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alr0030 alr0030 all0067 all0067 chlP chlP chlI chlI chlD chlD hemD hemD alr0379 alr0379 all0453 all0453 all0455 all0455 alr0520 alr0520 hemF hemF all0948 all0948 all0949 all0949 hemA hemA all1357 all1357 alr1358 alr1358 all1601 all1601 CobN CobN por por all1780 all1780 alr1878 alr1878 all1880 all1880 all1897 all1897 cobD cobD alr2377 alr2377 all2391 all2391 all2544 all2544 all2847 all2847 alr3125 alr3125 alr3126 alr3126 alr3162 alr3162 all3174 all3174 alr3201 alr3201 gltX gltX alr3265 alr3265 alr3300 alr3300 chlB chlB alr3450 alr3450 alr3707 alr3707 all3722 all3722 alr3751 alr3751 all3802 all3802 all3876 all3876 hemE hemE alr3934 alr3934 all3940 all3940 bvdR bvdR chlH chlH alr4380 alr4380 chlG chlG alr4616 alr4616 all4698 all4698 all4725 all4725 chlH-2 chlH-2 chlN chlN chlL chlL alr5217 alr5217
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
alr0030ORF_ID:alr0030; similar to Mg-protoporphyrin IX monomethyl ester oxidative cyclase. (590 aa)
all0067cob(I)alamin adenosyltransferase; ORF_ID:all0067. (178 aa)
chlPGeranylgeranyl hydrogenase; ORF_ID:alr0128; chlP gene product. (406 aa)
chlIProtoporphyrin IX magnesium chelatase chain; Involved in chlorophyll biosynthesis; introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX. (374 aa)
chlDMg chelatase subunit; Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX. (678 aa)
hemDuroporphyrinogen-III synthase; ORF_ID:all0287; hemD gene product. (276 aa)
alr0379Adenosylcobinamide-GDP ribazoletransferase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (252 aa)
all0453Cobalamin biosynthesis precorrin-3 methylase; ORF_ID:all0453. (574 aa)
all0455Cobalamin biosynthesis precorrin-2 methyltransferase; ORF_ID:all0455; Belongs to the precorrin methyltransferase family. (234 aa)
alr0520uroporphyrin-III C-methyltransferase; ORF_ID:alr0520; Belongs to the precorrin methyltransferase family. (260 aa)
hemFCoproporphyrinogen III oxidase; Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity). (317 aa)
all0948Heme O synthase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (318 aa)
all0949ORF_ID:all0949; hypothetical protein. (333 aa)
hemAGlutamyl tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (428 aa)
all1357Coproporphyrinogen III oxidase; Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity). (347 aa)
alr1358Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase 1; Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME); Belongs to the AcsF family. (351 aa)
all1601ORF_ID:all1601; hypothetical protein. (397 aa)
CobNCobalamin biosynthetic protein; ORF_ID:alr1689; cobN gene product. (1302 aa)
porProtochlorophyllide oxido-reductase; Phototransformation of protochlorophyllide (Pchlide) to chlorophyllide (Chlide). (329 aa)
all1780Precorrin-6x reductase; ORF_ID:all1780. (245 aa)
alr1878Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (336 aa)
all1880Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase 2; Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME); Belongs to the AcsF family. (358 aa)
all1897Heme oxygenase; Catalyzes the opening of the heme ring with the release of iron. Key enzyme in the synthesis of the chromophoric part of the photosynthetic antennae (By similarity). Upon overexpression in E.coli with PCB:ferredoxin oxidoreductase, CpeS and either CpcB or PecB permits synthesis of phycocyanin-coupled CpcB or PecB. (238 aa)
cobDCobalamin biosynthetic protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (320 aa)
alr2377Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (493 aa)
all2391ORF_ID:all2391; hypothetical protein. (378 aa)
all2544Precorrin isomerase; ORF_ID:all2544. (206 aa)
all2847Cobalamin biosynthesis protein D; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (370 aa)
alr3125Heme oxygenase; ORF_ID:alr3125. (237 aa)
alr3126Oxygen independent coprophorphyrinogen III oxidase; ORF_ID:alr3126; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (460 aa)
alr3162Transcriptional regulator; ORF_ID:alr3162. (368 aa)
all3174Cobinamide kinase; ORF_ID:all3174. (181 aa)
alr3201Mg-protoporphyrin IX methyl transferase; ORF_ID:alr3201. (228 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (480 aa)
alr3265Glutamate-1-semialdehyde 2,1-aminomutase; ORF_ID:alr3265; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (411 aa)
alr3300Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase 3; Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME); Belongs to the AcsF family. (358 aa)
chlBProtochlorophyllide reductase ChlB subunit; Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (ChlN-ChlB) is the catalytic component of the complex. (508 aa)
alr3450Uroporphyrinogen III methylase; ORF_ID:alr3450; Belongs to the precorrin methyltransferase family. (517 aa)
alr3707Phycocyanobilin:ferredoxin oxidoreductase; Catalyzes the four-electron reduction of biliverdin IX-alpha (2-electron reduction at both the A and D rings); the reaction proceeds via an isolatable 2-electron intermediate, 181,182-dihydrobiliverdin. Upon overexpression in E.coli with PCB:ferredoxin oxidoreductase, CpeS and either CpcB or PecB permits synthesis of phycocyanin-coupled CpcB or PecB; Belongs to the HY2 family. (245 aa)
all3722Precorrin-6y-dependent methyltransferase; ORF_ID:all3722. (403 aa)
alr3751Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (388 aa)
all3802cob(I)alamin adenosyltransferase; ORF_ID:all3802. (230 aa)
all3876Precorrin decarbocylase; ORF_ID:all3876. (231 aa)
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (350 aa)
alr3934Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (514 aa)
all3940ORF_ID:all3940; hypothetical protein. (144 aa)
bvdRBiliverdin reductase; ORF_ID:alr4149. (322 aa)
chlHProtoporphyrin IX magnesium chelatase; ORF_ID:all4365; chlH gene product. (1328 aa)
alr4380Delta-aminolevulinic acid dehydratase; ORF_ID:alr4380; Belongs to the ALAD family. (326 aa)
chlGChlorophyll synthase 33 kD subunit; ORF_ID:all4480. (344 aa)
alr4616ORF_ID:alr4616; similar to ferrochelatase; Belongs to the ferrochelatase family. (349 aa)
all4698Precorrin-3 methylase; ORF_ID:all4698; Belongs to the precorrin methyltransferase family. (261 aa)
all4725Delta-aminolevulinic acid dehydratase; ORF_ID:all4725; Belongs to the ALAD family. (336 aa)
chlH-2Protoporphyrin IX magnesium chelatase; ORF_ID:alr4733. (1228 aa)
chlNProtochlorophillide reductase subunit; Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (ChlN-ChlB) is the catalytic component of the complex. (467 aa)
chlLProtochlorophyllide reductase iron-sulfur ATP-binding protein; Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP. (288 aa)
alr5217ORF_ID:alr5217; hypothetical protein. (180 aa)
Your Current Organism:
Nostoc sp. PCC7120
NCBI taxonomy Id: 103690
Other names: Anabaena sp. (ATCC 27893), Anabaena sp. (PCC 7120), Anabaena sp. DCC D0672, Anabaena sp. PCC 7120, Anabaena sp. SAG 25.82, Anabaena sp. UTEX B 2576, Anabaena variabilis UTCC 387, N. sp. PCC 7120, Nostoc muscorum ISU, Nostoc sp. AKM24, Nostoc sp. ATCC 27347, Nostoc sp. ATCC 72893, Nostoc sp. DSM 107007, Nostoc sp. Ind43, Nostoc sp. PCC 7120, Nostoc sp. SAG 25.82
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