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nifD nifD nifK nifK nifE nifE nifN nifN leuD leuD alr1410 alr1410 all1355 all1355 all1323 all1323 psbU psbU alr1155 alr1155 uvrB uvrB all1082 all1082 ndhD-2 ndhD-2 alr0819 alr0819 psbW psbW hoxF hoxF alr0751 alr0751 hupA hupA hupE hupE hypF hypF all0688 all0688 narB narB all0596 all0596 asr0505 asr0505 ilvB ilvB ruvA ruvA alr0331 alr0331 alr0051 alr0051 all0327 all0327 accA accA glcD glcD accB accB all5029 all5029 alr4932 alr4932 all4705 all4705 asr4648 asr4648 all4639 all4639 ilvG ilvG all4608 all4608 all4607 all4607 alr4602 alr4602 all4495 all4495 all4450 all4450 rpoA rpoA ndhD-4 ndhD-4 alr3993 alr3993 alr3965 alr3965 all3939 all3939 all3914 all3914 all3913 all3913 psbO psbO uvrA uvrA clpC clpC alr3668 alr3668 alr3625 alr3625 alr3623 alr3623 alr3618 alr3618 alr3606 alr3606 alr3593 alr3593 ilvB-2 ilvB-2 all3538 all3538 alr3477 alr3477 alr3476 alr3476 alr3473 alr3473 alr3444 alr3444 all3439 all3439 alr3413 alr3413 all3111 all3111 all3076 all3076 all2960 all2960 ruvB ruvB uvrC uvrC alr2710 alr2710 all2687 all2687 alr2377 alr2377 accD accD phnG phnG phnH phnH phnI phnI phnJ phnJ phnK phnK phnL phnL dnaN dnaN alr1845 alr1845 xseA xseA xseB xseB all1693 all1693 all1616 all1616 rpoC2 rpoC2 rpoC1 rpoC1 rpoB rpoB alr1521 alr1521
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
nifDNitrogenase molybdenum-iron protein alpha chain; This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation. (497 aa)
nifKNitrogenase molybdenum-iron protein beta chain; This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation; Belongs to the NifD/NifK/NifE/NifN family. (512 aa)
nifENitrogen Fe/Mo cofactor biosynthesis E; This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor); Belongs to the NifD/NifK/NifE/NifN family. (480 aa)
nifNNitrogenase olybdenum-iron protein; This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor); Belongs to the NifD/NifK/NifE/NifN family. (444 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (202 aa)
alr1410ORF_ID:alr1410; hypothetical protein. (188 aa)
all1355ORF_ID:all1355; hypothetical protein. (167 aa)
all1323DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (640 aa)
psbUPhotosystem II 12 kD extrinsic protein; Stabilizes the structure of photosystem II oxygen-evolving complex (OEC), the ion environment of oxygen evolution and protects the OEC against heat-induced inactivation. (149 aa)
alr1155Carbamoyl phosphate synthase small subunit; ORF_ID:alr1155; Belongs to the CarA family. (388 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (665 aa)
all1082Photosystem II reaction center Psb28 protein; ORF_ID:all1082; hypothetical protein; Belongs to the Psb28 family. (122 aa)
ndhD-2NADH dehydrogenase subunit 4; ORF_ID:alr0870. (500 aa)
alr0819ORF_ID:alr0819; putative invertase. (483 aa)
psbWPhotosystem II protein W; ORF_ID:all0801; Belongs to the Psb28 family. (111 aa)
hoxFHydrogenase subunit; ORF_ID:alr0752; hoxF gene product. (544 aa)
alr0751NADH dehydrogenase I chain E; ORF_ID:alr0751. (164 aa)
hupAHydrogenase expression/formation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (113 aa)
hupEHydrogenase expression/formation protein; ORF_ID:alr0698; hupE gene product. (367 aa)
hypFHydrogenase maturation protein; ORF_ID:alr0694; hypF gene product. (785 aa)
all0688[NiFe] uptake hydrogenase small subunit; ORF_ID:all0688; hupS gene product. (320 aa)
narBNitrate reductase; ORF_ID:alr0612; narB gene product; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. (746 aa)
all0596ORF_ID:all0596; unknown protein. (219 aa)
asr0505ORF_ID:asr0505; unknown protein. (58 aa)
ilvBAcetolactate synthase large subunit; ORF_ID:all0427; ilvB gene product; Belongs to the TPP enzyme family. (629 aa)
ruvAHolliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (213 aa)
alr0331ORF_ID:alr0331; hypothetical protein. (761 aa)
alr0051IMP dehydrogenase; ORF_ID:alr0051. (387 aa)
all0327ORF_ID:all0327; hypothetical protein. (259 aa)
accAacetyl-CoA carboxylase alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (326 aa)
glcDGlycolate oxidase subunit; ORF_ID:alr5269; glcD gene product. (430 aa)
accBBiotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (182 aa)
all5029ORF_ID:all5029; hypothetical protein. (157 aa)
alr4932DNA polymerase III gamma and tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (655 aa)
all4705All4705 protein; DNA polymerase III, delta prime subunit; ORF_ID:all4705. (320 aa)
asr4648DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (78 aa)
all4639ORF_ID:all4639; hypothetical protein. (687 aa)
ilvGAcetohydroxy acid synthase; ORF_ID:all4613; ilvG gene product. (632 aa)
all4608Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (130 aa)
all4607Glycine cleavage system protein P; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (983 aa)
alr4602Type I site-specific deoxyribonuclease chain S; ORF_ID:alr4602. (390 aa)
all4495DNA helicase II; ORF_ID:all4495. (772 aa)
all4450Ribonuclease II; ORF_ID:all4450. (686 aa)
rpoARNA polymerase alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (315 aa)
ndhD-4NADH dehydrogenase subunit 4; ORF_ID:alr4157. (500 aa)
alr39936,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (190 aa)
alr3965ORF_ID:alr3965; unknown protein. (285 aa)
all3939ORF_ID:all3939; hypothetical protein. (315 aa)
all3914succinyl-CoA synthetase beta chain; ORF_ID:all3914. (408 aa)
all3913succinyl-CoA synthetase alpha chain; ORF_ID:all3913. (293 aa)
psbOManganese-stabilzing protein precursor; MSP binds to a putative Mn-binding protein and keeps 2 of the 4 Mn-atoms associated with PSII. (273 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (961 aa)
clpCATP-dependent Clp protease regulatory subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (445 aa)
alr3668Urease beta subunit; ORF_ID:alr3668; Belongs to the urease beta subunit family. (108 aa)
alr3625ORF_ID:alr3625; similar to type I site-specific deoxyribonuclease. (353 aa)
alr3623ORF_ID:alr3623; similar to type I site-specific deoxyribonuclease. (146 aa)
alr3618Type I restriction-modification enzyme R subunit; ORF_ID:alr3618. (776 aa)
alr3606Dihydrolipoamide S-acetyltransferase; ORF_ID:alr3606. (430 aa)
alr3593Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (736 aa)
ilvB-2Acetolactate synthase; ORF_ID:all3555; ilvB gene product; Belongs to the TPP enzyme family. (547 aa)
all3538Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa)
alr3477Type I restriction-modification enzyme S subunit; ORF_ID:alr3477. (383 aa)
alr3476Type I restriction-modification enzyme S subunit; ORF_ID:alr3476. (99 aa)
alr3473Type I restriction-modification enzyme R subunit; ORF_ID:alr3473. (776 aa)
alr3444ORF_ID:alr3444; hypothetical protein. (329 aa)
all3439ORF_ID:all3439; unknown protein. (125 aa)
alr3413Ribonuclease P; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (140 aa)
all3111Pantothenate metabolism flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (410 aa)
all3076ORF_ID:all3076; similar to photosystem II oxygen-evolving complex 23K protein PsbP. (246 aa)
all2960ORF_ID:all2960; unknown protein. (248 aa)
ruvBHolliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (366 aa)
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (627 aa)
alr2710ORF_ID:alr2710; hypothetical protein. (279 aa)
all2687Type I restriction-modification enzyme S subunit; ORF_ID:all2687. (427 aa)
alr2377Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (493 aa)
accDacetyl-CoA carboxylase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (316 aa)
phnGPhosphonate metabolism protein; ORF_ID:all2225; phnG gene product. (151 aa)
phnHPhosphonate metabolism protein; ORF_ID:all2224; phnH gene product. (199 aa)
phnIPhosphonate metabolism protein; ORF_ID:all2222; phnI gene product. (415 aa)
phnJPhosphonate metabolism protein; ORF_ID:all2219; phnJ gene product. (288 aa)
phnKPhosphonate ABC transporter, ATP-binding component; ORF_ID:all2218; phnK gene product. (257 aa)
phnLPhosphonate ABC transporter, ATP-binding component; ORF_ID:all2217; phnL gene product. (241 aa)
dnaNDNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (387 aa)
alr1845tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (219 aa)
xseAExodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (412 aa)
xseBExodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (88 aa)
all1693Glycerol-3-phosphate dehydrogenase; ORF_ID:all1693; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (307 aa)
all1616ORF_ID:all1616; hypothetical protein. (227 aa)
rpoC2RNA polymerase beta prime subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the RNA polymerase beta' chain family. RpoC2 subfamily. (1350 aa)
rpoC1RNA polymerase gamma subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (625 aa)
rpoBRNA polymerase beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1131 aa)
alr1521ORF_ID:alr1521; putative invertase. (468 aa)
Your Current Organism:
Nostoc sp. PCC7120
NCBI taxonomy Id: 103690
Other names: Anabaena sp. (ATCC 27893), Anabaena sp. (PCC 7120), Anabaena sp. DCC D0672, Anabaena sp. PCC 7120, Anabaena sp. SAG 25.82, Anabaena sp. UTEX B 2576, Anabaena variabilis UTCC 387, N. sp. PCC 7120, Nostoc muscorum ISU, Nostoc sp. AKM24, Nostoc sp. ATCC 27347, Nostoc sp. ATCC 72893, Nostoc sp. DSM 107007, Nostoc sp. Ind43, Nostoc sp. PCC 7120, Nostoc sp. SAG 25.82
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