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| | BAK46012.1 | Hypothetical protein; Belongs to the cysteine synthase/cystathionine beta- synthase family. (310 aa) |
| | DapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (280 aa) |
| | ThrA | Homoserine dehydrogenase. (400 aa) |
| | BAK46174.1 | Hypothetical protein; Belongs to the UPF0735 family. (147 aa) |
| | leuA | Hypothetical protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (551 aa) |
| | HisF-2 | Imidazoleglycerol-phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (256 aa) |
| | HisH | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (201 aa) |
| | ProA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (426 aa) |
| | GltD | NADPH-dependent glutamate synthase beta chain; Related oxidoreductase. (493 aa) |
| | GltB | Glutamate synthase domain 2. (1531 aa) |
| | BAK46344.1 | Hypothetical protein; Belongs to the glutamine synthetase family. (696 aa) |
| | AsnB | Asparagine synthase; Glutamine-hydrolyzing. (527 aa) |
| | BAK46347.1 | Hypothetical protein; Belongs to the glutamine synthetase family. (404 aa) |
| | eno | Hypothetical protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (433 aa) |
| | BAK46468.1 | Hypothetical protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (315 aa) |
| | GltA | Citrate synthase; Belongs to the citrate synthase family. (444 aa) |
| | pfkA | Hypothetical protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (324 aa) |
| | ProC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (270 aa) |
| | asnA | Hypothetical protein. (336 aa) |
| | dapB | Hypothetical protein; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (254 aa) |
| | dapA | Hypothetical protein; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa) |
| | AvtA | PLP-dependent aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (405 aa) |
| | BAK46523.1 | Hypothetical protein; Belongs to the HisA/HisF family. (276 aa) |
| | SerB | Phosphoserine phosphatase. (202 aa) |
| | TrpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (340 aa) |
| | MetE | Methionine synthase II; Cobalamin-independent. (371 aa) |
| | arcB | Hypothetical protein; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (330 aa) |
| | BAK46728.1 | Hypothetical protein. (587 aa) |
| | AcnA | Aconitase A. (760 aa) |
| | BAK46821.1 | Hypothetical protein. (394 aa) |
| | aroA | Hypothetical protein; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (502 aa) |
| | BAK46858.1 | Hypothetical protein. (394 aa) |
| | metAS | Hypothetical protein; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. (325 aa) |
| | BAK46890.1 | Hypothetical protein. (313 aa) |
| | BAK46891.1 | Hypothetical protein. (308 aa) |
| | BAK46917.1 | Hypothetical protein. (429 aa) |
| | BAK47040.1 | Hypothetical protein. (200 aa) |
| | BAK47128.1 | Hypothetical protein; Belongs to the ribose-phosphate pyrophosphokinase family. (394 aa) |
| | aroK | Hypothetical protein; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (175 aa) |
| | MetK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (395 aa) |
| | BAK47204.1 | Hypothetical protein. (338 aa) |
| | BAK47290.1 | Hypothetical protein; Belongs to the glutamine synthetase family. (703 aa) |
| | BAK47304.1 | Hypothetical protein; Belongs to the pyruvate kinase family. (584 aa) |
| | MetH-2 | Methionine synthase I, methyltransferase domain; Cobalamin-dependent. (464 aa) |
| | Fba-2 | Fructose/tagatose bisphosphate aldolase. (312 aa) |
| | Fba-3 | Fructose/tagatose bisphosphate aldolase. (292 aa) |
| | BAK47617.1 | Hypothetical protein. (577 aa) |
| | IlvH | Acetolactate synthase, small subunit. (170 aa) |
| | BAK47619.1 | Hypothetical protein. (340 aa) |
| | hisC | Hypothetical protein; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (354 aa) |
| | GlyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (413 aa) |
| | GltA-2 | Citrate synthase; Belongs to the citrate synthase family. (453 aa) |
| | AroB | 3-dehydroquinate synthetase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (371 aa) |
| | BAK47904.1 | Hypothetical protein. (451 aa) |
| | BAK47920.1 | Hypothetical protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (344 aa) |
| | argC | Hypothetical protein; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (331 aa) |
| | AvtA-3 | PLP-dependent aminotransferase. (394 aa) |
| | dapA-2 | Hypothetical protein; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa) |
| | BAK48000.1 | Hypothetical protein; Belongs to the aspartokinase family. (437 aa) |
| | BAK48006.1 | Hypothetical protein. (335 aa) |
| | BAK48009.1 | Hypothetical protein. (424 aa) |
| | BAK48028.1 | Hypothetical protein; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1168 aa) |
| | BAK48047.1 | Hypothetical protein. (403 aa) |
| | argG | Hypothetical protein; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (408 aa) |
| | RimI | Acetyltransferase. (150 aa) |
| | ArgJ | Predicted kinase related to thiamine pyrophosphokinase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (407 aa) |
| | ArgB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (290 aa) |
| | ArgD-2 | PLP-dependent aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (401 aa) |
| | aroC | Hypothetical protein; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (366 aa) |
| | LeuB-2 | Isocitrate/isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (366 aa) |
| | ilvD | Hypothetical protein; Belongs to the IlvD/Edd family. (558 aa) |
| | BAK48154.1 | Hypothetical protein. (563 aa) |
| | serC | Hypothetical protein; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (365 aa) |
| | BAK48156.1 | Hypothetical protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (387 aa) |
| | TrpE | Anthranilate/para-aminobenzoate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismat [...] (466 aa) |
| | BAK48170.1 | Hypothetical protein. (189 aa) |
| | trpC | Hypothetical protein; Belongs to the TrpC family. (274 aa) |
| | trpF | Hypothetical protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine; Belongs to the TrpF family. (621 aa) |
| | trpA | Chloride channel protein EriC; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (261 aa) |
| | BAK48224.1 | Hypothetical protein. (267 aa) |
| | hisI | Hypothetical protein; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (124 aa) |
| | hisB | Hypothetical protein. (196 aa) |
| | HisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (431 aa) |
| | hisG | ATP phosphoribosyltransferase involved in histidine biosynthesis; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (215 aa) |
| | hisZ | ATP phosphoribosyltransferase involved in histidine biosynthesis; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (396 aa) |
| | proB | Hypothetical protein; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (295 aa) |
| | PheA | Chorismate mutase. (287 aa) |
| | Icd | Isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (403 aa) |
| | BAK48332.1 | Hypothetical protein. (460 aa) |
| | BAK48346.1 | Hypothetical protein. (337 aa) |
| | TyrA | Prephenate dehydrogenase. (366 aa) |
| | BAK48373.1 | Hypothetical protein. (494 aa) |
| | leuD | Hypothetical protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (163 aa) |
| | leuC | Hypothetical protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (418 aa) |
| | IlvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa) |
| | BAK48377.1 | Hypothetical protein. (167 aa) |
| | BAK48380.1 | Hypothetical protein; Belongs to the aspartate-semialdehyde dehydrogenase family. (361 aa) |
| | ArgH | Argininosuccinate lyase. (467 aa) |
| | aroK-2 | Hypothetical protein; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (175 aa) |
| | aroD | Hypothetical protein; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (258 aa) |
| | BAK48404.1 | Hypothetical protein; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (342 aa) |
| | BAK48415.1 | Hypothetical protein. (302 aa) |
| | gpmI | Hypothetical protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (515 aa) |
| | tpiA | Hypothetical protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa) |
| | pgk | Hypothetical protein; Belongs to the phosphoglycerate kinase family. (401 aa) |
| | GapA | Erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (337 aa) |
| | HIS2 | Histidinol phosphatase; Related hydrolase of the PHP family; Belongs to the PHP hydrolase family. HisK subfamily. (267 aa) |
| | BAK48469.1 | Hypothetical protein. (151 aa) |
| | CysE | Serine acetyltransferase. (152 aa) |
| | BAK48558.1 | Hypothetical protein; Belongs to the ribulose-phosphate 3-epimerase family. (219 aa) |
