STRINGSTRING
hpf hpf rpsI rpsI rplM rplM rpsK rpsK rplO rplO rpmD rpmD rpsE rpsE rplR rplR rpsH rpsH rpsZ rpsZ rplE rplE rplX rplX rplN rplN rpsQ rpsQ rpmC rpmC rpsC rpsC rplB rplB rplW rplW rplC rplC rpsJ rpsJ rpsG rpsG rplL rplL rplJ rplJ rpmG-2 rpmG-2 MCOL_V201185 MCOL_V201185 rpmE2 rpmE2 rpmB-2 rpmB-2 rpmG rpmG rpsN rpsN rpsR-2 rpsR-2 rpsF rpsF rpsR rpsR MCOL_V212100 MCOL_V212100 rpmF rpmF rpmE rpmE rplU rplU obgE obgE rplT rplT rpmI rpmI rpsA rpsA rpsO rpsO rpsB rpsB rpsP rpsP rpmB rpmB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hpfUnannotated protein; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (227 aa)
rpsIUnannotated protein; Belongs to the universal ribosomal protein uS9 family. (179 aa)
rplMUnannotated protein; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (147 aa)
rpsKUnannotated protein; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (138 aa)
rplOUnannotated protein; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (147 aa)
rpmDUnannotated protein. (72 aa)
rpsEUnannotated protein; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (227 aa)
rplRUnannotated protein; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (135 aa)
rpsHUnannotated protein; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
rpsZUnannotated protein; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
rplEUnannotated protein; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (187 aa)
rplXUnannotated protein; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (105 aa)
rplNUnannotated protein; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rpsQUnannotated protein; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (118 aa)
rpmCUnannotated protein; Belongs to the universal ribosomal protein uL29 family. (77 aa)
rpsCUnannotated protein; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (278 aa)
rplBUnannotated protein; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (280 aa)
rplWUnannotated protein; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (100 aa)
rplCUnannotated protein; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (217 aa)
rpsJUnannotated protein; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (101 aa)
rpsGUnannotated protein; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rplLUnannotated protein; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (131 aa)
rplJUnannotated protein; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (202 aa)
rpmG-2Unannotated protein; Belongs to the bacterial ribosomal protein bL33 family. (55 aa)
MCOL_V201185Unannotated protein; Belongs to the AAA ATPase family. (731 aa)
rpmE2Unannotated protein; Belongs to the bacterial ribosomal protein bL31 family. (84 aa)
rpmB-2Unannotated protein; Belongs to the bacterial ribosomal protein bL28 family. (78 aa)
rpmGUnannotated protein; Belongs to the bacterial ribosomal protein bL33 family. (54 aa)
rpsNUnannotated protein; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa)
rpsR-2Unannotated protein; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (88 aa)
rpsFUnannotated protein; Binds together with S18 to 16S ribosomal RNA. (96 aa)
rpsRUnannotated protein; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (84 aa)
MCOL_V212100Unannotated protein. (482 aa)
rpmFUnannotated protein; Belongs to the bacterial ribosomal protein bL32 family. (57 aa)
rpmEUnannotated protein; Binds the 23S rRNA. (76 aa)
rplUUnannotated protein; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa)
obgEUnannotated protein; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (499 aa)
rplTUnannotated protein; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (131 aa)
rpmIUnannotated protein; Belongs to the bacterial ribosomal protein bL35 family. (64 aa)
rpsAUnannotated protein. (478 aa)
rpsOUnannotated protein; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa)
rpsBUnannotated protein; Belongs to the universal ribosomal protein uS2 family. (277 aa)
rpsPUnannotated protein; Belongs to the bacterial ribosomal protein bS16 family. (175 aa)
rpmBUnannotated protein; Belongs to the bacterial ribosomal protein bL28 family. (64 aa)
Your Current Organism:
Mycobacterium colombiense
NCBI taxonomy Id: 1041522
Other names: M. colombiense CECT 3035, Mycobacterium colombiense 10B, Mycobacterium colombiense CECT 3035, Mycobacterium colombiense CIP 108962, Mycobacterium colombiense DSM 45105, Mycobacterium colombiense str. CECT 3035, Mycobacterium colombiense strain CECT 3035
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