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desA desA clpB-3 clpB-3 alr3393 alr3393 avaIM avaIM groES groES groEL-2 groEL-2 gltS gltS dnaK-5 dnaK-5 hepK hepK dnaJ-5 dnaJ-5 desC-2 desC-2 clpB-4 clpB-4 clpB clpB groEL groEL dnaK-2 dnaK-2 desC desC dnaJ dnaJ alr1414 alr1414 dnaK dnaK all0860 all0860 all0441 all0441 alr2271 alr2271 all2070 all2070 clpB-2 clpB-2 fraC fraC dnaK-3 dnaK-3 dnaJ-2 dnaJ-2 dnaK-4 dnaK-4 dnaJ-3 dnaJ-3 dnaJ-4 dnaJ-4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
desAPhosphatidylcholine desaturase; ORF_ID:all1598; desA gene product. (350 aa)
clpB-3Endopeptidase Clp ATP-binding chain; ORF_ID:alr2999; Belongs to the ClpA/ClpB family. (839 aa)
alr3393ORF_ID:alr3393; similar to serum-resistance protein BrkB. (314 aa)
avaIMSite-specific DNA-methyltransferase (cytosine-specific); This methylase recognizes the double-stranded sequence CYCGRG, causes specific methylation on C-? on both strands, and protects the DNA from cleavage by the AvaI endonuclease; Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily. (482 aa)
groESChaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (103 aa)
groEL-2Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (544 aa)
gltSFerredoxin-glutamate synthase; ORF_ID:alr4344. (1559 aa)
dnaK-5DnaK-type molecular chaperone; ORF_ID:all4477; dnaK gene product; Belongs to the heat shock protein 70 family. (712 aa)
hepKTwo-component system sensory histidine kinase; ORF_ID:all4496; hepK gene product. (575 aa)
dnaJ-5Chaperone DnaJ protein; ORF_ID:all4643. (333 aa)
desC-2Delta-9 desaturase; ORF_ID:all4991. (285 aa)
clpB-4Endopeptidase Clp ATP-binding chain B; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/ClpB [...] (835 aa)
clpBEndopeptidase Clp ATP-binding chain; ORF_ID:alr1963; Belongs to the ClpA/ClpB family. (814 aa)
groELChaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (560 aa)
dnaK-2DnaK-type molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. (633 aa)
desCDelta-9 desaturase; ORF_ID:all1599; desC gene product. (272 aa)
dnaJChaperone protein; ORF_ID:all1488; dnaJ gene product. (315 aa)
alr1414Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (425 aa)
dnaKDnaK-type molecular chaperone; ORF_ID:alr1264; dnaK gene product; Belongs to the heat shock protein 70 family. (532 aa)
all0860DNA gyrase A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (872 aa)
all0441DNA topoisomerase chain A; ORF_ID:all0441. (835 aa)
alr2271(3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (171 aa)
all2070ORF_ID:all2070; hypothetical protein. (301 aa)
clpB-2Endopeptidase Clp ATP-binding chain; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/ClpB family. (880 aa)
fraCFilament integrity protein; Involved in filament integrity. Required for the integrity of cell junctions in general but is apparently not directly involved in normal differentiation and nitrogen fixation. (179 aa)
dnaK-3DnaK-type molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. (653 aa)
dnaJ-2DnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] (376 aa)
dnaK-4DnaK-type molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. (688 aa)
dnaJ-3DnaJ protein; ORF_ID:alr2991. (333 aa)
dnaJ-4DnaJ protein; ORF_ID:alr2993. (167 aa)
Your Current Organism:
Nostoc sp. PCC7120
NCBI taxonomy Id: 103690
Other names: Anabaena sp. (ATCC 27893), Anabaena sp. (PCC 7120), Anabaena sp. DCC D0672, Anabaena sp. PCC 7120, Anabaena sp. SAG 25.82, Anabaena sp. UTEX B 2576, Anabaena variabilis UTCC 387, N. sp. PCC 7120, Nostoc muscorum ISU, Nostoc sp. AKM24, Nostoc sp. ATCC 27347, Nostoc sp. ATCC 72893, Nostoc sp. DSM 107007, Nostoc sp. Ind43, Nostoc sp. PCC 7120, Nostoc sp. SAG 25.82
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