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sdhC sdhC sdhA sdhA sdhB sdhB pgk pgk pgi pgi pykA pykA accB accB accC accC sucA sucA sucB sucB fumA fumA CCB68459.1 CCB68459.1 gpmI gpmI aceA aceA aceB aceB prsA1 prsA1 fbaA fbaA accD accD pdhB pdhB gapN gapN crt crt rpe rpe mutB mutB mutA mutA gapA2 gapA2 CCB68928.1 CCB68928.1 ilvA ilvA maeB maeB gcvH gcvH lpdA2 lpdA2 sdaA sdaA tpiA tpiA CCB69312.1 CCB69312.1 bfmBB bfmBB mvaC mvaC accA accA gcvP gcvP pgl pgl serA serA serC serC pckA pckA CCB69565.1 CCB69565.1 paaH paaH lpdA1 lpdA1 mqo mqo ppc ppc tal tal gapA3 gapA3 pfkA pfkA gcvT gcvT acsA acsA mdh mdh prsA2 prsA2 fabV fabV CCB69949.1 CCB69949.1 sucC sucC glyA glyA sucD sucD gapA1 gapA1 acnB acnB folD folD pdhC pdhC pdhA pdhA tktC tktC tktA tktA gltA gltA eno eno metF metF CCB70664.1 CCB70664.1 kdgK kdgK fbp fbp CCB70764.1 CCB70764.1 icd icd rpiB rpiB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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sdhCSuccinate dehydrogenase, cytochrome b subunit. (221 aa)
sdhASuccinate dehydrogenase, flavoprotein subunit. (666 aa)
sdhBSuccinate dehydrogenase, iron-sulfur protein. (248 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (395 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (547 aa)
pykAPyruvate kinase; Belongs to the pyruvate kinase family. (476 aa)
accBAcetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (161 aa)
accCBiotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa)
sucAOxoglutarate dehydrogenase (succinyl-transferring). (926 aa)
sucBDihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (407 aa)
fumAFumarate hydratase class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (533 aa)
CCB68459.1Probable lyase. (133 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (505 aa)
aceAIsocitrate lyase; Glyoxylate bypass; first step (by similarity). (426 aa)
aceBMalate synthase; Glyoxylate bypass; second step (by similarity); Belongs to the malate synthase family. (533 aa)
prsA1Ribose-phosphate diphosphokinase. (313 aa)
fbaAFructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (355 aa)
accDAcetyl-coenzyme A carboxylase carboxyl transferase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (284 aa)
pdhBPyruvate dehydrogenase E1 component, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (325 aa)
gapNNADP-dependent glyceraldehyde-3-phosphate dehydrogenase. (526 aa)
crtProbable 3-hydroxybutyryl-CoA dehydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (260 aa)
rpeRibulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (220 aa)
mutBMethylmalonyl-CoA mutase large subunit. (708 aa)
mutAMethylmalonyl-CoA mutase small subunit. (454 aa)
gapA2Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (482 aa)
CCB68928.1Propionyl-CoA carboxylase, beta subunit. (513 aa)
ilvAThreonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (414 aa)
maeBMalate dehydrogenase (oxaloacetate-decarboxylating) (NADP+). (768 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
lpdA2Dihydrolipoyl dehydrogenase. (462 aa)
sdaAL-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (475 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (250 aa)
CCB69312.13-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase/isomerase family protein. (796 aa)
bfmBBDihydrolipoyllysine-residue (2-methylpropanoyl) transferase. (440 aa)
mvaCAcetyl-CoA acetyltransferase; Metabolic intermediate biosynthesis; mevalonate biosynthesis; R-mevalonate from acetyl-CoA: step 1/3; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
accAAcetyl-coenzyme A carboxylase carboxyl transferase alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa)
gcvPGlycine dehydrogenase (decarboxylating); Belongs to the GcvP family. (947 aa)
pglProbable 6-phosphogluconolactonase precursor. (368 aa)
serAPhosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (316 aa)
serCPhosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (541 aa)
CCB69565.1Dihydrolipoyllysine-residue (2-methylpropanoyl) transferase. (441 aa)
paaHProbable 3-hydroxybutyryl-CoA dehydrogenase PaaH. (402 aa)
lpdA1Dihydrolipoyl dehydrogenase. (467 aa)
mqoMalate dehydrogenase (acceptor). (499 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (861 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (218 aa)
gapA3Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (328 aa)
gcvTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (364 aa)
acsAAcetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (635 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (311 aa)
prsA2Ribose-phosphate diphosphokinase; Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1; Belongs to the ribose-phosphate pyrophosphokinase family. (275 aa)
fabVProtein of unknown function. Putative trans-2-enoyl-CoA reductase; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (398 aa)
CCB69949.13-hydroxyacyl-CoA dehydrogenase family protein. (296 aa)
sucCSuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (397 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (424 aa)
sucDSuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
gapA1Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
acnBAconitate hydratase; Carbohydrate metabolism; tricarboxylic acid cycle. (929 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (295 aa)
pdhCPyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). (528 aa)
pdhAPyruvate dehydrogenase E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (333 aa)
tktCTransketolase, C-terminal subunit. (317 aa)
tktATransketolase, N-terminal subunit. (281 aa)
gltACitrate (Si)-synthase; Belongs to the citrate synthase family. (427 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa)
metFMethylenetetrahydrofolate reductase (NAD(P)H); Belongs to the methylenetetrahydrofolate reductase family. (318 aa)
CCB70664.1KHG/KDPG aldolase. (222 aa)
kdgKPutative 2-dehydro-3-deoxygluconokinase. (340 aa)
fbpFructose-bisphosphatase. (333 aa)
CCB70764.1Putative phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (318 aa)
icdIsocitrate dehydrogenase (NADP+); Belongs to the isocitrate and isopropylmalate dehydrogenases family. (407 aa)
rpiBRibose 5-phosphate isomerase. (143 aa)
Your Current Organism:
Flavobacterium branchiophilum
NCBI taxonomy Id: 1034807
Other names: F. branchiophilum FL-15, Flavobacterium branchiophilum FL-15, Flavobacterium branchiophilum str. FL-15, Flavobacterium branchiophilum strain FL-15
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