(19 nodes) Mixed, incl. Formin, FH2 domain, and Profilin network (Trichoplax adhaerens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	B3RIX1_TRIAD	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. (128 aa)
	B3RIX2_TRIAD	Profilin; Belongs to the profilin family. (128 aa)
	B3RJQ3_TRIAD	FH2 domain-containing protein. (706 aa)
	B3RK40_TRIAD	Uncharacterized protein. (201 aa)
	B3RR54_TRIAD	Uncharacterized protein. (1612 aa)
	B3RTX5_TRIAD	Uncharacterized protein. (1017 aa)
	B3RW95_TRIAD	Predicted protein. (922 aa)
	B3RWD9_TRIAD	Profilin; Belongs to the profilin family. (128 aa)
	B3S078_TRIAD	WD_REPEATS_REGION domain-containing protein. (231 aa)
	B3S079_TRIAD	WD_REPEATS_REGION domain-containing protein. (353 aa)
	B3S0K8_TRIAD	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (140 aa)
	B3S128_TRIAD	Adenylyl cyclase-associated protein; Belongs to the CAP family. (441 aa)
	B3S5E4_TRIAD	Non-muscle actin 6.2. (376 aa)
	B3S5U5_TRIAD	Uncharacterized protein. (645 aa)
	B3S5U7_TRIAD	Uncharacterized protein. (616 aa)
	B3S717_TRIAD	Uncharacterized protein. (212 aa)
	B3S718_TRIAD	FH2 domain-containing protein. (804 aa)
	B3S8G4_TRIAD	Uncharacterized protein. (469 aa)
	actin	Actin. (376 aa)

Your Current Organism:

Trichoplax adhaerens

NCBI taxonomy Id: 10228
Other names: T. adhaerens

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B3RIX1_TRIAD	B3RJQ3_TRIAD	B3RIX1	B3RJQ3	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	FH2 domain-containing protein.	0.740
B3RIX1_TRIAD	B3RTX5_TRIAD	B3RIX1	B3RTX5	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	Uncharacterized protein.	0.488
B3RIX1_TRIAD	B3RW95_TRIAD	B3RIX1	B3RW95	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	Predicted protein.	0.760
B3RIX1_TRIAD	B3S0K8_TRIAD	B3RIX1	B3S0K8	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family.	0.624
B3RIX1_TRIAD	B3S128_TRIAD	B3RIX1	B3S128	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	Adenylyl cyclase-associated protein; Belongs to the CAP family.	0.724
B3RIX1_TRIAD	B3S5E4_TRIAD	B3RIX1	B3S5E4	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	Non-muscle actin 6.2.	0.485
B3RIX1_TRIAD	actin	B3RIX1	Q7YTV5	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	Actin.	0.485
B3RIX2_TRIAD	B3RJQ3_TRIAD	B3RIX2	B3RJQ3	Profilin; Belongs to the profilin family.	FH2 domain-containing protein.	0.740
B3RIX2_TRIAD	B3RTX5_TRIAD	B3RIX2	B3RTX5	Profilin; Belongs to the profilin family.	Uncharacterized protein.	0.488
B3RIX2_TRIAD	B3RW95_TRIAD	B3RIX2	B3RW95	Profilin; Belongs to the profilin family.	Predicted protein.	0.760
B3RIX2_TRIAD	B3S0K8_TRIAD	B3RIX2	B3S0K8	Profilin; Belongs to the profilin family.	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family.	0.624
B3RIX2_TRIAD	B3S128_TRIAD	B3RIX2	B3S128	Profilin; Belongs to the profilin family.	Adenylyl cyclase-associated protein; Belongs to the CAP family.	0.724
B3RIX2_TRIAD	B3S5E4_TRIAD	B3RIX2	B3S5E4	Profilin; Belongs to the profilin family.	Non-muscle actin 6.2.	0.485
B3RIX2_TRIAD	actin	B3RIX2	Q7YTV5	Profilin; Belongs to the profilin family.	Actin.	0.485
B3RJQ3_TRIAD	B3RIX1_TRIAD	B3RJQ3	B3RIX1	FH2 domain-containing protein.	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	0.740
B3RJQ3_TRIAD	B3RIX2_TRIAD	B3RJQ3	B3RIX2	FH2 domain-containing protein.	Profilin; Belongs to the profilin family.	0.740
B3RJQ3_TRIAD	B3RK40_TRIAD	B3RJQ3	B3RK40	FH2 domain-containing protein.	Uncharacterized protein.	0.498
B3RJQ3_TRIAD	B3RR54_TRIAD	B3RJQ3	B3RR54	FH2 domain-containing protein.	Uncharacterized protein.	0.511
B3RJQ3_TRIAD	B3RWD9_TRIAD	B3RJQ3	B3RWD9	FH2 domain-containing protein.	Profilin; Belongs to the profilin family.	0.829
B3RJQ3_TRIAD	B3S0K8_TRIAD	B3RJQ3	B3S0K8	FH2 domain-containing protein.	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family.	0.476