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hetR hetR patB patB hetC hetC alr2822 alr2822 alr2841 alr2841 rpoA rpoA all4272 all4272 alr4370 alr4370 ntcA ntcA hetI hetI all5341 all5341 all0373 all0373 patA patA hoxH hoxH alr1010 alr1010 asr1131 asr1131 alr1358 alr1358 all1424 all1424 all1427 all1427 hesB hesB nifW nifW nifK nifK nifH nifH nifB nifB asr1734 asr1734 patS patS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
hetRHeterocyst differentiation protein; Controls heterocyst differentiation. Has both a protease and a DNA-binding activity. Binds the promoter regions of hetR, hepA and patS. (299 aa)
patBTranscriptional regulator; ORF_ID:all2512; patB gene product. (529 aa)
hetCHeterocyst differentiation protein; ORF_ID:alr2817; hetC gene product. (1044 aa)
alr2822ORF_ID:alr2822; hypothetical protein. (224 aa)
alr2841ORF_ID:alr2841; unknown protein. (474 aa)
rpoARNA polymerase alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (315 aa)
all4272Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (376 aa)
alr4370Serine/threonine protein phosphatase; ORF_ID:alr4370. (251 aa)
ntcANitrogen-responsive regulatory protein; Required for full expression of proteins subject to ammonium repression. Transcriptional activator of genes subject to nitrogen control. (223 aa)
hetIPhosphopantetheinyltransferase family; Probably activates the acyl carrier protein (ACP) domain of HetM, by transferring the 4'-phosphopantetheinyl moiety of coenzyme A (CoA) to a serine residue. May be required for maintaining vegetative growth and probably acts via HetN to inhibit differentiation. (160 aa)
all5341ORF_ID:all5341; probable glycosyl transferase. (421 aa)
all0373Serine/threonine protein phosphatase; ORF_ID:all0373. (334 aa)
patATwo-component response regulator, heterocyst pattern formation protein; Controls heterocyst pattern formation. Required for the differentiation of intercalary heterocysts but not for terminal heterocysts. (379 aa)
hoxHHydrogenase large subunit; ORF_ID:alr0766; hoxH gene product. (483 aa)
alr1010ORF_ID:alr1010; unknown protein. (126 aa)
asr1131ORF_ID:asr1131; hypothetical protein. (77 aa)
alr1358Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase 1; Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME); Belongs to the AcsF family. (351 aa)
all1424ORF_ID:all1424; unknown protein. (124 aa)
all1427ORF_ID:all1427; hypothetical protein. (197 aa)
hesBHesB protein; May be required for efficient nitrogen fixation. (123 aa)
nifWNitrogen fixation protein; May protect the nitrogenase Fe-Mo protein from oxidative damage; Belongs to the NifW family. (105 aa)
nifKNitrogenase molybdenum-iron protein beta chain; This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation; Belongs to the NifD/NifK/NifE/NifN family. (512 aa)
nifHNitrogenase iron protein; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein. (295 aa)
nifBNitrogen fixation protein; Involved in the biosynthesis of the iron-molybdenum cofactor (FeMo-co or M-cluster) found in the dinitrogenase enzyme of the nitrogenase complex in nitrogen-fixing microorganisms. NifB catalyzes the crucial step of radical SAM-dependent carbide insertion that occurs concomitant with the insertion of a 9th sulfur and the rearrangement/coupling of two [4Fe-4S] clusters into a [8Fe-9S-C] cluster, the precursor to the M-cluster. (475 aa)
asr1734ORF_ID:asr1734; unknown protein. (93 aa)
patSHeterocyst-inhibiting signaling peptide; Inhibits heterocyst differentiation. Seems to control heterocyst pattern formation through intercellular signaling mechanisms. In Anabaena filaments every 10th vegetative cell terminally differentiates into a heterocyst specialized for nitrogen fixation. Seems to inhibit the formation of adjacent heterocysts. Inhibits the DNA-binding of HetR. (17 aa)
Your Current Organism:
Nostoc sp. PCC7120
NCBI taxonomy Id: 103690
Other names: Anabaena sp. (ATCC 27893), Anabaena sp. (PCC 7120), Anabaena sp. DCC D0672, Anabaena sp. PCC 7120, Anabaena sp. SAG 25.82, Anabaena sp. UTEX B 2576, Anabaena variabilis UTCC 387, N. sp. PCC 7120, Nostoc muscorum ISU, Nostoc sp. AKM24, Nostoc sp. ATCC 27347, Nostoc sp. ATCC 72893, Nostoc sp. DSM 107007, Nostoc sp. Ind43, Nostoc sp. PCC 7120, Nostoc sp. SAG 25.82
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