STRINGSTRING
lpxC lpxC CINS_0258 CINS_0258 kpsF kpsF CINS_0286 CINS_0286 CINS_0287 CINS_0287 CINS_0288 CINS_0288 fcl fcl gmhA gmhA CINS_0321 CINS_0321 kdsA kdsA psd psd gmhB gmhB waaD waaD waaE waaE kdsC kdsC lpxD lpxD lpxK lpxK kdsB kdsB kdtA kdtA waaF waaF CINS_1209 CINS_1209 CINS_1210 CINS_1210 waaM waaM waaC waaC wlaX wlaX gne gne pglK pglK pglH pglH pglJ pglJ pglB pglB pglA pglA pglC pglC pglD pglD pglE pglE pglF pglF prmA prmA ftsH2 ftsH2 CINS_1227 CINS_1227 pssA pssA CINS_1229 CINS_1229 lpxH lpxH lpxB lpxB tsaC tsaC mreC mreC mrdB mrdB lpxA lpxA fabZ fabZ queH queH bcp bcp CINS_1348 CINS_1348 ilvE ilvE CINS_1350 CINS_1350 CINS_1351 CINS_1351 CINS_1352 CINS_1352
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lpxCUDP-3-O-acyl-N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (294 aa)
CINS_0258Glycosyltransferase, family 2; Pfam match to PF00535.21 Glycos_transf_2. (527 aa)
kpsFD-arabinose 5-phosphate isomerase; Pfam matches to PF01380.17 SIS, and to PF00571.23 CBS, and to PF00571.23 CBS; Belongs to the SIS family. GutQ/KpsF subfamily. (318 aa)
CINS_0286Capsular polysaccharide biosynthesis protein, putative glycosyltransferase (DUF2972 domain); Pfam match to PF11186.3 DUF2972. (603 aa)
CINS_0287Glycosyltransferase, family 2; Pfam matches to PF00535.21 Glycos_transf_2, and to PF00754.20 F5_F8_type_C. (1237 aa)
CINS_0288dTDP-4-dehydrorhamnose 3,5-epimerase; Pfam match to PF00908.12 dTDP_sugar_isom. (180 aa)
fclGDP-L-fucose synthetase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (345 aa)
gmhAPhosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (197 aa)
CINS_0321Lysophospholipid acyltransferase family protein (DUF374 domain); Pfam match to PF04028.8 DUF374. (207 aa)
kdsA3-deoxy-D-manno-octulosonate 8-phosphate synthase; Pfam match to PF00793.15 DAHP_synth_1; Belongs to the KdsA family. (267 aa)
psdPhosphatidylserine decarboxylase, proenzyme; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (269 aa)
gmhBD,D-heptose 1,7-bisphosphate phosphatase; Pfam match to PF08645.6 PNK3P. (171 aa)
waaDADP-L-glycero-D-mannoheptose-6-epimerase; Pfam match to PF01370.16 Epimerase. (318 aa)
waaED,D-heptose 1-phosphate adenosyltransferase / 7-phosphate kinase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (457 aa)
kdsC3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family; Pfam match to PF08282.7 Hydrolase_3. (162 aa)
lpxDUDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (320 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (303 aa)
kdsB3-deoxy-D-manno-octulosonate cytidylyltransferase; Pfam match to PF02348.14 CTP_transf_3; Belongs to the KdsB family. (241 aa)
kdtA3-deoxy-D-manno-octulosonic-acid transferase (KDO transferase); Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (391 aa)
waaFHeptosyltransferase II; Pfam match to PF01075.12 Glyco_transf_9. (306 aa)
CINS_1209Glycosyltransferase, family 2; Pfam match to PF00535.21 Glycos_transf_2. (390 aa)
CINS_1210Putative two-domain glycosyltransferase; Pfam matches to PF00535.21 Glycos_transf_2, and to PF02709.9 Glyco_transf_7C, and to PF00535.21 Glycos_transf_2. (518 aa)
waaMLipid A biosynthesis lauroyl acyltransferase; Pfam match to PF03279.8 Lip_A_acyltrans. (288 aa)
waaCHeptosyltransferase I; Pfam match to PF01075.12 Glyco_transf_9. (340 aa)
wlaXPutative polysaccharide biosynthesis protein; Pfam match to PF10108.4 DNA_pol_B_exo2. (260 aa)
gneUDP-GlcNAc/Glc 4-epimerase; Pfam matches to PF01370.16 Epimerase, and to PF13950.1 Epimerase_Csub; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (328 aa)
pglKFlippase; Pfam matches to PF00005.22 ABC_tran, and to PF00664.18 ABC_membrane. (564 aa)
pglHPfam matches to PF00534.15 Glycos_transf_1, and to PF13439.1 Glyco_transf_4. (355 aa)
pglJPfam matches to PF00534.15 Glycos_transf_1, and to PF13439.1 Glyco_transf_4. (366 aa)
pglBUndecaprenyl-diphosphooligosaccharide--protein glycotransferase; Pfam match to PF02516.9 STT3. (711 aa)
pglAN, N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase; Pfam matches to PF00534.15 Glycos_transf_1, and to PF13477.1 Glyco_trans_4_2. (375 aa)
pglCN,N'-diacetylbacilliosaminyl-1-phosphate transferase; Pfam match to PF02397.11 Bac_transf. (200 aa)
pglDUDP-4-amino-4, 6-dideoxy-alpha-D-N-acetyl-D-glucosamine N-acetyltransferase; Pfam match to PF14602.1 Hexapep_2. (196 aa)
pglEUDP-4-amino-4, 6-dideoxy-alpha-D-N-acetyl-D-glucosamine transaminase; Pfam match to PF01041.12 DegT_DnrJ_EryC1; Belongs to the DegT/DnrJ/EryC1 family. (386 aa)
pglFUDP-N-acetylglucosamine C-6 dehydratase; Pfam matches to PF02719.10 Polysacc_synt_2, and to PF13727.1 CoA_binding_3. (587 aa)
prmA50S ribosomal protein L11 methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. (279 aa)
ftsH2Integral membrane ATP-dependent zinc metallopeptidase; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (639 aa)
CINS_1227Phosphatidylserine decarboxylase-related protein; Pfam match to PF02666.10 PS_Dcarbxylase. (205 aa)
pssAPhosphatidylserine synthase; Pfam match to PF01066.16 CDP-OH_P_transf; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (236 aa)
CINS_1229PepSY-associated TM helix domain membrane protein; Pfam match to PF13172.1 PepSY_TM_1. (184 aa)
lpxHUDP-2,3-diacylglucosamine hydrolase; Pfam match to PF12850.2 Metallophos_2. (242 aa)
lpxBLipid A disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (364 aa)
tsaCthreonylcarbamoyl-AMP synthase TsaC. (140 aa)
mreCRod shape-determining protein MreC; Pfam match to PF04085.9 MreC. (247 aa)
mrdBCell wall shape-determining protein; Pfam match to PF06723.8 MreB_Mbl. (345 aa)
lpxAUDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (263 aa)
fabZ3-hydroxyacyl-[acp] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (146 aa)
queHHypothetical protein (DUF208 domain); Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (357 aa)
bcpThiol peroxidase; Pfam match to PF00578.16 AhpC-TSA. (153 aa)
CINS_13484-oxalocrotonate tautomerase family enzyme; Pfam match to PF01361.16 Tautomerase; Belongs to the 4-oxalocrotonate tautomerase family. (68 aa)
ilvEBranched-chain amino-acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (312 aa)
CINS_1350Prohibitin family protein, SPFH superfamily; Pfam match to PF01145.20 Band_7. (356 aa)
CINS_1351Hypothetical protein (DUF2393 domain); Pfam match to PF09624.5 DUF2393. (178 aa)
CINS_1352Hypothetical protein (DUF2393 domain); Pfam match to PF09624.5 DUF2393. (176 aa)
Your Current Organism:
Campylobacter insulaenigrae
NCBI taxonomy Id: 1031564
Other names: C. insulaenigrae NCTC 12927, Campylobacter insulaenigrae DSM 17739, Campylobacter insulaenigrae LMG 22716, Campylobacter insulaenigrae NCTC 12927, Campylobacter insulaenigrae str. NCTC 12927, Campylobacter insulaenigrae strain NCTC 12927
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.