAD	Uncharacterized protein. (155 aa)
	B3S078_TRIAD	WD_REPEATS_REGION domain-containing protein. (231 aa)
	B3S079_TRIAD	WD_REPEATS_REGION domain-containing protein. (353 aa)
	B3S0K8_TRIAD	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (140 aa)
	B3S128_TRIAD	Adenylyl cyclase-associated protein; Belongs to the CAP family. (441 aa)
	B3S4J4_TRIAD	Uncharacterized protein. (172 aa)
	B3S5C5_TRIAD	HP domain-containing protein. (814 aa)
	B3S5C6_TRIAD	HP domain-containing protein. (798 aa)
	B3S5E4_TRIAD	Non-muscle actin 6.2. (376 aa)
	B3S5L2_TRIAD	SH3 domain-containing protein. (1305 aa)
	B3S5N3_TRIAD	Protein kinase domain-containing protein. (252 aa)
	B3S5U5_TRIAD	Uncharacterized protein. (645 aa)
	B3S5U7_TRIAD	Uncharacterized protein. (616 aa)
	B3S651_TRIAD	Arp2/3 complex 20 kd subunit. (149 aa)
	B3S666_TRIAD	Coronin; Belongs to the WD repeat coronin family. (477 aa)
	B3S6L8_TRIAD	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2188 aa)
	B3S717_TRIAD	Uncharacterized protein. (212 aa)
	B3S718_TRIAD	FH2 domain-containing protein. (804 aa)
	B3S8G4_TRIAD	Uncharacterized protein. (469 aa)
	B3S988_TRIAD	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (373 aa)
	B3S9J3_TRIAD	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1241 aa)
	B3SAC4_TRIAD	ADF-H domain-containing protein. (208 aa)
	B3SC07_TRIAD	WH2 domain-containing protein. (282 aa)
	B3SEN7_TRIAD	Uncharacterized protein. (332 aa)
	B3SEU2_TRIAD	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (125 aa)
	actin	Actin. (376 aa)

Your Current Organism:

Trichoplax adhaerens

NCBI taxonomy Id: 10228
Other names: T. adhaerens

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B3RID4_TRIAD	B3RJY8_TRIAD	B3RID4	B3RJY8	DUF2013 domain-containing protein.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.842
B3RID4_TRIAD	B3RL22_TRIAD	B3RID4	B3RL22	DUF2013 domain-containing protein.	Uncharacterized protein; Belongs to the actin family.	0.538
B3RID4_TRIAD	B3RL28_TRIAD	B3RID4	B3RL28	DUF2013 domain-containing protein.	Uncharacterized protein.	0.515
B3RID4_TRIAD	B3RL29_TRIAD	B3RID4	B3RL29	DUF2013 domain-containing protein.	Uncharacterized protein.	0.515
B3RID4_TRIAD	B3RMF6_TRIAD	B3RID4	B3RMF6	DUF2013 domain-containing protein.	SH3 domain-containing protein.	0.677
B3RID4_TRIAD	B3RN74_TRIAD	B3RID4	B3RN74	DUF2013 domain-containing protein.	Uncharacterized protein.	0.771
B3RID4_TRIAD	B3RPC6_TRIAD	B3RID4	B3RPC6	DUF2013 domain-containing protein.	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.	0.967
B3RID4_TRIAD	B3RQR0_TRIAD	B3RID4	B3RQR0	DUF2013 domain-containing protein.	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.946
B3RID4_TRIAD	B3RR76_TRIAD	B3RID4	B3RR76	DUF2013 domain-containing protein.	Uncharacterized protein; Belongs to the actin family.	0.943
B3RID4_TRIAD	B3RT38_TRIAD	B3RID4	B3RT38	DUF2013 domain-containing protein.	Uncharacterized protein.	0.675
B3RID4_TRIAD	B3RTG8_TRIAD	B3RID4	B3RTG8	DUF2013 domain-containing protein.	Uncharacterized protein.	0.583
B3RID4_TRIAD	B3RTH0_TRIAD	B3RID4	B3RTH0	DUF2013 domain-containing protein.	Uncharacterized protein.	0.583
B3RID4_TRIAD	B3RX77_TRIAD	B3RID4	B3RX77	DUF2013 domain-containing protein.	Non-muscle actin 6.2.	0.538
B3RID4_TRIAD	B3RXB5_TRIAD	B3RID4	B3RXB5	DUF2013 domain-containing protein.	THUMP domain-containing protein.	0.467
B3RID4_TRIAD	B3RXM3_TRIAD	B3RID4	B3RXM3	DUF2013 domain-containing protein.	Uncharacterized protein.	0.467
B3RID4_TRIAD	B3S4J4_TRIAD	B3RID4	B3S4J4	DUF2013 domain-containing protein.	Uncharacterized protein.	0.938
B3RID4_TRIAD	B3S5E4_TRIAD	B3RID4	B3S5E4	DUF2013 domain-containing protein.	Non-muscle actin 6.2.	0.538
B3RID4_TRIAD	B3S651_TRIAD	B3RID4	B3S651	DUF2013 domain-containing protein.	Arp2/3 complex 20 kd subunit.	0.957
B3RID4_TRIAD	B3S988_TRIAD	B3RID4	B3S988	DUF2013 domain-containing protein.	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.934
B3RID4_TRIAD	B3S9J3_TRIAD	B3RID4	B3S9J3	DUF2013 domain-containing protein.	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	0.686