STRINGSTRING
apt apt pyrR pyrR pyrB pyrB pyrC pyrC MCOL_V219386 MCOL_V219386 carA carA carB carB pyrF pyrF gmk gmk gcvH gcvH gcvP gcvP MCOL_V209400 MCOL_V209400 pyrD pyrD gcvT gcvT glyA glyA MCOL_V225082 MCOL_V225082 purH purH purN purN purM purM purF purF purL purL purQ purQ purS purS purC purC MCOL_V213560 MCOL_V213560 purD purD MCOL_V201615 MCOL_V201615 MCOL_V201600 MCOL_V201600 pyrE pyrE purA purA purT purT guaB guaB MCOL_V216174 MCOL_V216174 guaA guaA folD folD purK purK GCA_002105755_04980 GCA_002105755_04980 purE purE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
aptUnannotated protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (180 aa)
pyrRUnannotated protein; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (194 aa)
pyrBUnannotated protein; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (322 aa)
pyrCUnannotated protein; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (430 aa)
MCOL_V219386Unannotated protein. (167 aa)
carAUnannotated protein; Belongs to the CarA family. (373 aa)
carBUnannotated protein; Belongs to the CarB family. (1116 aa)
pyrFUnannotated protein; Belongs to the OMP decarboxylase family. Type 2 subfamily. (274 aa)
gmkUnannotated protein; Essential for recycling GMP and indirectly, cGMP. (201 aa)
gcvHUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (132 aa)
gcvPUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (942 aa)
MCOL_V209400Unannotated protein. (478 aa)
pyrDUnannotated protein; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (368 aa)
gcvTUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. (371 aa)
glyAUnannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa)
MCOL_V225082Unannotated protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (199 aa)
purHUnannotated protein. (527 aa)
purNUnannotated protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (215 aa)
purMUnannotated protein. (364 aa)
purFUnannotated protein; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (508 aa)
purLUnannotated protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the amm [...] (765 aa)
purQUnannotated protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the amm [...] (224 aa)
purSUnannotated protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the amm [...] (79 aa)
purCUnannotated protein; Belongs to the SAICAR synthetase family. (296 aa)
MCOL_V213560Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (472 aa)
purDUnannotated protein; Belongs to the GARS family. (422 aa)
MCOL_V201615Unannotated protein; Belongs to the globin family. (393 aa)
MCOL_V201600Unannotated protein. (292 aa)
pyrEUnannotated protein; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (179 aa)
purAUnannotated protein; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)
purTUnannotated protein; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate. Belongs to the PurK/PurT family. (418 aa)
guaBUnannotated protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (531 aa)
MCOL_V216174Unannotated protein. (375 aa)
guaAUnannotated protein; Catalyzes the synthesis of GMP from XMP. (530 aa)
folDUnannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (281 aa)
purKUnannotated protein; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (405 aa)
GCA_002105755_04980Unannotated protein. (88 aa)
purEUnannotated protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (95 aa)
Your Current Organism:
Mycobacterium colombiense
NCBI taxonomy Id: 1041522
Other names: M. colombiense CECT 3035, Mycobacterium colombiense 10B, Mycobacterium colombiense CECT 3035, Mycobacterium colombiense CIP 108962, Mycobacterium colombiense DSM 45105, Mycobacterium colombiense str. CECT 3035, Mycobacterium colombiense strain CECT 3035
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