STRINGSTRING
KC8_05760 KC8_05760 pyrH pyrH pyrF pyrF dcd dcd KC8_07395 KC8_07395 surE surE KC8_08630 KC8_08630 KC8_08640 KC8_08640 pyrG pyrG pyrE pyrE KC8_17175 KC8_17175 KC8_20050 KC8_20050 surE-2 surE-2 cmk cmk ndk ndk KC8_04650 KC8_04650 KC8_16540 KC8_16540 thyA thyA KC8_02730 KC8_02730 KC8_02655 KC8_02655 pyrB pyrB KC8_01855 KC8_01855 carB carB carA carA tmk tmk KC8_13860 KC8_13860 pyrD pyrD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KC8_05760Unannotated protein. (303 aa)
pyrHUnannotated protein; Catalyzes the reversible phosphorylation of UMP to UDP. (240 aa)
pyrFUnannotated protein; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (224 aa)
dcdUnannotated protein; Catalyzes the deamination of dCTP to dUTP. (184 aa)
KC8_07395Unannotated protein. (154 aa)
surEUnannotated protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (256 aa)
KC8_08630Unannotated protein; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (350 aa)
KC8_08640Unannotated protein; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (651 aa)
pyrGUnannotated protein; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (544 aa)
pyrEUnannotated protein; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (194 aa)
KC8_17175Unannotated protein. (333 aa)
KC8_20050Unannotated protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (162 aa)
surE-2Unannotated protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (284 aa)
cmkUnannotated protein. (213 aa)
ndkUnannotated protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa)
KC8_04650Unannotated protein. (392 aa)
KC8_16540Unannotated protein. (441 aa)
thyAUnannotated protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
KC8_02730Unannotated protein. (196 aa)
KC8_02655Unannotated protein. (258 aa)
pyrBUnannotated protein; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (320 aa)
KC8_01855Unannotated protein. (408 aa)
carBUnannotated protein; Belongs to the CarB family. (1110 aa)
carAUnannotated protein; Belongs to the CarA family. (389 aa)
tmkUnannotated protein; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (208 aa)
KC8_13860Unannotated protein. (522 aa)
pyrDUnannotated protein; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (344 aa)
Your Current Organism:
Sphingomonas sp. KC8
NCBI taxonomy Id: 1030157
Other names: S. sp. KC8
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