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GQS_02615 GQS_02615 GQS_03225 GQS_03225 uppS uppS GQS_03690 GQS_03690 GQS_04340 GQS_04340 GQS_04525 GQS_04525 fni fni GQS_04565 GQS_04565 mvk mvk GQS_05050 GQS_05050 GQS_05060 GQS_05060 GQS_05160 GQS_05160 ubiA ubiA GQS_05665 GQS_05665 GQS_06625 GQS_06625 GQS_06890 GQS_06890 carS carS GQS_07940 GQS_07940 GQS_08765 GQS_08765 GQS_08825 GQS_08825 GQS_09005 GQS_09005 GQS_09010 GQS_09010 GQS_09070 GQS_09070 GQS_09125 GQS_09125 GQS_09425 GQS_09425 GQS_09430 GQS_09430 GQS_09735 GQS_09735 GQS_09970 GQS_09970 GQS_10240 GQS_10240 egsA egsA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GQS_02615Membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase; COG5305 Predicted membrane protein. (744 aa)
GQS_03225COG1257 Hydroxymethylglutaryl-CoA reductase; Belongs to the HMG-CoA reductase family. (408 aa)
uppSUndecaprenyl pyrophosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids. (264 aa)
GQS_03690Geranylgeranyl hydrogenase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. (396 aa)
GQS_04340Hypothetical protein; COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family. (469 aa)
GQS_04525Bifunctional short chain isoprenyl diphosphate synthase (idsA); COG0142 Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (343 aa)
fniIsopentenyl pyrophosphate isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (372 aa)
GQS_04565Aspartate/glutamate/uridylate kinase, Fosfomycin resistance kinase FomA-like protein (fomA); Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. (263 aa)
mvkMevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (334 aa)
GQS_05050methylmalonyl-CoA decarboxylase alpha chain; COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). (522 aa)
GQS_05060COG0511 Biotin carboxyl carrier protein. (155 aa)
GQS_05160Indolepyruvate ferredoxin oxidoreductase, alpha subunit; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (632 aa)
ubiAPrenyltransferase UbiA-like protein; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. (276 aa)
GQS_05665Hypothetical protein; COG1657 Squalene cyclase. (741 aa)
GQS_06625Phospholipase D-related protein; COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes. (246 aa)
GQS_06890COG0644 Dehydrogenases (flavoproteins). (370 aa)
carSHypothetical protein; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. (171 aa)
GQS_07940Oxidoreductase; COG1233 Phytoene dehydrogenase and related proteins. (420 aa)
GQS_08765Membrane protein, conserved; COG1657 Squalene cyclase. (589 aa)
GQS_08825COG3568 Metal-dependent hydrolase. (581 aa)
GQS_09005Hypothetical protein; COG3425 3-hydroxy-3-methylglutaryl CoA synthase; Belongs to the thiolase-like superfamily. UPF0219 family. (350 aa)
GQS_09010COG0183 Acetyl-CoA acetyltransferase. (386 aa)
GQS_09070Indolepyruvate oxidoreductase subunit iorA; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (648 aa)
GQS_09125UbiA prenyltransferase family protein; COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases. (269 aa)
GQS_09425COG1260 Myo-inositol-1-phosphate synthase. (382 aa)
GQS_09430Bifunctional phosphosugar nucleotidyltransferase/CDP-alcohol phosphatidyltransferase; COG1213 Predicted sugar nucleotidyltransferases; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (432 aa)
GQS_09735CDP-alcohol phosphatidyltransferase; COG0558 Phosphatidylglycerophosphate synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (188 aa)
GQS_09970COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. (562 aa)
GQS_10240Geranylgeranylglyceryl phosphate synthase-like protein; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. (253 aa)
egsANAD(P)-dependent glycerol-1-phosphate dehydrogenase; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. Belongs to the glycerol-1-phosphate dehydrogenase family. (346 aa)
Your Current Organism:
Thermococcus sp. 4557
NCBI taxonomy Id: 1042877
Other names: T. sp. 4557
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