STRINGSTRING
KC8_07095 KC8_07095 KC8_07090 KC8_07090 KC8_07600 KC8_07600 KC8_04270 KC8_04270 KC8_04265 KC8_04265 pgk pgk KC8_04245 KC8_04245 KC8_15430 KC8_15430 KC8_08570 KC8_08570 KC8_08650 KC8_08650 KC8_08660 KC8_08660 pdhA pdhA eno eno KC8_08765 KC8_08765 KC8_13155 KC8_13155 mdh mdh sucD sucD KC8_18000 KC8_18000 KC8_18005 KC8_18005 KC8_18010 KC8_18010 KC8_18205 KC8_18205 KC8_18540 KC8_18540 KC8_18695 KC8_18695 KC8_18700 KC8_18700 tal tal KC8_15170 KC8_15170 KC8_01910 KC8_01910 KC8_05660 KC8_05660 KC8_11050 KC8_11050 KC8_11110 KC8_11110 KC8_11450 KC8_11450 KC8_11625 KC8_11625 zwf zwf pgl pgl edd edd KC8_11870 KC8_11870 KC8_19610 KC8_19610 KC8_19530 KC8_19530 KC8_19895 KC8_19895 KC8_19860 KC8_19860 KC8_19855 KC8_19855 glyA glyA KC8_17270 KC8_17270 KC8_15365 KC8_15365 folD folD KC8_09190 KC8_09190 KC8_00300 KC8_00300 tpiA tpiA acsA acsA KC8_00680 KC8_00680 KC8_00755 KC8_00755 KC8_00885 KC8_00885 KC8_01010 KC8_01010 KC8_01045 KC8_01045 accD accD KC8_03175 KC8_03175 KC8_06410 KC8_06410 KC8_06365 KC8_06365 KC8_06310 KC8_06310 KC8_06305 KC8_06305 KC8_06245 KC8_06245 KC8_19695 KC8_19695 pckA pckA KC8_04800 KC8_04800 KC8_04720 KC8_04720 KC8_04715 KC8_04715 KC8_04710 KC8_04710 KC8_04705 KC8_04705 KC8_04605 KC8_04605 KC8_04535 KC8_04535 KC8_04530 KC8_04530 accA accA KC8_14085 KC8_14085 KC8_14100 KC8_14100 KC8_14110 KC8_14110 KC8_14115 KC8_14115 fumC fumC sucC sucC gpmA gpmA prs prs KC8_14555 KC8_14555 KC8_14685 KC8_14685 glk glk KC8_14780 KC8_14780 ppc ppc KC8_16440 KC8_16440 glcB glcB KC8_02815 KC8_02815 gcvH gcvH gcvPA gcvPA KC8_02795 KC8_02795 pgi pgi KC8_02565 KC8_02565 KC8_02560 KC8_02560 KC8_02555 KC8_02555 KC8_02550 KC8_02550 KC8_02205 KC8_02205 KC8_05245 KC8_05245 KC8_05295 KC8_05295 KC8_05365 KC8_05365 KC8_01440 KC8_01440 KC8_01420 KC8_01420 KC8_13875 KC8_13875 KC8_13855 KC8_13855 KC8_12880 KC8_12880 KC8_12860 KC8_12860
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KC8_07095Unannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (451 aa)
KC8_07090Unannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (159 aa)
KC8_07600Unannotated protein. (149 aa)
KC8_04270Unannotated protein; Belongs to the transketolase family. (656 aa)
KC8_04265Unannotated protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
pgkUnannotated protein; Belongs to the phosphoglycerate kinase family. (393 aa)
KC8_04245Unannotated protein. (304 aa)
KC8_15430Unannotated protein. (464 aa)
KC8_08570Unannotated protein. (240 aa)
KC8_08650Unannotated protein; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (550 aa)
KC8_08660Unannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (452 aa)
pdhAUnannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (353 aa)
enoUnannotated protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (425 aa)
KC8_08765Unannotated protein. (290 aa)
KC8_13155Unannotated protein. (328 aa)
mdhUnannotated protein; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (321 aa)
sucDUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
KC8_18000Unannotated protein. (966 aa)
KC8_18005Unannotated protein; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (418 aa)
KC8_18010Unannotated protein. (464 aa)
KC8_18205Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
KC8_18540Unannotated protein; Belongs to the methylenetetrahydrofolate reductase family. (313 aa)
KC8_18695Unannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (535 aa)
KC8_18700Unannotated protein. (384 aa)
talUnannotated protein; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa)
KC8_15170Unannotated protein; Belongs to the pyruvate kinase family. (491 aa)
KC8_01910Unannotated protein. (491 aa)
KC8_05660Unannotated protein. (531 aa)
KC8_11050Unannotated protein; Belongs to the PEP-utilizing enzyme family. (887 aa)
KC8_11110Unannotated protein; Belongs to the ribulose-phosphate 3-epimerase family. (234 aa)
KC8_11450Unannotated protein. (498 aa)
KC8_11625Unannotated protein. (289 aa)
zwfUnannotated protein; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (486 aa)
pglUnannotated protein; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (235 aa)
eddUnannotated protein; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (606 aa)
KC8_11870Unannotated protein. (203 aa)
KC8_19610Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
KC8_19530Unannotated protein. (316 aa)
KC8_19895Unannotated protein; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (406 aa)
KC8_19860Unannotated protein; Serine hydrolase involved in the detoxification of formaldehyde. (281 aa)
KC8_19855Unannotated protein; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (369 aa)
glyAUnannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (437 aa)
KC8_17270Unannotated protein. (152 aa)
KC8_15365Unannotated protein. (320 aa)
folDUnannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (296 aa)
KC8_09190Unannotated protein. (344 aa)
KC8_00300Unannotated protein. (413 aa)
tpiAUnannotated protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (248 aa)
acsAUnannotated protein; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (646 aa)
KC8_00680Unannotated protein. (365 aa)
KC8_00755Unannotated protein. (254 aa)
KC8_00885Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa)
KC8_01010Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
KC8_01045Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (383 aa)
accDUnannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (282 aa)
KC8_03175Unannotated protein. (231 aa)
KC8_06410Unannotated protein. (328 aa)
KC8_06365Unannotated protein. (174 aa)
KC8_06310Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
KC8_06305Unannotated protein. (727 aa)
KC8_06245Unannotated protein. (341 aa)
KC8_19695Unannotated protein; Belongs to the CoA-transferase III family. (400 aa)
pckAUnannotated protein; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (532 aa)
KC8_04800Unannotated protein; Belongs to the citrate synthase family. (428 aa)
KC8_04720Unannotated protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (261 aa)
KC8_04715Unannotated protein; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (600 aa)
KC8_04710Unannotated protein. (129 aa)
KC8_04705Unannotated protein. (143 aa)
KC8_04605Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
KC8_04535Unannotated protein. (624 aa)
KC8_04530Unannotated protein. (344 aa)
accAUnannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (313 aa)
KC8_14085Unannotated protein. (660 aa)
KC8_14100Unannotated protein. (717 aa)
KC8_14110Unannotated protein. (151 aa)
KC8_14115Unannotated protein. (510 aa)
fumCUnannotated protein; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa)
sucCUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (399 aa)
gpmAUnannotated protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (228 aa)
prsUnannotated protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (311 aa)
KC8_14555Unannotated protein. (324 aa)
KC8_14685Unannotated protein. (499 aa)
glkUnannotated protein; Belongs to the bacterial glucokinase family. (327 aa)
KC8_14780Unannotated protein. (754 aa)
ppcUnannotated protein; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (896 aa)
KC8_16440Unannotated protein. (424 aa)
glcBUnannotated protein; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (698 aa)
KC8_02815Unannotated protein. (373 aa)
gcvHUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (123 aa)
gcvPAUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (442 aa)
KC8_02795Unannotated protein. (522 aa)
pgiUnannotated protein; Belongs to the GPI family. (500 aa)
KC8_02565Unannotated protein. (68 aa)
KC8_02560Unannotated protein. (953 aa)
KC8_02555Unannotated protein. (497 aa)
KC8_02550Unannotated protein. (161 aa)
KC8_02205Unannotated protein. (300 aa)
KC8_05245Unannotated protein. (175 aa)
KC8_05295Unannotated protein. (144 aa)
KC8_05365Unannotated protein. (381 aa)
KC8_01440Unannotated protein. (504 aa)
KC8_01420Unannotated protein; Belongs to the cysteine synthase/cystathionine beta- synthase family. (306 aa)
KC8_13875Unannotated protein; Belongs to the ribose-phosphate pyrophosphokinase family. (330 aa)
KC8_13855Unannotated protein. (346 aa)
KC8_12880Unannotated protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (892 aa)
KC8_12860Unannotated protein; Belongs to the enoyl-CoA hydratase/isomerase family. (679 aa)
Your Current Organism:
Sphingomonas sp. KC8
NCBI taxonomy Id: 1030157
Other names: S. sp. KC8
Server load: low (24%) [HD]