STRINGSTRING
alr2765 alr2765 all2444 all2444 pilT pilT all2367 all2367 glnA glnA glnB glnB alr2205 alr2205 all1950 all1950 all1893 all1893 alr1879 alr1879 all1866 all1866 ccmK-2 ccmK-2 ccmM ccmM psbK psbK all0888 all0888 psbU psbU all1267 all1267 all1368 all1368 rbcS rbcS devB devB icd icd alr5103 alr5103 gap2 gap2 ndhD-5 ndhD-5 alr4908 alr4908 pepC pepC alr4853 alr4853 secA secA argG argG agp agp ntcA ntcA alr4385 alr4385 ndhF-3 ndhF-3 all4131 all4131 prk prk zwf zwf ndhD-3 ndhD-3 alr3955 alr3955 cphA-2 cphA-2 psbO psbO sigD sigD alr3667 alr3667 all3538 all3538 ndhH ndhH pilT-2 pilT-2 all3255 all3255 gap1 gap1 trxA trxA psbT psbT psbB psbB gltA gltA cpcB cpcB cphA cphA nirA nirA narB narB glgB glgB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
alr2765Aminotransferase; ORF_ID:alr2765. (403 aa)
all2444General secretion pathway protein E; ORF_ID:all2444. (670 aa)
pilTTwitching motility protein; ORF_ID:all2443; pilT gene product. (372 aa)
all2367Thioredoxin; ORF_ID:all2367; Belongs to the thioredoxin family. (108 aa)
glnAGlutamate--ammonia ligase; Involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. (474 aa)
glnBNitrogen regulatory protein P-II; ORF_ID:all2319. (112 aa)
alr2205Thioredoxin; ORF_ID:alr2205; Belongs to the thioredoxin family. (113 aa)
all1950Permease protein of ABC transporter; ORF_ID:all1950; Belongs to the binding-protein-dependent transport system permease family. (386 aa)
all1893Thioredoxin; ORF_ID:all1893; Belongs to the thioredoxin family. (105 aa)
alr1879Glycogen synthase; Synthesizes alpha-1,4-glucan chains using ADP-glucose. (472 aa)
all1866Thioredoxin; ORF_ID:all1866; Belongs to the thioredoxin family. (110 aa)
ccmK-2Carbon dioxide concentrating mechanism protein; ORF_ID:all0863; ccmK gene product. (271 aa)
ccmMCarbon dioxide concentrating mechanism protein; ORF_ID:all0865; ccmM gene product. (555 aa)
psbKPhotosystem II protein; One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. (45 aa)
all0888Ribose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (236 aa)
psbUPhotosystem II 12 kD extrinsic protein; Stabilizes the structure of photosystem II oxygen-evolving complex (OEC), the ion environment of oxygen evolution and protects the OEC against heat-induced inactivation. (149 aa)
all1267Aconitate hydratase; ORF_ID:all1267; Belongs to the aconitase/IPM isomerase family. (876 aa)
all1368Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (211 aa)
rbcSRibulose 1,5-bisphosphate carboxylase/oxygenase small subunit; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site (By similarity); Belongs to the RuBisCO small chain family. (109 aa)
devBglucose-6-P-dehydrogenase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily. (240 aa)
icdIsocitrate dehydrogenase; ORF_ID:alr1827; icd gene product. (473 aa)
alr5103Aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (411 aa)
gap2Glyceraldehyde-3-phosphate dehydrogenase; Gap2 has a major role in carbon fixation as a component of the Calvin cycle. Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NADP. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NADP to NADPH. The reduced NADPH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic p [...] (337 aa)
ndhD-5NADH dehydrogenase subunit 4; NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity); Belongs to the complex I subunit 4 family. (560 aa)
alr4908SOS function regulatory protein, LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (201 aa)
pepCPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (982 aa)
alr4853Aspartate aminotransferase; ORF_ID:alr4853. (388 aa)
secAPreprotein translocase SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. (930 aa)
argGArgininosuccinate synthase; ORF_ID:alr4798; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (400 aa)
agpGlucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. (429 aa)
ntcANitrogen-responsive regulatory protein; Required for full expression of proteins subject to ammonium repression. Transcriptional activator of genes subject to nitrogen control. (223 aa)
alr4385Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (241 aa)
ndhF-3NADH dehydrogenase subunit 5; ORF_ID:alr4156. (620 aa)
all4131Phosphoglycerate kinase; ORF_ID:all4131. (400 aa)
prkPhosphoribulokinase; ORF_ID:alr4123. (334 aa)
zwfGlucose 6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (509 aa)
ndhD-3NADH dehydrogenase subunit 4; NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity); Belongs to the complex I subunit 4 family. (525 aa)
alr3955Thioredoxin; ORF_ID:alr3955. (128 aa)
cphA-2Cyanophycin synthetase; Catalyzes the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer); In the C-terminal section; belongs to the MurCDEF family. (901 aa)
psbOManganese-stabilzing protein precursor; MSP binds to a putative Mn-binding protein and keeps 2 of the 4 Mn-atoms associated with PSII. (273 aa)
sigDGroup 2 sigma 70-type sigma factor D; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (332 aa)
alr3667Urease gamma subunit; ORF_ID:alr3667; Belongs to the urease gamma subunit family. (100 aa)
all3538Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa)
ndhHNADH dehydrogenase subunit 7; NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration. (394 aa)
pilT-2Twitching motility protein; ORF_ID:all3329; pilT gene product. (432 aa)
all3255Transport protein; ORF_ID:all3255. (220 aa)
gap1Glyceraldehyde-3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. (343 aa)
trxAThioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. (107 aa)
psbTPhotosystem II PsbT protein; Seems to play a role in the dimerization of PSII. Belongs to the PsbT family. (35 aa)
psbBPhotosystem II CP47 protein; One of the components of the core complex of photosystem II (PSII). It binds chlorophyll and helps catalyze the primary light- induced photochemical processes of PSII. PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation; Belongs to the PsbB/PsbC family. PsbB subfamily. (509 aa)
gltACitrate synthase; ORF_ID:alr0222; gltA gene product; Belongs to the citrate synthase family. (378 aa)
cpcBPhycocyanin beta chain; Light-harvesting photosynthetic bile pigment-protein from the phycobiliprotein complex. (173 aa)
cphACyanophycin synthetase; ORF_ID:alr0573; cphA gene product. (636 aa)
nirANitrite reductase; ORF_ID:alr0607; nirA gene product; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (536 aa)
narBNitrate reductase; ORF_ID:alr0612; narB gene product; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. (746 aa)
glgB1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. (764 aa)
Your Current Organism:
Nostoc sp. PCC7120
NCBI taxonomy Id: 103690
Other names: Anabaena sp. (ATCC 27893), Anabaena sp. (PCC 7120), Anabaena sp. DCC D0672, Anabaena sp. PCC 7120, Anabaena sp. SAG 25.82, Anabaena sp. UTEX B 2576, Anabaena variabilis UTCC 387, N. sp. PCC 7120, Nostoc muscorum ISU, Nostoc sp. AKM24, Nostoc sp. ATCC 27347, Nostoc sp. ATCC 72893, Nostoc sp. DSM 107007, Nostoc sp. Ind43, Nostoc sp. PCC 7120, Nostoc sp. SAG 25.82
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.