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dnaK-2 dnaK-2 patA patA all0635 all0635 cheW cheW coxC coxC dnaK dnaK sir sir petG petG dnaJ dnaJ clpB clpB clpB-2 clpB-2 grpE grpE dnaK-3 dnaK-3 dnaJ-2 dnaJ-2 coxC-2 coxC-2 coxC-3 coxC-3 dnaK-4 dnaK-4 dnaJ-3 dnaJ-3 dnaJ-4 dnaJ-4 clpB-3 clpB-3 alr3146 alr3146 alr3147 alr3147 alr3397 alr3397 groES groES groEL-2 groEL-2 all4376 all4376 dnaK-5 dnaK-5 dnaJ-5 dnaJ-5 agp agp clpB-4 clpB-4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dnaK-2DnaK-type molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. (633 aa)
patATwo-component response regulator, heterocyst pattern formation protein; Controls heterocyst pattern formation. Required for the differentiation of intercalary heterocysts but not for terminal heterocysts. (379 aa)
all0635Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (821 aa)
cheWChemotaxis protein; ORF_ID:all0928; cheW gene product. (176 aa)
coxCCytochrome c oxidase subunit III; ORF_ID:alr0952. (207 aa)
dnaKDnaK-type molecular chaperone; ORF_ID:alr1264; dnaK gene product; Belongs to the heat shock protein 70 family. (532 aa)
sirFerredoxin-sulfite reductase; ORF_ID:alr1348; sir gene product; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (650 aa)
petGCytochrome b6-f complex subunit 5; Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions. PetG is required for either the stability or assembly of the cytochrome b6-f complex. (37 aa)
dnaJChaperone protein; ORF_ID:all1488; dnaJ gene product. (315 aa)
clpBEndopeptidase Clp ATP-binding chain; ORF_ID:alr1963; Belongs to the ClpA/ClpB family. (814 aa)
clpB-2Endopeptidase Clp ATP-binding chain; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/ClpB family. (880 aa)
grpEHeat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depen [...] (248 aa)
dnaK-3DnaK-type molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. (653 aa)
dnaJ-2DnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] (376 aa)
coxC-2Cytochrome c oxidase subunit III; ORF_ID:alr2516. (197 aa)
coxC-3Cytochrome c oxidase subunit III; ORF_ID:alr2734. (200 aa)
dnaK-4DnaK-type molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. (688 aa)
dnaJ-3DnaJ protein; ORF_ID:alr2991. (333 aa)
dnaJ-4DnaJ protein; ORF_ID:alr2993. (167 aa)
clpB-3Endopeptidase Clp ATP-binding chain; ORF_ID:alr2999; Belongs to the ClpA/ClpB family. (839 aa)
alr3146Phosphoenolpyruvate synthase; ORF_ID:alr3146. (643 aa)
alr3147Phosphoenolpyruvate synthase; ORF_ID:alr3147. (163 aa)
alr3397Phosphoenolpyruvate synthase; ORF_ID:alr3397. (775 aa)
groESChaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (103 aa)
groEL-2Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (544 aa)
all4376Sucrose-phosphate synthase; ORF_ID:all4376; probable glycosyl transferase. (422 aa)
dnaK-5DnaK-type molecular chaperone; ORF_ID:all4477; dnaK gene product; Belongs to the heat shock protein 70 family. (712 aa)
dnaJ-5Chaperone DnaJ protein; ORF_ID:all4643. (333 aa)
agpGlucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. (429 aa)
clpB-4Endopeptidase Clp ATP-binding chain B; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/ClpB [...] (835 aa)
Your Current Organism:
Nostoc sp. PCC7120
NCBI taxonomy Id: 103690
Other names: Anabaena sp. (ATCC 27893), Anabaena sp. (PCC 7120), Anabaena sp. DCC D0672, Anabaena sp. PCC 7120, Anabaena sp. SAG 25.82, Anabaena sp. UTEX B 2576, Anabaena variabilis UTCC 387, N. sp. PCC 7120, Nostoc muscorum ISU, Nostoc sp. AKM24, Nostoc sp. ATCC 27347, Nostoc sp. ATCC 72893, Nostoc sp. DSM 107007, Nostoc sp. Ind43, Nostoc sp. PCC 7120, Nostoc sp. SAG 25.82
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