STRINGSTRING
alr2321 alr2321 alr2271 alr2271 aroK aroK alr1921 alr1921 alr1913 alr1913 alr1910 alr1910 fabG-2 fabG-2 all1863 all1863 icd icd all1694 all1694 asl1650 asl1650 all1649 all1649 all1648 all1648 hglE hglE all1644 all1644 all1643 all1643 desA desA all1522 all1522 all1319 all1319 alr1282 alr1282 all1228 all1228 gap3 gap3 alr1050 alr1050 all0985 all0985 accC accC all0938 all0938 all0769 all0769 alr0725 alr0725 glcE glcE all0580 all0580 all0412 all0412 all0396 all0396 bioF bioF all0324 all0324 all0292 all0292 alr0240 alr0240 alr0239 alr0239 plsX plsX all0122 all0122 menE menE all0635 all0635 hglC hglC hglD hglD alr5353 alr5353 accA accA alr5275 alr5275 glcD glcD all5167 all5167 accB accB alr4803 alr4803 all4667 all4667 fda fda all4520 all4520 alr4455 alr4455 all4443 all4443 all4427 all4427 all4391 all4391 alr4385 alr4385 alr4351 alr4351 all4286 all4286 all4257 all4257 all4256 all4256 all4182 all4182 all4131 all4131 alr4059 alr4059 all4008 all4008 alr3926 alr3926 alr3883 alr3883 all3735 all3735 alr3606 alr3606 alr3602 alr3602 all3569 all3569 all3556 all3556 all3538 all3538 alr3419 alr3419 alr3397 alr3397 alr3343 alr3343 asr3342 asr3342 all3341 all3341 alr3230 alr3230 alr3147 alr3147 alr3146 alr3146 all3111 all3111 alr2973 alr2973 alr2948 alr2948 panC panC alr2708 alr2708 alr2680 alr2680 alr2679 alr2679 all2646 all2646 all2635 all2635 gap1 gap1 all2564 all2564 all2509 all2509 all2501 all2501 alr2398 alr2398 accD accD alr2331 alr2331
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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alr2321Lactoylglutathione lyase; ORF_ID:alr2321. (145 aa)
alr2271(3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (171 aa)
aroKShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (289 aa)
alr1921Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (335 aa)
alr19136-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (357 aa)
alr1910ORF_ID:alr1910; unknown protein. (296 aa)
fabG-23-oxoacyl-[acyl-carrier protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (251 aa)
all1863Carboxyphosphonoenolpyruvate phosphonomutase; ORF_ID:all1863. (287 aa)
icdIsocitrate dehydrogenase; ORF_ID:alr1827; icd gene product. (473 aa)
all1694Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (291 aa)
asl1650ORF_ID:asl1650; similar to polyketide synthase. (85 aa)
all1649ORF_ID:all1649; similar to polyketide synthase. (1570 aa)
all1648ORF_ID:all1648; similar to polyketide synthase. (1587 aa)
hglEHeterocyst glycolipid synthase; ORF_ID:all1646; hglE gene product. (1263 aa)
all1644ORF_ID:all1644; hypothetical protein. (585 aa)
all1643ORF_ID:all1643; hypothetical protein. (1601 aa)
desAPhosphatidylcholine desaturase; ORF_ID:all1598; desA gene product. (350 aa)
all15223-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (257 aa)
all13192-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (319 aa)
alr1282Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (300 aa)
all1228ORF_ID:all1228; hypothetical protein. (298 aa)
gap3Glyceraldehyde-3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-phosphate dehydrogenase [...] (337 aa)
alr1050Glucose-6-phosphate isomerase; ORF_ID:alr1050. (528 aa)
all09854-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (402 aa)
accCBiotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa)
all0938ORF_ID:all0938; hypothetical protein. (137 aa)
all0769acetyl-CoA synthetase; ORF_ID:all0769. (916 aa)
alr0725ORF_ID:alr0725; hypothetical protein. (148 aa)
glcEGlycolate oxidase subunit; ORF_ID:all0624; glcE gene product. (431 aa)
all0580Hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. (257 aa)
all0412ORF_ID:all0412; putative zinc-binding oxidoreductase. (318 aa)
all0396Diaminobutyrate--pyruvate transaminase; ORF_ID:all0396; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (493 aa)
bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (386 aa)
all0324ORF_ID:all0324; hypothetical protein. (447 aa)
all0292ORF_ID:all0292; hypothetical protein. (199 aa)
alr0240Malonyl coenzyme A-acyl carrier protein transacylase; ORF_ID:alr0240. (292 aa)
alr0239Beta-ketoacyl-acyl carrier protein synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (330 aa)
plsXFatty acid/phospholipid synthesis protein; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (341 aa)
all0122Pyruvate dehydrogenase E1 beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (327 aa)
menEO-succinylbenzoyl-CoA synthetase; ORF_ID:alr0035; menE gene product. (483 aa)
all0635Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (821 aa)
hglCHeterocyst glycolipid synthase; ORF_ID:alr5355; hglC gene product; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (1109 aa)
hglDHeterocyst glycolipid synthase; ORF_ID:alr5354; hglD gene product; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (453 aa)
alr5353ORF_ID:alr5353; hypothetical protein. (570 aa)
accAacetyl-CoA carboxylase alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (326 aa)
alr52756-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (476 aa)
glcDGlycolate oxidase subunit; ORF_ID:alr5269; glcD gene product. (430 aa)
all51674-diphosphocytidyl-2C-methyl-D-erythritol synthase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (228 aa)
accBBiotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (182 aa)
alr48032-hydroxyhepta-2,4-diene-1,7-dioate isomerase; ORF_ID:alr4803. (257 aa)
all4667Dethiobiotin synthase; ORF_ID:all4667; hypothetical protein. (187 aa)
fdaFructose-1,6-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (359 aa)
all4520Anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (392 aa)
alr4455Alr4455 protein; 6-oxocamphor hydrolase; ORF_ID:alr4455. (253 aa)
all4443ORF_ID:all4443; hypothetical protein. (446 aa)
all4427ORF_ID:all4427; similar to phytanoyl-CoA hydroxylase. (311 aa)
all4391Enoyl-[acyl-carrier-protein] reductase; Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. (264 aa)
alr4385Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (241 aa)
alr4351Deoxyxylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (399 aa)
all42863-oxoacyl-[acyl-carrier-protein] synthase; ORF_ID:all4286; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (388 aa)
all4257Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (524 aa)
all4256Acetyl-coenzyme A synthetase; ORF_ID:all4256. (132 aa)
all41822,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (533 aa)
all4131Phosphoglycerate kinase; ORF_ID:all4131. (400 aa)
alr4059ORF_ID:alr4059; unknown protein. (126 aa)
all4008Pyruvate kinase; ORF_ID:all4008; Belongs to the pyruvate kinase family. (589 aa)
alr3926ORF_ID:alr3926; unknown protein. (442 aa)
alr38832-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (165 aa)
all3735Fructose-bisphosphate aldolase class I; ORF_ID:all3735. (360 aa)
alr3606Dihydrolipoamide S-acetyltransferase; ORF_ID:alr3606. (430 aa)
alr3602ORF_ID:alr3602; probable long-chain-fatty-acid--CoA ligase. (683 aa)
all3569Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (127 aa)
all3556Succinate-semialdehyde dehydrogenase; ORF_ID:all3556. (455 aa)
all3538Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa)
alr3419ORF_ID:alr3419; hypothetical protein. (228 aa)
alr3397Phosphoenolpyruvate synthase; ORF_ID:alr3397. (775 aa)
alr33433-oxoacyl-[acyl-carrier-protein] synthase beta chain; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (416 aa)
asr3342Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (84 aa)
all3341Heterodisulfide reductase, subunit B; ORF_ID:all3341. (301 aa)
alr32304-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (317 aa)
alr3147Phosphoenolpyruvate synthase; ORF_ID:alr3147. (163 aa)
alr3146Phosphoenolpyruvate synthase; ORF_ID:alr3146. (643 aa)
all3111Pantothenate metabolism flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (410 aa)
alr2973Glucokinase; ORF_ID:alr2973; Belongs to the bacterial glucokinase family. (342 aa)
alr2948ORF_ID:alr2948; putative zinc-binding oxidoreductase. (335 aa)
panCPantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. (534 aa)
alr2708Pyruvate dehydrogenase E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (344 aa)
alr2680Polyketide synthase; ORF_ID:alr2680. (2518 aa)
alr2679Polyketide synthase; ORF_ID:alr2679. (2478 aa)
all2646Polyketide synthase type I; ORF_ID:all2646. (1488 aa)
all2635Polyketide synthase type I; ORF_ID:all2635. (1565 aa)
gap1Glyceraldehyde-3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. (343 aa)
all2564Pyruvate kinase; ORF_ID:all2564; Belongs to the pyruvate kinase family. (476 aa)
all2509ORF_ID:all2509; similar to phosphoenolpyruvate synthase. (963 aa)
all25014-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin); Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (408 aa)
alr23984-aminobutyrate aminotransferase; ORF_ID:alr2398; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (431 aa)
accDacetyl-CoA carboxylase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (316 aa)
alr2331ORF_ID:alr2331; hypothetical protein. (218 aa)
Your Current Organism:
Nostoc sp. PCC7120
NCBI taxonomy Id: 103690
Other names: Anabaena sp. (ATCC 27893), Anabaena sp. (PCC 7120), Anabaena sp. DCC D0672, Anabaena sp. PCC 7120, Anabaena sp. SAG 25.82, Anabaena sp. UTEX B 2576, Anabaena variabilis UTCC 387, N. sp. PCC 7120, Nostoc muscorum ISU, Nostoc sp. AKM24, Nostoc sp. ATCC 27347, Nostoc sp. ATCC 72893, Nostoc sp. DSM 107007, Nostoc sp. Ind43, Nostoc sp. PCC 7120, Nostoc sp. SAG 25.82
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