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alr0051 alr0051 alr0068 alr0068 alr0094 alr0094 alr0106 alr0106 alr0212 alr0212 alr0512 alr0512 alr0515 alr0515 all0788 all0788 purK purK alr1155 alr1155 alr1299 alr1299 alr1623 alr1623 all1681 all1681 alr1912 alr1912 all2063 all2063 alr2083 alr2083 purC purC all2303 all2303 asr2474 asr2474 alr2475 alr2475 alr2742 alr2742 all2846 all2846 alr2945 alr2945 alr2983 alr2983 purH purH alr3139 alr3139 alr3202 alr3202 all3284 all3284 alr3285 alr3285 alr3339 alr3339 alr3395 alr3395 alr3510 alr3510 alr3525 alr3525 all3651 all3651 all3652 all3652 alr3809 alr3809 all4035 all4035 all4196 all4196 all4272 all4272 all4418 all4418 alr4582 alr4582 all4708 all4708 alr4784 alr4784 all4825 all4825 alr4846 alr4846 all5088 all5088 alr5099 alr5099
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
alr0051IMP dehydrogenase; ORF_ID:alr0051. (387 aa)
alr0068Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (184 aa)
alr0094Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (292 aa)
alr0106Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (199 aa)
alr0212Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (299 aa)
alr0512ORF_ID:alr0512; hypothetical protein. (268 aa)
alr0515Alr0515 protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (240 aa)
all0788Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (240 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (175 aa)
alr1155Carbamoyl phosphate synthase small subunit; ORF_ID:alr1155; Belongs to the CarA family. (388 aa)
alr1299Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (391 aa)
alr1623Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (284 aa)
all1681Aspartate carbamoyltransferase; ORF_ID:all1681; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (333 aa)
alr1912Alr1912 protein; Catalyzes the conversion of dihydroorotate to orotate. (343 aa)
all2063Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (216 aa)
alr2083Uracil phosphoribosyltransferase; Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines. (180 aa)
purCPhosphoribosylaminoimidazolesuccinocarboxamide synthase; ORF_ID:alr2268; purC gene product; Belongs to the SAICAR synthetase family. (245 aa)
all2303Dihydroorotase; ORF_ID:all2303. (439 aa)
asr2474Phosphoribosylformylglycinamidine synthase subunit PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (92 aa)
alr2475Phosphoribosylformyl glycinamidine synthetase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (224 aa)
alr2742Phosphoribosyl aminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (380 aa)
all2846GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (540 aa)
alr2945Orotidine 5'-phosphate decarboxylase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP); In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (500 aa)
alr2983Orotidine 5' monophosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (238 aa)
purHBifunctional purine biosynthesis protein; ORF_ID:all3093; purH gene product. (506 aa)
alr3139Putative 5'-nucleotidase alr3139; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (226 aa)
alr3202Inosine-uridine preferring nucleoside hydrolase; ORF_ID:alr3202. (289 aa)
all3284Cytosine deaminase; ORF_ID:all3284. (143 aa)
alr3285Inosine-adenosine-guanosine-nucleoside hydrolase; ORF_ID:alr3285. (307 aa)
alr3339Dihydroorotase; ORF_ID:alr3339. (435 aa)
alr3395Adenylosuccinate lyase; ORF_ID:alr3395; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (431 aa)
alr3510Phosphoribosylamine--glycine ligase; ORF_ID:alr3510. (425 aa)
alr3525Phosphoribosylformylglycinamidine cyclo-ligase; ORF_ID:alr3525. (425 aa)
all3651Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (499 aa)
all3652Phosphoribosylformyl glycinamidine synthetase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (782 aa)
alr3809Carbamoyl phosphate synthetase large chain; ORF_ID:alr3809. (1104 aa)
all4035ORF_ID:all4035; unknown protein. (1172 aa)
all4196Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (184 aa)
all4272Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (376 aa)
all4418ORF_ID:all4418; unknown protein. (347 aa)
alr4582Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (172 aa)
all4708Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (211 aa)
alr4784Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (419 aa)
all48255-formyltetrahydrofolate cyclo-ligase; ORF_ID:all4825; hypothetical protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (193 aa)
alr4846Stationary phase survival protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (265 aa)
all5088dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (196 aa)
alr5099Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (206 aa)
Your Current Organism:
Nostoc sp. PCC7120
NCBI taxonomy Id: 103690
Other names: Anabaena sp. (ATCC 27893), Anabaena sp. (PCC 7120), Anabaena sp. DCC D0672, Anabaena sp. PCC 7120, Anabaena sp. SAG 25.82, Anabaena sp. UTEX B 2576, Anabaena variabilis UTCC 387, N. sp. PCC 7120, Nostoc muscorum ISU, Nostoc sp. AKM24, Nostoc sp. ATCC 27347, Nostoc sp. ATCC 72893, Nostoc sp. DSM 107007, Nostoc sp. Ind43, Nostoc sp. PCC 7120, Nostoc sp. SAG 25.82
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