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| | CCB68330.1 | Cys/Met metabolism PLP-dependent enzyme. (380 aa) |
| | lysC | Aspartate kinase; Belongs to the aspartokinase family. (416 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (261 aa) |
| | ansA | Asparaginase 1. (342 aa) |
| | pruA | 1-pyrroline-5-carboxylate dehydrogenase. (542 aa) |
| | aspC1 | Probable aspartate transaminase AspC1. (396 aa) |
| | ilvA | Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (414 aa) |
| | ilvH | Acetolactate synthase, small subunit. (195 aa) |
| | ilvB | Acetolactate synthase, large subunit. (583 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (559 aa) |
| | CCB68992.1 | Probable asparagine synthetase [glutamine-hydrolyzing]. (536 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (354 aa) |
| | argD | Acetylornithine/succinyldiaminopimelatetransamin ase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (396 aa) |
| | CCB69033.1 | Glu/Leu/Phe/Val dehydrogenase family protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (408 aa) |
| | metZ | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (393 aa) |
| | thrA2 | Bifunctional enzyme : aspartate kinase/homoserine dehydrogenase. (812 aa) |
| | metX | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. (320 aa) |
| | metY | Probable O-acetylhomoserine aminocarboxypropyltransferase. (421 aa) |
| | asnB2 | Asparagine synthetase [glutamine-hydrolyzing] AsnB2. (616 aa) |
| | hisH2 | Imidazole glycerol phosphate synthase subunit HisH2; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (202 aa) |
| | hisF2 | Imidazole glycerol phosphate synthase subunit HisF2; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa) |
| | dapB | Dihydrodipicolinate reductase; Belongs to the DapB family. (233 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (137 aa) |
| | sdaA | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (475 aa) |
| | CCB69265.1 | Arginase family protein; Belongs to the arginase family. (372 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (329 aa) |
| | aspC4 | Probable aspartate transaminase AspC4. (386 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (494 aa) |
| | glnA | Glutamate--ammonia ligase; Annotation automatically inferred by bidirectionnal best hit with 341 from FP; Belongs to the glutamine synthetase family. (729 aa) |
| | asnB1 | Asparagine synthetase [glutamine-hydrolyzing] AsnB1. (631 aa) |
| | pabB | Para-aminobenzoate synthase component I. (440 aa) |
| | serA | Phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (316 aa) |
| | serC | Phosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa) |
| | rocD | Ornithine--oxo-acid transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (414 aa) |
| | CCB69564.1 | Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase family protein; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (350 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferas; Belongs to the transferase hexapeptide repeat family. (271 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (356 aa) |
| | hisIE | Histidine biosynthesis bifunctional protein HisIE [Includes: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphatase]; In the N-terminal section; belongs to the PRA-CH family. (199 aa) |
| | hisF1 | Imidazole glycerol phosphate synthase subunit HisF1; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (251 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino) methylideneamino)imidazole-4-carboxamide isomerase. (242 aa) |
| | hisH1 | Imidazole glycerol phosphate synthase subunit HisH1; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (194 aa) |
| | hisB | Histidine biosynthesis bifunctional protein HisB [Includes: Histidinol-phosphatase (EC 3.1.3.15); Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) (IGPD)]. (377 aa) |
| | hisC | Histidinol-phosphate transaminase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (349 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (430 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (285 aa) |
| | CCB69763.1 | Cysteine synthase/cystathionine beta-synthase family protein. (346 aa) |
| | CCB69770.1 | Probable M1 family metalloprotease. (687 aa) |
| | ggt2 | Gamma-glutamyltransferase. (565 aa) |
| | pepA | Leucyl aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity); Belongs to the peptidase M17 family. (481 aa) |
| | thrA1 | Bifunctional enzyme : aspartate kinase/homoserine dehydrogenase. (815 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (307 aa) |
| | thrC | Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5. (430 aa) |
| | putA | Proline dehydrogenase. (388 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa) |
| | trpE | Anthranilate synthase component I. (466 aa) |
| | pabA | Para-aminobenzoate/anthranilate synthase glutamine amidotransferase component II. (205 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (330 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (260 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (222 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (395 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (253 aa) |
| | aspC2 | Probable aspartate transaminase AspC2. (397 aa) |
| | gltD | Probable glutamate synthase (NADPH) small subunit; Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NADPH route): step 1/1. (484 aa) |
| | gltB | Probable glutamate synthase (NADPH) large subunit. (1501 aa) |
| | CCB70093.1 | Probable acetyltransferase, GNAT family. (205 aa) |
| | argG | Argininosuccinate synthase; Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. (395 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (325 aa) |
| | CCB70096.1 | Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (376 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (398 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (253 aa) |
| | argF | Ornithine carbamoyltransferase; Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (316 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (264 aa) |
| | argE | Acetylornithine deacetylase; Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine from N(2)-acetyl-L-ornithine (linear): step 1/1. (356 aa) |
| | argH | Argininosuccinate lyase; Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. (426 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (172 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (401 aa) |
| | CCB70291.1 | Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase family protein; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (354 aa) |
| | aroE | Shikimate dehydrogenase. (244 aa) |
| | CCB70360.1 | Cysteine synthase/cystathionine beta-synthase family protein. (453 aa) |
| | pepD | Xaa-His dipeptidase. (489 aa) |
| | CCB70488.1 | Putative ferredoxin-dependent glutamate synthase; Belongs to the glutamate synthase family. (501 aa) |
| | CCB70587.1 | Protein of unknown function. (514 aa) |
| | leuA | 2-isopropylmalate synthase; Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4; Belongs to the alpha-IPM synthase/homocitrate synthase family. (388 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (459 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (194 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (373 aa) |
| | CCB70605.1 | Methionine synthase, homocysteine S-methyltransferase domain. (325 aa) |
| | CCB70607.1 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1063 aa) |
| | metF | Methylenetetrahydrofolate reductase (NAD(P)H); Belongs to the methylenetetrahydrofolate reductase family. (318 aa) |
| | CCB70637.1 | Putative phospho-2-dehydro-3-deoxyheptonate aldolase. (360 aa) |
| | tyrA | Prephenate dehydrogenase; Amino-acid biosynthesis; L-tyrosine biosynthesis; L-tyrosine from prephenate: step 1/2. (282 aa) |
| | aspC3 | Probable aspartate transaminase AspC3. (381 aa) |
| | pheA | Prephenate dehydratase. (276 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (410 aa) |
| | gdhA | Glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (447 aa) |
| | CCB70764.1 | Putative phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (318 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (258 aa) |
| | ahcY | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (439 aa) |
