(30 nodes) Mixed, incl. Amino acid salvage, and Actin filament binding network (Trichoderma asperellum)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	A0A2T3YQD8	Fungal_trans domain-containing protein. (562 aa)
	UTR4	Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (251 aa)
	ADI1	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (172 aa)
	KAE1	tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (379 aa)
	A0A2T3YUK8	Zn(2)-C6 fungal-type domain-containing protein. (404 aa)
	A0A2T3YV89	Zn(2)-C6 fungal-type domain-containing protein. (668 aa)
	A0A2T3YVI0	Aldolase_II domain-containing protein. (317 aa)
	A0A2T3YZY4	Nudix hydrolase domain-containing protein. (202 aa)
	A0A2T3Z0E6	Zn(2)-C6 fungal-type domain-containing protein. (665 aa)
	A0A2T3Z1G3	Fungal_trans domain-containing protein. (521 aa)
	A0A2T3Z339	Uncharacterized protein. (252 aa)
	MRI1	Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. (386 aa)
	A0A2T3Z8L3	Uncharacterized protein. (163 aa)
	A0A2T3ZBU6	Uncharacterized protein. (245 aa)
	A0A2T3ZDM9	Uncharacterized protein. (272 aa)
	A0A2T3ZDR5	Uncharacterized protein. (265 aa)
	A0A2T3ZE34	YrdC-like domain-containing protein. (438 aa)
	MDE1	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). (251 aa)
	A0A2T3ZF77	Zn(2)-C6 fungal-type domain-containing protein. (460 aa)
	A0A2T3ZFU6	Uncharacterized protein; Belongs to the CGI121/TPRKB family. (197 aa)
	A0A2T3ZFY6	Uncharacterized protein. (294 aa)
	A0A2T3ZGC3	Zn(2)-C6 fungal-type domain-containing protein. (419 aa)
	A0A2T3ZHC4	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (307 aa)
	A0A2T3ZHR6	4HBT domain-containing protein. (164 aa)
	A0A2T3ZIU5	Uncharacterized protein. (396 aa)
	A0A2T3ZL83	4HBT domain-containing protein. (159 aa)
	A0A2T3ZMM4	4HBT domain-containing protein. (177 aa)
	A0A2T3ZQ53	tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. (1514 aa)
	A0A2T3ZQ54	Uncharacterized protein. (1509 aa)
	A0A2T3ZQF0	Protein kinase domain-containing protein. (259 aa)

Your Current Organism:

Trichoderma asperellum

NCBI taxonomy Id: 1042311
Other names: T. asperellum CBS 433.97, Trichoderma asperellum CBS 433.97

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A2T3YQD8	A0A2T3Z339	A0A2T3YQD8	A0A2T3Z339	Fungal_trans domain-containing protein.	Uncharacterized protein.	0.790
A0A2T3YQD8	A0A2T3ZHC4	A0A2T3YQD8	A0A2T3ZHC4	Fungal_trans domain-containing protein.	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	0.694
A0A2T3YQD8	A0A2T3ZQ54	A0A2T3YQD8	A0A2T3ZQ54	Fungal_trans domain-containing protein.	Uncharacterized protein.	0.492
A0A2T3YQD8	ADI1	A0A2T3YQD8	A0A2T3YS74	Fungal_trans domain-containing protein.	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	0.746
A0A2T3YQD8	MRI1	A0A2T3YQD8	A0A2T3Z3J8	Fungal_trans domain-containing protein.	Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.	0.766
A0A2T3YQD8	UTR4	A0A2T3YQD8	A0A2T3YRZ2	Fungal_trans domain-containing protein.	Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	0.680
A0A2T3YV89	A0A2T3Z339	A0A2T3YV89	A0A2T3Z339	Zn(2)-C6 fungal-type domain-containing protein.	Uncharacterized protein.	0.790
A0A2T3YV89	A0A2T3ZHC4	A0A2T3YV89	A0A2T3ZHC4	Zn(2)-C6 fungal-type domain-containing protein.	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	0.694
A0A2T3YV89	A0A2T3ZQ54	A0A2T3YV89	A0A2T3ZQ54	Zn(2)-C6 fungal-type domain-containing protein.	Uncharacterized protein.	0.492
A0A2T3YV89	ADI1	A0A2T3YV89	A0A2T3YS74	Zn(2)-C6 fungal-type domain-containing protein.	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	0.746
A0A2T3YV89	MRI1	A0A2T3YV89	A0A2T3Z3J8	Zn(2)-C6 fungal-type domain-containing protein.	Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.	0.766
A0A2T3YV89	UTR4	A0A2T3YV89	A0A2T3YRZ2	Zn(2)-C6 fungal-type domain-containing protein.	Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	0.680
A0A2T3YVI0	A0A2T3Z339	A0A2T3YVI0	A0A2T3Z339	Aldolase_II domain-containing protein.	Uncharacterized protein.	0.790
A0A2T3YVI0	A0A2T3ZHC4	A0A2T3YVI0	A0A2T3ZHC4	Aldolase_II domain-containing protein.	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	0.694
A0A2T3YVI0	A0A2T3ZQ54	A0A2T3YVI0	A0A2T3ZQ54	Aldolase_II domain-containing protein.	Uncharacterized protein.	0.492
A0A2T3YVI0	ADI1	A0A2T3YVI0	A0A2T3YS74	Aldolase_II domain-containing protein.	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	0.746
A0A2T3YVI0	MRI1	A0A2T3YVI0	A0A2T3Z3J8	Aldolase_II domain-containing protein.	Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.	0.766
A0A2T3YVI0	UTR4	A0A2T3YVI0	A0A2T3YRZ2	Aldolase_II domain-containing protein.	Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	0.680
A0A2T3Z0E6	A0A2T3Z339	A0A2T3Z0E6	A0A2T3Z339	Zn(2)-C6 fungal-type domain-containing protein.	Uncharacterized protein.	0.790
A0A2T3Z0E6	A0A2T3ZHC4	A0A2T3Z0E6	A0A2T3ZHC4	Zn(2)-C6 fungal-type domain-containing protein.	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	0.694