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| | purM | IMG term: phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1). (360 aa) |
| | serA | IMG term: D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (526 aa) |
| | prsA-1 | Ribose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family. (296 aa) |
| | cbiX | Putative sirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. (133 aa) |
| | murD | UDP-N-acetylmuramyl pentapeptide synthase. (416 aa) |
| | Mtc_0063 | Putative methanogenesis marker 13 metalloprotein; Nitrogenase-related. (365 aa) |
| | nifH-1 | IMG term: Mo-nitrogenase iron protein subunit NifH (EC 1.18.6.1). (262 aa) |
| | cbiA-1 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (463 aa) |
| | apbA | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (297 aa) |
| | eno-1 | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (422 aa) |
| | aroD | 3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (218 aa) |
| | ilvE | Branched-chain amino acid aminotransferase, group I; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (292 aa) |
| | gpi | IMG term: glucose-6-phosphate isomerase (EC 5.3.1.9). (250 aa) |
| | Mtc_0172 | Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis. (231 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (231 aa) |
| | Mtc_0185 | dTDP-glucose pyrophosphorylase. (332 aa) |
| | rfbB-1 | IMG term: dTDP-glucose 4,6-dehydratase (EC 4.2.1.46). (318 aa) |
| | rfbD-1 | IMG term: dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133). (280 aa) |
| | rfbA | Glucose-1-phosphate thymidylylransferase, long form; IMG term: Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24). (357 aa) |
| | rfbB-2 | IMG term: dTDP-glucose 4,6-dehydratase (EC 4.2.1.46). (324 aa) |
| | rfbC | dTDP-4-dehydrorhamnose 3,5-epimerase and related enzyme. (196 aa) |
| | asnB-1 | Asparagine synthase (glutamine-hydrolyzing). (593 aa) |
| | ilvB | IMG term: acetolactate synthase, large subunit (EC 2.2.1.6). (566 aa) |
| | ilvN | IMG term: acetolactate synthase, small subunit (EC 2.2.1.6). (171 aa) |
| | leuA | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (520 aa) |
| | Mtc_0221 | proFAR isomerase (HisA)-like protein; Belongs to the HisA/HisF family. (229 aa) |
| | Mtc_0261 | Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (285 aa) |
| | hmgA-1 | hydroxymethylglutaryl-CoA reductase, degradative; Belongs to the HMG-CoA reductase family. (430 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase, type II; IMG term: glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12). (352 aa) |
| | hemD | IMG term: uroporphyrinogen-III synthase (EC 4.2.1.75). (252 aa) |
| | cobA | IMG term: uroporphyrinogen-III C-methyltransferase (EC 2.1.1.107). (246 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (304 aa) |
| | hemL | Glutamate-1-semialdehyde-2,1-aminomutase; IMG term: glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (424 aa) |
| | hemB | Delta-aminolevulinic acid dehydratase; IMG term: porphobilinogen synthase (EC 4.2.1.24); Belongs to the ALAD family. (322 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (416 aa) |
| | cysG | Siroheme synthase, N-terminal domain protein. (212 aa) |
| | argE | IMG term: acetylornithine deacetylase (EC 3.5.1.16). (378 aa) |
| | aroK | IMG term: shikimate kinase (EC 2.7.1.71). (280 aa) |
| | aroQ | IMG term: chorismate mutase (EC 5.4.99.5). (94 aa) |
| | tyrA | IMG term: prephenate dehydrogenase (EC 1.3.1.12). (285 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (268 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase (non-peptidoglycan organisms); IMG term: aspartate semialdehyde dehydrogenase (EC 1.2.1.11). (344 aa) |
| | trpC | Indole-3-glycerol phosphate synthase. (249 aa) |
| | trpE | Anthranilate synthase component I; Non-proteobacterial lineages. (496 aa) |
| | trpG | Anthranilate synthase component II; IMG term: anthranilate phosphoribosyltransferase (EC 2.4.2.18); IMG term: anthranilate synthase, component II (EC 4.1.3.27). (190 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (348 aa) |
| | trpF | IMG term: phosphoribosylanthranilate isomerase (EC 5.3.1.24); Belongs to the TrpF family. (214 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (392 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (238 aa) |
| | tpi | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (219 aa) |
| | fbaB | DhnA-type fructose-1,6-bisphosphate aldolase and related enzyme. (267 aa) |
| | purT | Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase). (426 aa) |
| | hmgA-2 | 3-hydroxy-3-methylglutaryl Coenzyme A reductase, hydroxymethylglutaryl-CoA reductase (NADP); Belongs to the HMG-CoA reductase family. (405 aa) |
| | dapA-1 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (314 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (255 aa) |
| | uppS-1 | Undecaprenyl pyrophosphate synthase. (213 aa) |
| | argH | IMG term: argininosuccinate lyase (EC 4.3.2.1). (500 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, PurE protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (129 aa) |
| | ilvD-1 | Dihydroxyacid dehydratase/phosphogluconate dehydratase. (583 aa) |
| | Mtc_0543 | Glycosyltransferase. (392 aa) |
| | glmU-1 | UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase. (410 aa) |
| | Mtc_0555 | Glycosyltransferase. (434 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (330 aa) |
| | guaB | Inosine-5''-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (491 aa) |
| | leuC-1 | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (425 aa) |
| | leuD-1 | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (181 aa) |
| | purC | IMG term: phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6); Belongs to the SAICAR synthetase family. (238 aa) |
| | Mtc_0644 | Sucrose-phosphate phosphatase-like hydrolase, Archaeal; Catalyzes the dephosphorylation of 2-phosphoglycolate. (224 aa) |
| | rfbM | Mannose-1-phosphate guanylyltransferase; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis. (391 aa) |
| | glyA | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (437 aa) |
| | serB-1 | Phosphoserine phosphatase SerB. (239 aa) |
| | Mtc_0686 | Putative flavoprotein. (173 aa) |
| | argD | Acetylornithine and succinylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (395 aa) |
| | mfnA | Tyrosine decarboxylase MnfA; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily. (379 aa) |
| | ppsA | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (772 aa) |
| | Mtc_0808 | Glucoamylase and related glycosyl hydrolase. (586 aa) |
| | rpi | Ribose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (231 aa) |
| | purD | IMG term: phosphoribosylamine--glycine ligase (EC 6.3.4.13); Belongs to the GARS family. (437 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (429 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (359 aa) |
| | ilvD-2 | IMG term: dihydroxyacid dehydratase (EC 4.2.1.9); Belongs to the IlvD/Edd family. (548 aa) |
| | porC-1 | IMG term: pyruvate ferredoxin oxidoreductase, gamma subunit (EC 1.2.7.1). (179 aa) |
| | porD-1 | IMG term: pyruvate ferredoxin oxidoreductase, delta subunit (EC 1.2.7.1). (94 aa) |
| | porA-1 | IMG term: pyruvate ferredoxin oxidoreductase, alpha subunit (EC 1.2.7.1). (399 aa) |
| | porB-1 | IMG term: pyruvate ferredoxin oxidoreductase, beta subunit (EC 1.2.7.1). (307 aa) |
| | purO | IMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. (200 aa) |
| | Mtc_0877 | Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (342 aa) |
| | fumB | IMG term: fumarate hydratase beta subunit (EC 4.2.1.2). (193 aa) |
| | fumA | IMG term: fumarate hydratase alpha subunit (EC 4.2.1.2). (286 aa) |
| | Mtc_0921 | Fe-S oxidoreductase. (473 aa) |
| | pgk-1 | IMG term: phosphoglycerate kinase [EC:2.7.2.3]; Belongs to the phosphoglycerate kinase family. (416 aa) |
| | mat | IMG term: methionine adenosyltransferase (EC 2.5.1.6). (370 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (294 aa) |
| | gpmA-1 | IMG term: phosphoglycerate mutase (EC 5.4.2.1). (395 aa) |
| | surE | 5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (266 aa) |
| | fbp | IMG term: D-fructose 1,6-bisphosphatase (EC 3.1.3.11). (273 aa) |
| | Mtc_1056 | IMG term: glycerol-3-phosphate dehydrogenase (quinone) subunit A (EC 1.1.5.3). (441 aa) |
| | rbcL | IMG term: ribulose 1,5-bisphosphate carboxylase large subunit (EC 4.1.1.39). (389 aa) |
| | sudA | IMG term: sulfide dehydrogenase (flavoprotein) subunit SudA (EC 1.8.1.-). (466 aa) |
| | purQ | IMG term: phosphoribosylformylglycinamidine synthase subunit I (EC 6.3.5.3). (277 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (991 aa) |
| | dapA-2 | IMG term: dihydrodipicolinate synthase (EC 4.2.1.52). (297 aa) |
| | prsA-2 | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (284 aa) |
| | pgm-1 | IMG term: alpha-phosphoglucomutase (EC 5.4.2.2); IMG term: phosphomannomutase (EC 5.4.2.8); Belongs to the phosphohexose mutase family. (445 aa) |
| | purB | IMG term: Adenylosuccinate lyase (EC 4.3.2.2); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (461 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (216 aa) |
| | icd | IMG term: isocitrate dehydrogenase (NADP) (EC 1.1.1.42). (337 aa) |
| | ribC | IMG term: riboflavin synthase alpha chain (EC 2.5.1.9). (154 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (144 aa) |
| | Mtc_1359 | Aspartate aminotransferase. (385 aa) |
| | Mtc_1379 | Putative aspartate/tyrosine/aromatic aminotransferase. (369 aa) |
| | aroB | 3-dehydroquinate synthase II; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. (374 aa) |
| | aroF | 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (275 aa) |
| | pgk-2 | IMG term: phosphoglycerate kinase (EC 2.7.2.3); Belongs to the phosphoglycerate kinase family. (410 aa) |
| | Mtc_1389 | Putative pyruvate carboxyltransferase. (462 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (278 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (427 aa) |
| | Mtc_1410 | IMG term: LL-diaminopimelate aminotransferase apoenzyme (EC 2.6.1.83). (385 aa) |
| | Mtc_1458 | Acetyl-CoA acetyltransferase. (378 aa) |
| | Mtc_1472 | IMG term: glycerate 2-kinase (EC 2.7.1.-). (457 aa) |
| | Mtc_1473 | Putative arylsulfatase A and related enzyme. (378 aa) |
| | hisE | IMG term: phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31). (94 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (292 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (424 aa) |
| | trpB-2 | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (444 aa) |
| | lysC | IMG term: aspartate kinase (EC 2.7.2.4); Belongs to the aspartokinase family. (463 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (126 aa) |
| | Mtc_1542 | FAD/FMN-containing dehydrogenase. (455 aa) |
| | aksF | IMG term: 3-isopropylmalate dehydrogenase (EC 1.1.1.85). (323 aa) |
| | leuD-2 | 3-isopropylmalate dehydratase, small subunit; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD [...] (157 aa) |
| | leuC-2 | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (412 aa) |
| | aksA | Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (395 aa) |
| | pfkA-1 | 6-phosphofructokinase. (328 aa) |
| | metX | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (489 aa) |
| | Mtc_1605 | IMG term: cystathionine gamma-lyase (EC 4.4.1.1). (385 aa) |
| | gpmA-2 | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, archaeal form; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (414 aa) |
| | ubiX | Polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (201 aa) |
| | Mtc_1657 | Haloacid dehalogenase superfamily, subfamily IA; Variant 1 with third motif having Dx(3-4)D or Dx(3-4)E. (209 aa) |
| | Mtc_1661 | ATP sulfurylase (sulfate adenylyltransferase). (558 aa) |
| | aroA-3 | Putative phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (264 aa) |
| | metE | Methionine synthase (B12-independent). (294 aa) |
| | Mtc_1710 | Magnesium chelatase subunit ChlI. (389 aa) |
| | pyk | IMG term: pyruvate kinase (EC 2.7.1.40); Belongs to the pyruvate kinase family. (583 aa) |
| | porD-2 | IMG term: pyruvate ferredoxin oxidoreductase, delta subunit (EC 1.2.7.1). (96 aa) |
| | porC-2 | IMG term: pyruvate ferredoxin oxidoreductase, gamma subunit (EC 1.2.7.1). (180 aa) |
| | porA-2 | IMG term: pyruvate ferredoxin oxidoreductase, alpha subunit (EC 1.2.7.1). (365 aa) |
| | porB-2 | IMG term: pyruvate ferredoxin oxidoreductase, beta subunit (EC 1.2.7.1). (295 aa) |
| | thrC-1 | L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (408 aa) |
| | hisC | IMG term: histidinol phosphate aminotransferase apoenzyme (EC 2.6.1.9). (367 aa) |
| | Mtc_1871 | Putative nucleotide kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (168 aa) |
| | thrA | IMG term: homoserine dehydrogenase (EC 1.1.1.3). (328 aa) |
| | pdhA | Pyruvate dehydrogenase E1 component, alpha subunit. (364 aa) |
| | pdhB | Pyruvate dehydrogenase complex E1, dehydrogenase. (324 aa) |
| | pdhC | Pyruvate dehydrogenase complex E2, dihydrolipoamide acyltransferase. (388 aa) |
| | pdhD | Pyruvate dehydrogenase complex E3, dihydrolipoamide dehydrogenase. (471 aa) |
| | acs-1 | Acyl-coenzyme A synthetases/AMP-(fatty) acid ligase. (554 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (152 aa) |
| | Mtc_1963 | Putative methylase involved in ubiquinone/menaquinone biosynthesis. (296 aa) |
| | rfbD-2 | IMG term: dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133). (288 aa) |
| | glmU-2 | UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase. (407 aa) |
| | glmU-3 | UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase. (400 aa) |
| | thrC-2 | L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (387 aa) |
| | hisA | IMG term: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC 5.3.1.16). (239 aa) |
| | hisB | IMG term: imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19). (192 aa) |
| | Mtc_2113 | Alpha-amylase/alpha-mannosidase. (484 aa) |
| | Mtc_2115 | Glycosyltransferase. (431 aa) |
| | leuD-3 | IMG term: 3-isopropylmalate dehydratase, small subunit (EC 4.2.1.33). (170 aa) |
| | leuC-3 | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (417 aa) |
| | Mtc_2158 | Putative aminotransferase, MocR family. (412 aa) |
| | asnB-2 | Asparagine synthase (glutamine-hydrolyzing). (455 aa) |
| | acs-2 | Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase. (579 aa) |
| | Mtc_2257 | IMG term: glycerol-3-phosphate dehydrogenase (quinone) subunit B (EC 1.1.5.3). (328 aa) |
| | eno-2 | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (415 aa) |
| | mvk | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (299 aa) |
| | Mtc_2284 | Isopentenyl phosphate kinase; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. (254 aa) |
| | fni | Isopentenyl-diphosphate delta-isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (357 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (570 aa) |
| | argF | IMG term: ornithine carbamoyltransferase (EC 2.1.3.3); Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (303 aa) |
| | metK | IMG term: methionine adenosyltransferase (EC 2.5.1.6). (382 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (273 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (471 aa) |
| | argJ | N-acetylglutamate synthase / glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (393 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (335 aa) |
| | ribL | FMN adenylyltransferase; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme. (139 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (196 aa) |
| | purP | Putative 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. (362 aa) |
| | pheA | IMG term: prephenate dehydratase (EC 4.2.1.51). (270 aa) |
| | Mtc_2446 | hydroxymethylglutaryl-CoA synthase, putative; Belongs to the thiolase-like superfamily. UPF0219 family. (347 aa) |
| | Mtc_2447 | Acetyl-CoA acetyltransferase. (392 aa) |
| | hisG | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (285 aa) |
| | argG | IMG term: argininosuccinate synthase (EC 6.3.4.5); Belongs to the argininosuccinate synthase family. Type 1 subfamily. (393 aa) |
| | fbaA | IMG term: fructose-bisphosphate aldolase (EC 4.1.2.13). (307 aa) |
| | pfp | Pyrophosphate-dependent phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (343 aa) |
