STRINGSTRING
hetF hetF psbA psbA hrcA hrcA ntcA ntcA all5184 all5184 all5265 all5265 hetN hetN hepA hepA fdxB fdxB patB patB pilT pilT pilT-2 pilT-2 nlpD nlpD hetR hetR glnA glnA patS patS dnaA dnaA alr0094 alr0094 alr0101 alr0101 alr0487 alr0487 patA patA cheW cheW alr1113 alr1113 alr1128 alr1128 nifW nifW nifB nifB rbcS rbcS all1682 all1682
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hetFHeterocyst differentiation protein; ORF_ID:alr3546; hetF gene product. (779 aa)
psbAPhotosystem II protein D1; Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors. (360 aa)
hrcAHeat-inducible transcriptional repressor; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (365 aa)
ntcANitrogen-responsive regulatory protein; Required for full expression of proteins subject to ammonium repression. Transcriptional activator of genes subject to nitrogen control. (223 aa)
all5184Mg2+ transport protein; Acts as a magnesium transporter. (466 aa)
all5265DNA gyrase B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (645 aa)
hetNKetoacyl reductase; May be involved in repressing heterocyst differentiation and may be essential for preventing all vegetative cells from differentiating. (287 aa)
hepAATP-binding protein; Acts early in the process of morphological differentiation of heterocysts. (607 aa)
fdxBFerredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (97 aa)
patBTranscriptional regulator; ORF_ID:all2512; patB gene product. (529 aa)
pilTTwitching motility protein; ORF_ID:all2443; pilT gene product. (372 aa)
pilT-2Twitching motility protein; ORF_ID:all3329; pilT gene product. (432 aa)
nlpDLipoprotein; ORF_ID:asl2362; nlpD gene product. (77 aa)
hetRHeterocyst differentiation protein; Controls heterocyst differentiation. Has both a protease and a DNA-binding activity. Binds the promoter regions of hetR, hepA and patS. (299 aa)
glnAGlutamate--ammonia ligase; Involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. (474 aa)
patSHeterocyst-inhibiting signaling peptide; Inhibits heterocyst differentiation. Seems to control heterocyst pattern formation through intercellular signaling mechanisms. In Anabaena filaments every 10th vegetative cell terminally differentiates into a heterocyst specialized for nitrogen fixation. Seems to inhibit the formation of adjacent heterocysts. Inhibits the DNA-binding of HetR. (17 aa)
dnaAChromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (459 aa)
alr0094Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (292 aa)
alr0101ORF_ID:alr0101; unknown protein. (258 aa)
alr0487Cell division protein SepF; Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA. (198 aa)
patATwo-component response regulator, heterocyst pattern formation protein; Controls heterocyst pattern formation. Required for the differentiation of intercalary heterocysts but not for terminal heterocysts. (379 aa)
cheWChemotaxis protein; ORF_ID:all0928; cheW gene product. (176 aa)
alr1113ParA family protein; ORF_ID:alr1113. (460 aa)
alr1128Chromosome segregation protein; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1208 aa)
nifWNitrogen fixation protein; May protect the nitrogenase Fe-Mo protein from oxidative damage; Belongs to the NifW family. (105 aa)
nifBNitrogen fixation protein; Involved in the biosynthesis of the iron-molybdenum cofactor (FeMo-co or M-cluster) found in the dinitrogenase enzyme of the nitrogenase complex in nitrogen-fixing microorganisms. NifB catalyzes the crucial step of radical SAM-dependent carbide insertion that occurs concomitant with the insertion of a 9th sulfur and the rearrangement/coupling of two [4Fe-4S] clusters into a [8Fe-9S-C] cluster, the precursor to the M-cluster. (475 aa)
rbcSRibulose 1,5-bisphosphate carboxylase/oxygenase small subunit; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site (By similarity); Belongs to the RuBisCO small chain family. (109 aa)
all1682Magnesium transporter MgtE; Acts as a magnesium transporter. (465 aa)
Your Current Organism:
Nostoc sp. PCC7120
NCBI taxonomy Id: 103690
Other names: Anabaena sp. (ATCC 27893), Anabaena sp. (PCC 7120), Anabaena sp. DCC D0672, Anabaena sp. PCC 7120, Anabaena sp. SAG 25.82, Anabaena sp. UTEX B 2576, Anabaena variabilis UTCC 387, N. sp. PCC 7120, Nostoc muscorum ISU, Nostoc sp. AKM24, Nostoc sp. ATCC 27347, Nostoc sp. ATCC 72893, Nostoc sp. DSM 107007, Nostoc sp. Ind43, Nostoc sp. PCC 7120, Nostoc sp. SAG 25.82
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