STRINGSTRING
HTIA_1108 HTIA_1108 rps27e rps27e rpl44e rpl44e pyrI pyrI ferB ferB tfb-3 tfb-3 metG metG rpl37ae rpl37ae ligA ligA rpoN rpoN dtdA dtdA thiC thiC nfo nfo HTIA_2097 HTIA_2097 tgtA tgtA rnz rnz adh adh spt4 spt4 rps14 rps14 adk adk ileS ileS tfb-2 tfb-2 HTIA_1715 HTIA_1715 rps27ae rps27ae gutB gutB ribA ribA rnj rnj lysK lysK HTIA_1533 HTIA_1533 mtaD mtaD HTIA_1464 HTIA_1464 HTIA_1369 HTIA_1369 HTIA_1361 HTIA_1361 hisI hisI hem2 hem2 caaX caaX tfbG tfbG htpX htpX pyrC pyrC rpe rpe rpl24e rpl24e rpl37e rpl37e rad50 rad50 amzA amzA dnaJ dnaJ rpoM rpoM egsA egsA thrS thrS hisD hisD cxp cxp tfbB tfbB rnp4 rnp4 metE-2 metE-2 cysS cysS
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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HTIA_1108Transcription factor TFIIB cyclin-related protein. (325 aa)
rps27e30S ribosomal protein S27e. (57 aa)
rpl44e50S ribosomal protein L44e; Binds to the 23S rRNA. (61 aa)
pyrIAspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (152 aa)
ferBFerredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (108 aa)
tfb-3Transcription initiation factor B; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (328 aa)
metGmethionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (706 aa)
rpl37ae50S ribosomal protein L37Ae; Binds to the 23S rRNA. (94 aa)
ligANAD-dependent DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (693 aa)
rpoNDNA-directed RNA polymerase subunit N; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family. (52 aa)
dtdAD-aminoacyl-tRNA deacylase; D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo. (450 aa)
thiCThiamin biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (481 aa)
nfoEndodeoxyribonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (276 aa)
HTIA_2097Transcription factor S-related protein 1; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (98 aa)
tgtAArchaeosine tRNA-ribosyltransferase type 1; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. (489 aa)
rnzRibonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (331 aa)
adhThreonine dehydrogenase and related Zn-dependent dehydrogenases. (349 aa)
spt4DNA-directed RNA polymerase subunit E; Stimulates transcription elongation; Belongs to the archaeal Spt4 family. (65 aa)
rps1430S ribosomal protein S29e (S14p); Binds 16S rRNA, required for the assembly of 30S particles. (64 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa)
ileSisoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1068 aa)
tfb-2Transcription factor TFIIB cyclin-related protein; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (334 aa)
HTIA_1715Peptidase M48 Ste24p. (376 aa)
rps27ae30S ribosomal protein S27Ae; Belongs to the eukaryotic ribosomal protein eS31 family. (44 aa)
gutBAlcohol dehydrogenase GroES domain protein. (344 aa)
ribAGTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. (412 aa)
rnjBeta-lactamase domain protein; An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily. (447 aa)
lysKAcetylornithine deacetylase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine. (359 aa)
HTIA_1533Peptidase M50; Belongs to the peptidase M50B family. (414 aa)
mtaDAmidohydrolase; Catalyzes the deamination of 5-methylthioadenosine and S- adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine. Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family. (429 aa)
HTIA_1464Peptidase M48 Ste24p. (268 aa)
HTIA_1369Conserved hypothetical protein. (660 aa)
HTIA_1361Zinc finger SWIM domain-containing protein. (266 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (138 aa)
hem2Porphobilinogen synthase; Belongs to the ALAD family. (326 aa)
caaXSte24 endopeptidase. (421 aa)
tfbGTranscription factor TFIIB cyclin-related protein; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (321 aa)
htpXhtpX-like heat shock protease (peptidase M48); Belongs to the peptidase M48B family. (280 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (462 aa)
rpeRibulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (223 aa)
rpl24e30S ribosomal protein L24e; Binds to the 23S rRNA. (149 aa)
rpl37e50S ribosomal protein L37e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (57 aa)
rad50DNA double-strand break repair Rad50 ATPase. (890 aa)
amzAArchaemetzincin-family (M54 family) Zn-dependent peptidease; Probable zinc metalloprotease whose natural substrate is unknown. (173 aa)
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (387 aa)
rpoMTranscription factor S; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (97 aa)
egsAGlycerol-1-phosphate dehydrogenase [NAD(P)]; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. Belongs to the glycerol-1-phosphate dehydrogenase family. (352 aa)
thrSthreonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (620 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (424 aa)
cxpThermostable carboxypeptidase 1; Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. (497 aa)
tfbBTranscription initiation factor B. (282 aa)
rnp4Ribonuclease P protein component 4; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (97 aa)
metE-25-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown. (350 aa)
cysScysteinyl-tRNA synthetase. (496 aa)
Your Current Organism:
Halorhabdus tiamatea
NCBI taxonomy Id: 1033806
Other names: H. tiamatea SARL4B, Halorhabdus tiamatea JCM 14471, Halorhabdus tiamatea SARL4B, Halorhabdus tiamatea str. SARL4B, Halorhabdus tiamatea strain SARL4B
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