STRINGSTRING
atoA atoA atoD atoD sdhC sdhC sdhA sdhA sdhB sdhB CCB68268.1 CCB68268.1 pgk pgk pgi pgi pykA pykA paaE2 paaE2 sucA sucA sucB sucB fumA fumA CCB68459.1 CCB68459.1 gcdH gcdH aceA aceA aceB aceB CCB68501.1 CCB68501.1 prsA1 prsA1 fbaA fbaA pdhB pdhB gapN gapN crt crt rpe rpe mutB mutB mutA mutA gapA2 gapA2 maeB maeB CCB69141.1 CCB69141.1 CCB69157.1 CCB69157.1 lpdA2 lpdA2 tpiA tpiA CCB69308.1 CCB69308.1 CCB69310.1 CCB69310.1 CCB69312.1 CCB69312.1 argK argK bfmBB bfmBB mvaC mvaC CCB69549.1 CCB69549.1 pckA pckA CCB69563.1 CCB69563.1 CCB69565.1 CCB69565.1 CCB69566.1 CCB69566.1 maoC maoC paaJ paaJ paaI paaI paaH paaH paaG paaG paaD paaD paaC paaC paaB paaB paaA paaA paaE paaE lpdA1 lpdA1 mqo mqo mvaB mvaB ppc ppc CCB69724.1 CCB69724.1 tal tal gapA3 gapA3 pfkA pfkA mdh mdh prsA2 prsA2 CCB69949.1 CCB69949.1 sucC sucC icmF icmF sucD sucD gapA1 gapA1 acnB acnB bfmBA bfmBA etfB etfB etfA etfA CCB70356.1 CCB70356.1 pdhC pdhC pdhA pdhA tktC tktC tktA tktA CCB70456.1 CCB70456.1 gltA gltA eno eno fbp fbp tas tas icd icd capK capK rpiB rpiB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
atoA3-oxoacid CoA-transferase subunit B family protein AtoA. (217 aa)
atoD3-oxoacid CoA-transferase subunit A family protein AtoD. (232 aa)
sdhCSuccinate dehydrogenase, cytochrome b subunit. (221 aa)
sdhASuccinate dehydrogenase, flavoprotein subunit. (666 aa)
sdhBSuccinate dehydrogenase, iron-sulfur protein. (248 aa)
CCB68268.1Protein of unknown function. Putative AMP-dependent synthetase and ligase. (543 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (395 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (547 aa)
pykAPyruvate kinase; Belongs to the pyruvate kinase family. (476 aa)
paaE2Probable phenylacetic acid degradation NADH oxidoreductase PaaE2. (349 aa)
sucAOxoglutarate dehydrogenase (succinyl-transferring). (926 aa)
sucBDihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (407 aa)
fumAFumarate hydratase class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (533 aa)
CCB68459.1Probable lyase. (133 aa)
gcdHGlutaryl-CoA dehydrogenase. (392 aa)
aceAIsocitrate lyase; Glyoxylate bypass; first step (by similarity). (426 aa)
aceBMalate synthase; Glyoxylate bypass; second step (by similarity); Belongs to the malate synthase family. (533 aa)
CCB68501.1Probable transcriptional regulator, MerR family. (493 aa)
prsA1Ribose-phosphate diphosphokinase. (313 aa)
fbaAFructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (355 aa)
pdhBPyruvate dehydrogenase E1 component, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (325 aa)
gapNNADP-dependent glyceraldehyde-3-phosphate dehydrogenase. (526 aa)
crtProbable 3-hydroxybutyryl-CoA dehydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (260 aa)
rpeRibulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (220 aa)
mutBMethylmalonyl-CoA mutase large subunit. (708 aa)
mutAMethylmalonyl-CoA mutase small subunit. (454 aa)
gapA2Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (482 aa)
maeBMalate dehydrogenase (oxaloacetate-decarboxylating) (NADP+). (768 aa)
CCB69141.1Carboxyltransferase. (542 aa)
CCB69157.1Aldehyde dehydrogenase. (450 aa)
lpdA2Dihydrolipoyl dehydrogenase. (462 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (250 aa)
CCB69308.1Acyl-CoA dehydrogenase family protein. (596 aa)
CCB69310.1Acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
CCB69312.13-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase/isomerase family protein. (796 aa)
argKTransport binding protein kinase ArgK. (361 aa)
bfmBBDihydrolipoyllysine-residue (2-methylpropanoyl) transferase. (440 aa)
mvaCAcetyl-CoA acetyltransferase; Metabolic intermediate biosynthesis; mevalonate biosynthesis; R-mevalonate from acetyl-CoA: step 1/3; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
CCB69549.1Putative pyruvate/branched-chain alpha-keto acid dehydrogenase (E1) component, alpha and beta subunits. (800 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (541 aa)
CCB69563.13-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring). (691 aa)
CCB69565.1Dihydrolipoyllysine-residue (2-methylpropanoyl) transferase. (441 aa)
CCB69566.1Enoyl-CoA hydratase/isomerase family protein. (252 aa)
maoCPhenylacetic acid degradation protein MaoC (PaaZ). (832 aa)
paaJBeta-ketoadipyl-CoA thiolase PaaJ; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
paaIAcyl-coenzyme A thioesterase PaaI. (142 aa)
paaHProbable 3-hydroxybutyryl-CoA dehydrogenase PaaH. (402 aa)
paaGProbable enoyl-CoA hydratase PaaG; Belongs to the enoyl-CoA hydratase/isomerase family. (257 aa)
paaDPhenylacetic acid degradation protein PaaD. (161 aa)
paaCPhenylacetic acid degradation protein PaaC. (250 aa)
paaBPhenylacetic acid degradation protein PaaB. (94 aa)
paaAPhenylacetic acid degradation protein PaaA. (314 aa)
paaEProbable phenylacetic acid degradation NADH oxidoreductase PaaE. (357 aa)
lpdA1Dihydrolipoyl dehydrogenase. (467 aa)
mqoMalate dehydrogenase (acceptor). (499 aa)
mvaBHydroxymethylglutaryl-CoA lyase. (288 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (861 aa)
CCB69724.1Protein of unknown function; N-terminal region similar to FAD/FMN-containing dehydrogenases COG0277 and C-terminal region similar to Fe-S oxidoreductase COG0247. (966 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (218 aa)
gapA3Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (328 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (311 aa)
prsA2Ribose-phosphate diphosphokinase; Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1; Belongs to the ribose-phosphate pyrophosphokinase family. (275 aa)
CCB69949.13-hydroxyacyl-CoA dehydrogenase family protein. (296 aa)
sucCSuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (397 aa)
icmFMethylmalonyl-CoA mutase; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1147 aa)
sucDSuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
gapA1Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
acnBAconitate hydratase; Carbohydrate metabolism; tricarboxylic acid cycle. (929 aa)
bfmBA3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring). (658 aa)
etfBElectron transfer flavoprotein, beta subunit. (248 aa)
etfAElectron transfer flavoprotein, alpha subunit. (321 aa)
CCB70356.1Acyl-CoA dehydrogenase family protein. (379 aa)
pdhCPyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). (528 aa)
pdhAPyruvate dehydrogenase E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (333 aa)
tktCTransketolase, C-terminal subunit. (317 aa)
tktATransketolase, N-terminal subunit. (281 aa)
CCB70456.1Phosphoglucomutase/phosphomannomutase family protein. (574 aa)
gltACitrate (Si)-synthase; Belongs to the citrate synthase family. (427 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa)
fbpFructose-bisphosphatase. (333 aa)
tasOxidoreductase Tas, aldo/keto reductase family. (345 aa)
icdIsocitrate dehydrogenase (NADP+); Belongs to the isocitrate and isopropylmalate dehydrogenases family. (407 aa)
capKPutative capsular polysaccharide biosynthesis protein CapK. (437 aa)
rpiBRibose 5-phosphate isomerase. (143 aa)
Your Current Organism:
Flavobacterium branchiophilum
NCBI taxonomy Id: 1034807
Other names: F. branchiophilum FL-15, Flavobacterium branchiophilum FL-15, Flavobacterium branchiophilum str. FL-15, Flavobacterium branchiophilum strain FL-15
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.