(42 nodes) Homologous recombination network (Aspergillus versicolor)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1L9P343	Uncharacterized protein. (785 aa)
	A0A1L9P385	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2854 aa)
	A0A1L9P3A5	Uncharacterized protein. (124 aa)
	A0A1L9P456	HD domain-containing protein. (235 aa)
	A0A1L9P543	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (791 aa)
	A0A1L9P572	RPA_C domain-containing protein. (273 aa)
	A0A1L9P5I6	Smr domain-containing protein. (236 aa)
	A0A1L9P6U5	Uncharacterized protein. (735 aa)
	A0A1L9P7M7	Uncharacterized protein. (85 aa)
	A0A1L9P829	PITH domain-containing protein. (225 aa)
	A0A1L9PA12	HD domain-containing protein. (253 aa)
	A0A1L9PAY2	Uncharacterized protein. (1546 aa)
	A0A1L9PB14	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (213 aa)
	A0A1L9PB25	Uncharacterized protein. (185 aa)
	A0A1L9PC51	Uncharacterized protein. (1690 aa)
	A0A1L9PCW2	DNA polymerase. (1110 aa)
	A0A1L9PCY5	Uncharacterized protein. (454 aa)
	A0A1L9PDD5	Uncharacterized protein. (470 aa)
	A0A1L9PE93	Uncharacterized protein. (426 aa)
	A0A1L9PEH5	Uncharacterized protein. (194 aa)
	A0A1L9PEJ9	ERCC4 domain-containing protein. (596 aa)
	A0A1L9PET4	Uncharacterized protein. (533 aa)
	A0A1L9PHA7	FHA domain-containing protein. (696 aa)
	A0A1L9PIJ5	Uncharacterized protein. (385 aa)
	A0A1L9PJ65	C-type lectin domain-containing protein. (596 aa)
	A0A1L9PJD7	Stn1 domain-containing protein. (290 aa)
	A0A1L9PL02	Uncharacterized protein. (183 aa)
	A0A1L9PLH2	Uncharacterized protein. (538 aa)
	A0A1L9PMA5	Uncharacterized protein. (1672 aa)
	A0A1L9PPV8	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (629 aa)
	A0A1L9PQ69	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (557 aa)
	A0A1L9PQI6	Uncharacterized protein. (595 aa)
	A0A1L9PR00	Uncharacterized protein. (435 aa)
	A0A1L9PRB5	Uncharacterized protein. (718 aa)
	A0A1L9PRD1	Uncharacterized protein. (370 aa)
	A0A1L9PRE2	Uncharacterized protein. (141 aa)
	A0A1L9PSU1	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (603 aa)
	A0A1L9PU32	Uncharacterized protein. (335 aa)
	A0A1L9PVG7	Zds_C domain-containing protein. (850 aa)
	A0A1L9PVL6	Uncharacterized protein. (517 aa)
	A0A1L9PX20	Uncharacterized protein. (272 aa)
	A0A1L9Q027	Uncharacterized protein. (220 aa)

Your Current Organism:

Aspergillus versicolor

NCBI taxonomy Id: 1036611
Other names: A. versicolor CBS 583.65, Aspergillus versicolor CBS 583.65

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1L9P343	A0A1L9P385	Uncharacterized protein.	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	0.891
A0A1L9P343	A0A1L9P543	Uncharacterized protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.783
A0A1L9P343	A0A1L9P572	Uncharacterized protein.	RPA_C domain-containing protein.	0.749
A0A1L9P343	A0A1L9PAY2	Uncharacterized protein.	Uncharacterized protein.	0.905
A0A1L9P343	A0A1L9PCW2	Uncharacterized protein.	DNA polymerase.	0.705
A0A1L9P343	A0A1L9PDD5	Uncharacterized protein.	Uncharacterized protein.	0.785
A0A1L9P343	A0A1L9PEJ9	Uncharacterized protein.	ERCC4 domain-containing protein.	0.547
A0A1L9P343	A0A1L9PJD7	Uncharacterized protein.	Stn1 domain-containing protein.	0.706
A0A1L9P343	A0A1L9PMA5	Uncharacterized protein.	Uncharacterized protein.	0.512
A0A1L9P343	A0A1L9PPV8	Uncharacterized protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.746
A0A1L9P343	A0A1L9PQ69	Uncharacterized protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.734
A0A1L9P343	A0A1L9PQI6	Uncharacterized protein.	Uncharacterized protein.	0.786
A0A1L9P343	A0A1L9PR00	Uncharacterized protein.	Uncharacterized protein.	0.785
A0A1L9P343	A0A1L9PRD1	Uncharacterized protein.	Uncharacterized protein.	0.702
A0A1L9P343	A0A1L9PSU1	Uncharacterized protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.871
A0A1L9P343	A0A1L9PU32	Uncharacterized protein.	Uncharacterized protein.	0.785
A0A1L9P343	A0A1L9Q027	Uncharacterized protein.	Uncharacterized protein.	0.596
A0A1L9P385	A0A1L9P343	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	Uncharacterized protein.	0.891
A0A1L9P385	A0A1L9P456	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	HD domain-containing protein.	0.444
A0A1L9P385	A0A1L9P543	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.986