STRINGSTRING
ntcA ntcA alr0029 alr0029 all0061 all0061 alr0106 alr0106 petJ petJ alr0247 alr0247 petJ-2 petJ-2 alr0280 alr0280 all0283 all0283 all0284 all0284 alr0308 alr0308 alr0477 alr0477 all0478 all0478 ntcB ntcB nirA nirA nrtA nrtA nrtC nrtC narB narB all0664 all0664 ndhD-2 ndhD-2 all1062 all1062 dmnB dmnB alr1158 alr1158 psbI psbI cynS cynS rbcL rbcL rbcS rbcS alr1675 alr1675 sigC sigC dnaK-2 dnaK-2 groEL groEL clpB clpB all2124 all2124 patS patS glnB glnB clpB-2 clpB-2 glnA glnA hetR hetR all2352 all2352 dnaK-3 dnaK-3 kaiC kaiC dnaK-4 dnaK-4 clpB-3 clpB-3 nrtA-2 nrtA-2 nrtC-2 nrtC-2 alr3466 alr3466 groEL-2 groEL-2 sigD sigD alr3812 alr3812 mutT-2 mutT-2 ndhD-3 ndhD-3 pex pex isiA isiA hrcA hrcA all4107 all4107 cytA cytA all4272 all4272 all4289 all4289 psbD psbD dnaK-5 dnaK-5 psbD-2 psbD-2 alr4559 alr4559 secA secA clpB-4 clpB-4 pmbA pmbA glcD glcD alr5287 alr5287
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ntcANitrogen-responsive regulatory protein; Required for full expression of proteins subject to ammonium repression. Transcriptional activator of genes subject to nitrogen control. (223 aa)
alr0029WD-40 repeat protein; ORF_ID:alr0029. (1227 aa)
all0061Site-specific DNA-methyltransferase; ORF_ID:all0061. (277 aa)
alr0106Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (199 aa)
petJCytochrome c6; ORF_ID:all0161; Belongs to the cytochrome c family. PetJ subfamily. (111 aa)
alr0247WD-40 repeat protein; ORF_ID:alr0247. (304 aa)
petJ-2Cytochrome c6; ORF_ID:asl0256. (35 aa)
alr0280Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (228 aa)
all0283WD-40 repeat protein; ORF_ID:all0283. (1747 aa)
all0284WD-40 repeat protein; ORF_ID:all0284. (1711 aa)
alr03085-methyltetrahydrofolate--homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1178 aa)
alr0477phospho-N-acetylmuramoyl-pentapeptide- transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (261 aa)
all0478WD-40 repeat protein; ORF_ID:all0478. (1708 aa)
ntcBNitrogen assimilation transcriptional activator; ORF_ID:all0602; ntcB gene product; Belongs to the LysR transcriptional regulatory family. (312 aa)
nirANitrite reductase; ORF_ID:alr0607; nirA gene product; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (536 aa)
nrtANitrate transport nitrate-binding protein; Part of the ABC transporter complex NrtABCD involved in nitrate uptake. The complex is probably also involved in nitrite transport. NrtA is the substrate-binding protein. (440 aa)
nrtCNitrate transport ATP-binding protein; ORF_ID:alr0610; nrtC gene product. (657 aa)
narBNitrate reductase; ORF_ID:alr0612; narB gene product; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. (746 aa)
all0664WD-40 repeat protein; ORF_ID:all0664. (934 aa)
ndhD-2NADH dehydrogenase subunit 4; ORF_ID:alr0870. (500 aa)
all1062Peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity). (163 aa)
dmnBCytosine-specific DNA methyltransferase; ORF_ID:alr1152; dmnB gene product. (293 aa)
alr1158Mini-ribonuclease 3; Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors; Belongs to the MrnC RNase family. (161 aa)
psbIPhotosystem II protein; One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly. PSII is a light- driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. (38 aa)
cynSCyanate lyase; Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide; Belongs to the cyanase family. (146 aa)
rbcLRibulose-1,5-bisphosphate carboxylase/oxygenase large subunit; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site. Belongs to the RuBisCO large chain family. Type I subfamily. (476 aa)
rbcSRibulose 1,5-bisphosphate carboxylase/oxygenase small subunit; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site (By similarity); Belongs to the RuBisCO small chain family. (109 aa)
alr1675protein-methionine-S-oxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity). (222 aa)
sigCRNA polymerase sigma-subunit; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (416 aa)
dnaK-2DnaK-type molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. (633 aa)
groELChaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (560 aa)
clpBEndopeptidase Clp ATP-binding chain; ORF_ID:alr1963; Belongs to the ClpA/ClpB family. (814 aa)
all2124WD-40 repeat protein; ORF_ID:all2124. (1683 aa)
patSHeterocyst-inhibiting signaling peptide; Inhibits heterocyst differentiation. Seems to control heterocyst pattern formation through intercellular signaling mechanisms. In Anabaena filaments every 10th vegetative cell terminally differentiates into a heterocyst specialized for nitrogen fixation. Seems to inhibit the formation of adjacent heterocysts. Inhibits the DNA-binding of HetR. (17 aa)
glnBNitrogen regulatory protein P-II; ORF_ID:all2319. (112 aa)
clpB-2Endopeptidase Clp ATP-binding chain; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/ClpB family. (880 aa)
glnAGlutamate--ammonia ligase; Involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. (474 aa)
hetRHeterocyst differentiation protein; Controls heterocyst differentiation. Has both a protease and a DNA-binding activity. Binds the promoter regions of hetR, hepA and patS. (299 aa)
all2352WD-40 repeat protein; ORF_ID:all2352. (357 aa)
dnaK-3DnaK-type molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. (653 aa)
kaiCCircadian oscillation regulator; Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction; Belongs to the KaiC family. (519 aa)
dnaK-4DnaK-type molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. (688 aa)
clpB-3Endopeptidase Clp ATP-binding chain; ORF_ID:alr2999; Belongs to the ClpA/ClpB family. (839 aa)
nrtA-2Nitrate-binding protein; ORF_ID:all3333; nrtA gene product. (427 aa)
nrtC-2Nitrate transport ATP-binding protein of ABC transporter; ORF_ID:all3334; nrtC gene product. (263 aa)
alr3466WD-40 repeat protein; ORF_ID:alr3466. (1526 aa)
groEL-2Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (544 aa)
sigDGroup 2 sigma 70-type sigma factor D; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (332 aa)
alr3812Mutator MutT protein; ORF_ID:alr3812. (110 aa)
mutT-2Mutator protein; ORF_ID:all3870; mutT gene product; Belongs to the Nudix hydrolase family. (143 aa)
ndhD-3NADH dehydrogenase subunit 4; NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity); Belongs to the complex I subunit 4 family. (525 aa)
pexPex protein; ORF_ID:alr3979. (115 aa)
isiAPhotosystem II chlorophyll a-binding protein; Functions as an antenna for photosystem I (PSI) under iron- limiting conditions, when phycobilisomes disappear. In the (PSI)3(Isi3)18 complex most of the harvested energy is probably used by PSI; in other PSI-containing supercomplexes a large part of the energy will probably not be used for light harvesting, but rather is dissipated to protect the organism from light damage. Belongs to the PsbB/PsbC family. IsiA/Pcb subfamily. (344 aa)
hrcAHeat-inducible transcriptional repressor; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (365 aa)
all4107Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism (By similarity). (202 aa)
cytACytochrome c6; Functions as an electron carrier between membrane-bound cytochrome b6-f and photosystem I in oxygenic photosynthesis. (111 aa)
all4272Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (376 aa)
all4289Photosystem I assembly protein Ycf4; Seems to be required for the assembly of the photosystem I complex; Belongs to the Ycf4 family. (198 aa)
psbDPhotosystem II protein D2; Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors. D2 is needed for assembly of a stable PSII complex. (351 aa)
dnaK-5DnaK-type molecular chaperone; ORF_ID:all4477; dnaK gene product; Belongs to the heat shock protein 70 family. (712 aa)
psbD-2Photosystem II protein D2; ORF_ID:alr4548. (351 aa)
alr4559WD-40 repeat-protein; ORF_ID:alr4559. (786 aa)
secAPreprotein translocase SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. (930 aa)
clpB-4Endopeptidase Clp ATP-binding chain B; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/ClpB [...] (835 aa)
pmbAPmbA protein; ORF_ID:all5218; putative modulator of DNA gyrase; PmbA. (446 aa)
glcDGlycolate oxidase subunit; ORF_ID:alr5269; glcD gene product. (430 aa)
alr5287GTP cyclohydrolase I; ORF_ID:alr5287. (235 aa)
Your Current Organism:
Nostoc sp. PCC7120
NCBI taxonomy Id: 103690
Other names: Anabaena sp. (ATCC 27893), Anabaena sp. (PCC 7120), Anabaena sp. DCC D0672, Anabaena sp. PCC 7120, Anabaena sp. SAG 25.82, Anabaena sp. UTEX B 2576, Anabaena variabilis UTCC 387, N. sp. PCC 7120, Nostoc muscorum ISU, Nostoc sp. AKM24, Nostoc sp. ATCC 27347, Nostoc sp. ATCC 72893, Nostoc sp. DSM 107007, Nostoc sp. Ind43, Nostoc sp. PCC 7120, Nostoc sp. SAG 25.82
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