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all0122 all0122 alr0212 alr0212 gltA gltA all0262 all0262 all0635 all0635 alr0782 alr0782 all0888 all0888 accC accC all0945 all0945 alr1004 alr1004 alr1041 alr1041 alr1050 alr1050 gap3 gap3 all1169 all1169 all1267 all1267 all1371 all1371 alr1404 alr1404 rbcL rbcL rbcS rbcS devB devB all1683 all1683 icd icd alr1890 alr1890 nifJ nifJ alr1913 alr1913 alr1982 alr1982 alr2350 alr2350 accD accD all2509 all2509 all2521 all2521 ackA ackA tal tal all2564 all2564 gap1 gap1 alr2708 alr2708 nifJ-2 nifJ-2 aroE aroE all2810 all2810 alr2873 alr2873 all2970 all2970 alr2973 alr2973 alr3086 alr3086 alr3146 alr3146 alr3147 alr3147 alr3338 alr3338 all3341 all3341 alr3344 alr3344 alr3397 alr3397 all3538 all3538 alr3606 alr3606 alr3724 alr3724 all3735 all3735 all3836 all3836 all3913 all3913 all3914 all3914 alr3937 alr3937 all4008 all4008 zwf zwf tal-2 tal-2 fbp fbp all4037 all4037 all4052 all4052 prk prk all4131 all4131 all4182 all4182 alr4232 alr4232 all4237 all4237 all4257 all4257 alr4322 alr4322 alr4385 alr4385 alr4416 alr4416 alr4552 alr4552 fda fda alr4596 alr4596 all4607 all4607 all4608 all4608 all4609 all4609 alr4670 alr4670 alr4745 alr4745 all4771 all4771 alr4806 alr4806 pepC pepC all5002 all5002 accB accB gap2 gap2 alr5275 alr5275 accA accA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
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all0122Pyruvate dehydrogenase E1 beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (327 aa)
alr0212Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (299 aa)
gltACitrate synthase; ORF_ID:alr0222; gltA gene product; Belongs to the citrate synthase family. (378 aa)
all0262Threonine dehydratase; ORF_ID:all0262. (257 aa)
all0635Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (821 aa)
alr0782Ribulose-phosphate 3-epimerase; ORF_ID:alr0782; Belongs to the ribulose-phosphate 3-epimerase family. (235 aa)
all0888Ribose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (236 aa)
accCBiotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa)
all0945Succinate dehydrogenase iron-sulfur protein subunit; ORF_ID:all0945; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (333 aa)
alr1004Alanine--glyoxylate aminotransferase; ORF_ID:alr1004. (381 aa)
alr1041Fructose-1,6-bisphosphatase; Catalyzes the hydrolysis of fructose 1,6-bisphosphate (Fru 1,6-P2) and sedoheptulose 1,7-bisphosphate (Sed 1,7-P2) to fructose 6- phosphate and sedoheptulose 7-phosphate, respectively; Belongs to the FBPase class 2 family. (345 aa)
alr1050Glucose-6-phosphate isomerase; ORF_ID:alr1050. (528 aa)
gap3Glyceraldehyde-3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-phosphate dehydrogenase [...] (337 aa)
all1169Cysteine synthase; ORF_ID:all1169. (365 aa)
all1267Aconitate hydratase; ORF_ID:all1267; Belongs to the aconitase/IPM isomerase family. (876 aa)
all1371Polyphosphate glucokinase; ORF_ID:all1371. (239 aa)
alr1404Serine acetyltransferase; ORF_ID:alr1404. (250 aa)
rbcLRibulose-1,5-bisphosphate carboxylase/oxygenase large subunit; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site. Belongs to the RuBisCO large chain family. Type I subfamily. (476 aa)
rbcSRibulose 1,5-bisphosphate carboxylase/oxygenase small subunit; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site (By similarity); Belongs to the RuBisCO small chain family. (109 aa)
devBglucose-6-P-dehydrogenase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily. (240 aa)
all1683Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (392 aa)
icdIsocitrate dehydrogenase; ORF_ID:alr1827; icd gene product. (473 aa)
alr1890Phosphoglycerate dehydrogenase; ORF_ID:alr1890; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (526 aa)
nifJPyruvate flavodoxin dehydrogenase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin. (1187 aa)
alr19136-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (357 aa)
alr1982ORF_ID:alr1982; putative sugar kinase. (317 aa)
alr2350Phosphoribulokinase; ORF_ID:alr2350. (313 aa)
accDacetyl-CoA carboxylase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (316 aa)
all2509ORF_ID:all2509; similar to phosphoenolpyruvate synthase. (963 aa)
all2521Cysteine synthase; ORF_ID:all2521; Belongs to the cysteine synthase/cystathionine beta- synthase family. (319 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (405 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (332 aa)
all2564Pyruvate kinase; ORF_ID:all2564; Belongs to the pyruvate kinase family. (476 aa)
gap1Glyceraldehyde-3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. (343 aa)
alr2708Pyruvate dehydrogenase E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (344 aa)
nifJ-2Pyruvate-flavodoxin dehydrogenase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin, which reduces nitrogenase. (1199 aa)
aroES-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (282 aa)
all2810Glutathione dependent formaldehyde dehydrogenase; ORF_ID:all2810; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (369 aa)
alr2873ORF_ID:alr2873; hypothetical protein. (335 aa)
all2970Succinate dehydrogenase flavoprotein; ORF_ID:all2970. (575 aa)
alr2973Glucokinase; ORF_ID:alr2973; Belongs to the bacterial glucokinase family. (342 aa)
alr3086Gluconokinase; ORF_ID:alr3086. (160 aa)
alr3146Phosphoenolpyruvate synthase; ORF_ID:alr3146. (643 aa)
alr3147Phosphoenolpyruvate synthase; ORF_ID:alr3147. (163 aa)
alr3338Phosphoglycerate mutase; ORF_ID:alr3338; Belongs to the phosphoglycerate mutase family. (449 aa)
all3341Heterodisulfide reductase, subunit B; ORF_ID:all3341. (301 aa)
alr3344Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate; Belongs to the transketolase family. (670 aa)
alr3397Phosphoenolpyruvate synthase; ORF_ID:alr3397. (775 aa)
all3538Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa)
alr3606Dihydrolipoamide S-acetyltransferase; ORF_ID:alr3606. (430 aa)
alr3724Aspartate ammonia-lyase; ORF_ID:alr3724. (471 aa)
all3735Fructose-bisphosphate aldolase class I; ORF_ID:all3735. (360 aa)
all3836Glucose 1-dehydrogenase; ORF_ID:all3836. (269 aa)
all3913succinyl-CoA synthetase alpha chain; ORF_ID:all3913. (293 aa)
all3914succinyl-CoA synthetase beta chain; ORF_ID:all3914. (408 aa)
alr3937Mercuric reductase; ORF_ID:alr3937. (489 aa)
all4008Pyruvate kinase; ORF_ID:all4008; Belongs to the pyruvate kinase family. (589 aa)
zwfGlucose 6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (509 aa)
tal-2Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (381 aa)
fbpFructose 1,6-bisphosphatase; ORF_ID:all4021. (349 aa)
all4037Serine acetyltransferase; ORF_ID:all4037. (253 aa)
all4052Transketolase; ORF_ID:all4052. (633 aa)
prkPhosphoribulokinase; ORF_ID:alr4123. (334 aa)
all4131Phosphoglycerate kinase; ORF_ID:all4131. (400 aa)
all41822,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (533 aa)
alr4232Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (503 aa)
all4237ORF_ID:all4237; hypothetical protein. (100 aa)
all4257Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (524 aa)
alr4322Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (284 aa)
alr4385Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (241 aa)
alr4416Cystathionine beta-synthase; ORF_ID:alr4416. (324 aa)
alr4552Cysteine synthase; ORF_ID:alr4552; Belongs to the cysteine synthase/cystathionine beta- synthase family. (320 aa)
fdaFructose-1,6-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (359 aa)
alr4596Malic enzyme; ORF_ID:alr4596. (463 aa)
all4607Glycine cleavage system protein P; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (983 aa)
all4608Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (130 aa)
all4609Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (376 aa)
alr4670Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (330 aa)
alr4745Dihydrolipoamide dehydrogenase; ORF_ID:alr4745. (475 aa)
all4771KHG-KDPG bifunctional aldolase; ORF_ID:all4771. (210 aa)
alr4806Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (427 aa)
pepCPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (982 aa)
all5002Sugar kinase; ORF_ID:all5002. (311 aa)
accBBiotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (182 aa)
gap2Glyceraldehyde-3-phosphate dehydrogenase; Gap2 has a major role in carbon fixation as a component of the Calvin cycle. Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NADP. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NADP to NADPH. The reduced NADPH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic p [...] (337 aa)
alr52756-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (476 aa)
accAacetyl-CoA carboxylase alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (326 aa)
Your Current Organism:
Nostoc sp. PCC7120
NCBI taxonomy Id: 103690
Other names: Anabaena sp. (ATCC 27893), Anabaena sp. (PCC 7120), Anabaena sp. DCC D0672, Anabaena sp. PCC 7120, Anabaena sp. SAG 25.82, Anabaena sp. UTEX B 2576, Anabaena variabilis UTCC 387, N. sp. PCC 7120, Nostoc muscorum ISU, Nostoc sp. AKM24, Nostoc sp. ATCC 27347, Nostoc sp. ATCC 72893, Nostoc sp. DSM 107007, Nostoc sp. Ind43, Nostoc sp. PCC 7120, Nostoc sp. SAG 25.82
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