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hglK hglK patA patA devR devR psbV psbV hepA hepA hetC hetC gap1 gap1 alr2542 alr2542 patB patB fraC fraC hetR hetR glnA glnA patS patS icd icd rbcS rbcS alr1521 alr1521 alr1519 alr1519 nifB nifB nifU nifU nifH nifH nifD nifD nifK nifK psbU psbU alr1105 alr1105 gap3 gap3 all1059 all1059 psbY psbY ccmM ccmM ccmK-2 ccmK-2 psbH psbH alr0819 alr0819 psbW psbW psbB psbB psaF psaF psaJ psaJ psaA psaA hetN hetN gap2 gap2 susA susA psbAI psbAI psbD-2 psbD-2 hepK hepK ntcA ntcA all4376 all4376 psbC psbC psbD psbD all4289 all4289 alr4255 alr4255 alr3952 alr3952 asr3935 asr3935 psbO psbO psbJ psbJ psbA psbA devC devC alr3644 alr3644 hetF hetF all3193 all3193
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hglKHeterocyst-specific glycolipids-directing protein; ORF_ID:all0813; hglK gene product. (727 aa)
patATwo-component response regulator, heterocyst pattern formation protein; Controls heterocyst pattern formation. Required for the differentiation of intercalary heterocysts but not for terminal heterocysts. (379 aa)
devRTwo-component system, regulatory protein; ORF_ID:alr0442; devR gene product. (134 aa)
psbVCytochrome c550; Low-potential cytochrome c that plays a role in the oxygen- evolving complex of photosystem II. (163 aa)
hepAATP-binding protein; Acts early in the process of morphological differentiation of heterocysts. (607 aa)
hetCHeterocyst differentiation protein; ORF_ID:alr2817; hetC gene product. (1044 aa)
gap1Glyceraldehyde-3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. (343 aa)
alr2542Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (278 aa)
patBTranscriptional regulator; ORF_ID:all2512; patB gene product. (529 aa)
fraCFilament integrity protein; Involved in filament integrity. Required for the integrity of cell junctions in general but is apparently not directly involved in normal differentiation and nitrogen fixation. (179 aa)
hetRHeterocyst differentiation protein; Controls heterocyst differentiation. Has both a protease and a DNA-binding activity. Binds the promoter regions of hetR, hepA and patS. (299 aa)
glnAGlutamate--ammonia ligase; Involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. (474 aa)
patSHeterocyst-inhibiting signaling peptide; Inhibits heterocyst differentiation. Seems to control heterocyst pattern formation through intercellular signaling mechanisms. In Anabaena filaments every 10th vegetative cell terminally differentiates into a heterocyst specialized for nitrogen fixation. Seems to inhibit the formation of adjacent heterocysts. Inhibits the DNA-binding of HetR. (17 aa)
icdIsocitrate dehydrogenase; ORF_ID:alr1827; icd gene product. (473 aa)
rbcSRibulose 1,5-bisphosphate carboxylase/oxygenase small subunit; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site (By similarity); Belongs to the RuBisCO small chain family. (109 aa)
alr1521ORF_ID:alr1521; putative invertase. (468 aa)
alr1519Amino acid transporter; ORF_ID:alr1519. (455 aa)
nifBNitrogen fixation protein; Involved in the biosynthesis of the iron-molybdenum cofactor (FeMo-co or M-cluster) found in the dinitrogenase enzyme of the nitrogenase complex in nitrogen-fixing microorganisms. NifB catalyzes the crucial step of radical SAM-dependent carbide insertion that occurs concomitant with the insertion of a 9th sulfur and the rearrangement/coupling of two [4Fe-4S] clusters into a [8Fe-9S-C] cluster, the precursor to the M-cluster. (475 aa)
nifUNitrogen fixation protein; May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins. (300 aa)
nifHNitrogenase iron protein; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein. (295 aa)
nifDNitrogenase molybdenum-iron protein alpha chain; This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation. (497 aa)
nifKNitrogenase molybdenum-iron protein beta chain; This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation; Belongs to the NifD/NifK/NifE/NifN family. (512 aa)
psbUPhotosystem II 12 kD extrinsic protein; Stabilizes the structure of photosystem II oxygen-evolving complex (OEC), the ion environment of oxygen evolution and protects the OEC against heat-induced inactivation. (149 aa)
alr1105Arsenate reductase; ORF_ID:alr1105; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (131 aa)
gap3Glyceraldehyde-3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-phosphate dehydrogenase [...] (337 aa)
all1059Sucrose synthase; ORF_ID:all1059. (805 aa)
psbYPhotosystem II protein Y; Manganese-binding polypeptide with L-arginine metabolizing enzyme activity. Component of the core of photosystem II. Belongs to the PsbY family. (41 aa)
ccmMCarbon dioxide concentrating mechanism protein; ORF_ID:all0865; ccmM gene product. (555 aa)
ccmK-2Carbon dioxide concentrating mechanism protein; ORF_ID:all0863; ccmK gene product. (271 aa)
psbHPhotosystem II protein; One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly. PSII is a light- driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. (62 aa)
alr0819ORF_ID:alr0819; putative invertase. (483 aa)
psbWPhotosystem II protein W; ORF_ID:all0801; Belongs to the Psb28 family. (111 aa)
psbBPhotosystem II CP47 protein; One of the components of the core complex of photosystem II (PSII). It binds chlorophyll and helps catalyze the primary light- induced photochemical processes of PSII. PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation; Belongs to the PsbB/PsbC family. PsbB subfamily. (509 aa)
psaFPhotosystem I subunit III precursor; Probably participates in efficiency of electron transfer from plastocyanin to P700 (or cytochrome c553 in algae and cyanobacteria). This plastocyanin-docking protein contributes to the specific association of plastocyanin to PSI; Belongs to the PsaF family. (164 aa)
psaJPhotosystem I subunit IX; May help in the organization of the PsaE and PsaF subunits. Belongs to the PsaJ family. (49 aa)
psaAPhotosystem I core protein A1; PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6. (752 aa)
hetNKetoacyl reductase; May be involved in repressing heterocyst differentiation and may be essential for preventing all vegetative cells from differentiating. (287 aa)
gap2Glyceraldehyde-3-phosphate dehydrogenase; Gap2 has a major role in carbon fixation as a component of the Calvin cycle. Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NADP. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NADP to NADPH. The reduced NADPH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic p [...] (337 aa)
susASucrose synthase; ORF_ID:all4985. (806 aa)
psbAIPhotosystem II protein D1; Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors. (360 aa)
psbD-2Photosystem II protein D2; ORF_ID:alr4548. (351 aa)
hepKTwo-component system sensory histidine kinase; ORF_ID:all4496; hepK gene product. (575 aa)
ntcANitrogen-responsive regulatory protein; Required for full expression of proteins subject to ammonium repression. Transcriptional activator of genes subject to nitrogen control. (223 aa)
all4376Sucrose-phosphate synthase; ORF_ID:all4376; probable glycosyl transferase. (422 aa)
psbCPhotosystem II CP43 protein; One of the components of the core complex of photosystem II (PSII). It binds chlorophyll and helps catalyze the primary light- induced photochemical processes of PSII. PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation; Belongs to the PsbB/PsbC family. PsbC subfamily. (459 aa)
psbDPhotosystem II protein D2; Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors. D2 is needed for assembly of a stable PSII complex. (351 aa)
all4289Photosystem I assembly protein Ycf4; Seems to be required for the assembly of the photosystem I complex; Belongs to the Ycf4 family. (198 aa)
alr4255Glutamate dehydrogenase; ORF_ID:alr4255; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (437 aa)
alr3952Transcriptional regulator; ORF_ID:alr3952. (239 aa)
asr3935DNA binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. It is essential for heterocyst differentiation; Belongs to the bacterial histone-like protein family. (94 aa)
psbOManganese-stabilzing protein precursor; MSP binds to a putative Mn-binding protein and keeps 2 of the 4 Mn-atoms associated with PSII. (273 aa)
psbJPhotosystem II protein J; One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. (40 aa)
psbAPhotosystem II protein D1; Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors. (360 aa)
devCHeterocyst specific ABC-transporter, membrane spanning subunit; ORF_ID:alr3711; devC gene product. (385 aa)
alr3644Aspartate kinase; ORF_ID:alr3644. (606 aa)
hetFHeterocyst differentiation protein; ORF_ID:alr3546; hetF gene product. (779 aa)
all3193Photosystem I assembly protein Ycf3; Essential for the assembly of the photosystem I (PSI) complex. May act as a chaperone-like factor to guide the assembly of the PSI subunits; Belongs to the Ycf3 family. (173 aa)
Your Current Organism:
Nostoc sp. PCC7120
NCBI taxonomy Id: 103690
Other names: Anabaena sp. (ATCC 27893), Anabaena sp. (PCC 7120), Anabaena sp. DCC D0672, Anabaena sp. PCC 7120, Anabaena sp. SAG 25.82, Anabaena sp. UTEX B 2576, Anabaena variabilis UTCC 387, N. sp. PCC 7120, Nostoc muscorum ISU, Nostoc sp. AKM24, Nostoc sp. ATCC 27347, Nostoc sp. ATCC 72893, Nostoc sp. DSM 107007, Nostoc sp. Ind43, Nostoc sp. PCC 7120, Nostoc sp. SAG 25.82
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