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rpl24e rpl24e rad50 rad50 mre11 mre11 GQS_00690 GQS_00690 GQS_00695 GQS_00695 GQS_00700 GQS_00700 GQS_00725 GQS_00725 GQS_00805 GQS_00805 cobB cobB adk adk rnhB rnhB mptA mptA GQS_01250 GQS_01250 htpX htpX corA corA dacZ dacZ GQS_01695 GQS_01695 rpl37e rpl37e thiC thiC thi4 thi4 cysS cysS GQS_02270 GQS_02270 GQS_02345 GQS_02345 GQS_02350 GQS_02350 GQS_02355 GQS_02355 GQS_02430 GQS_02430 GQS_02475 GQS_02475 rpl37ae rpl37ae rpoP rpoP GQS_03110 GQS_03110 tdh tdh csl4 csl4 thrS thrS amzA amzA rgy rgy GQS_03600 GQS_03600 dtdA dtdA pckG pckG GQS_03930 GQS_03930 GQS_03950 GQS_03950 GQS_03955 GQS_03955 GQS_04005 GQS_04005 rpl44e rpl44e rps27e rps27e pgiA pgiA rnz rnz hypA hypA GQS_04235 GQS_04235 GQS_04240 GQS_04240 GQS_04245 GQS_04245 GQS_04445 GQS_04445 rnj rnj rpoN rpoN rps14P rps14P GQS_04990 GQS_04990 GQS_05090 GQS_05090 GQS_05305 GQS_05305 GQS_05345 GQS_05345 spt4 spt4 rps27ae rps27ae ileS ileS pyrC pyrC alaS alaS GQS_07025 GQS_07025 kae1 kae1 GQS_07460 GQS_07460 GQS_07530 GQS_07530 GQS_08040 GQS_08040 GQS_08100 GQS_08100 GQS_08450 GQS_08450 GQS_08680 GQS_08680 GQS_08745 GQS_08745 queC queC GQS_09035 GQS_09035 GQS_09110 GQS_09110 tfb tfb tdk tdk rnp4 rnp4 GQS_09930 GQS_09930 tfb-2 tfb-2 GQS_10175 GQS_10175
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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rpl24e50S ribosomal protein L24e; Binds to the 23S rRNA. (68 aa)
rad50Chromosome segregation protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. (887 aa)
mre11DNA double-strand break repair protein mre11 (mre11); Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. (470 aa)
GQS_00690Sor superoxide reductase; COG2033 Desulfoferrodoxin. (115 aa)
GQS_00695Rubredoxin; Rubredoxin is a small nonheme, iron protein lacking acid- labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule. (53 aa)
GQS_00700COG1592 Rubrerythrin. (171 aa)
GQS_00725Cadmium-translocating P-type ATPase; COG2217 Cation transport ATPase. (689 aa)
GQS_00805COG1594 DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (110 aa)
cobBCOG0846 NAD-dependent protein deacetylases, SIR2 family; Belongs to the sirtuin family. Class III subfamily. (250 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (224 aa)
rnhBRibonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (231 aa)
mptAGTP cyclohydrolase; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. (268 aa)
GQS_01250Putative ATPase RIL; COG1245 Predicted ATPase, RNase L inhibitor (RLI) homolog. (591 aa)
htpXHeat shock protein HtpX; COG0501 Zn-dependent protease with chaperone function; Belongs to the peptidase M48B family. (292 aa)
corAMagnesium and cobalt transporter; Mediates influx of magnesium ions. Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. (327 aa)
dacZHypothetical protein; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. (267 aa)
GQS_01695COG1918 Fe2+ transport system protein A. (75 aa)
rpl37e50S ribosomal protein L37e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (63 aa)
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (426 aa)
thi4Ribulose-1,5-biphosphate synthetase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (250 aa)
cysSCOG0215 Cysteinyl-tRNA synthetase. (476 aa)
GQS_02270COG0501 Zn-dependent protease with chaperone function. (285 aa)
GQS_02345COG1035 Coenzyme F420-reducing hydrogenase, beta subunit. (276 aa)
GQS_02350COG1941 Coenzyme F420-reducing hydrogenase, gamma subunit. (230 aa)
GQS_02355COG3259 Coenzyme F420-reducing hydrogenase, alpha subunit. (392 aa)
GQS_02430Formate hydrogenlyase II subunit F; COG3262 Ni,Fe-hydrogenase III component G. (544 aa)
GQS_02475COG3259 Coenzyme F420-reducing hydrogenase, alpha subunit. (429 aa)
rpl37ae50S ribosomal protein L37Ae; Binds to the 23S rRNA. (86 aa)
rpoPDNA-directed RNA polymerase subunit P; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. (49 aa)
GQS_03110COG1085 Galactose-1-phosphate uridylyltransferase. (327 aa)
tdhL-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (350 aa)
csl4Exosome complex RNA-binding protein Csl4; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. (196 aa)
thrSCOG0441 Threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (626 aa)
amzAArchemetzincin-like protein; Probable zinc metalloprotease whose natural substrate is unknown. (184 aa)
rgyReverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. (1226 aa)
GQS_03600Hypothetical protein. (176 aa)
dtdAHypothetical protein; D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo. (272 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (625 aa)
GQS_03930Phospholipase C/P1 nuclease family protein, putative. (431 aa)
GQS_03950DNA-directed RNA polymerase subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1122 aa)
GQS_03955DNA-directed RNA polymerase subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (905 aa)
GQS_04005Hypothetical protein; Involved in DNA damage repair. (422 aa)
rpl44e50S ribosomal protein L44e; Binds to the 23S rRNA. (94 aa)
rps27eCOG2051 Ribosomal protein S27E. (65 aa)
pgiACOG2140 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes; Belongs to the archaeal-type GPI family. (189 aa)
rnzRibonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (314 aa)
hypAHydrogenase nickel incorporation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (139 aa)
GQS_04235Hydrogenase expression/formation protein HypC; COG0298 Hydrogenase maturation factor. (74 aa)
GQS_04240Hydrogenase isoenzymes formation protein HypD; COG0409 Hydrogenase maturation factor. (372 aa)
GQS_04245COG0068 Hydrogenase maturation factor. (772 aa)
GQS_04445Nickel responsive regulator; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family. (138 aa)
rnjMetallo-beta-lactamase superfamily hydrolase; An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily. (444 aa)
rpoNDNA-directed RNA polymerase subunit N; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family. (65 aa)
rps14P30S ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles. (56 aa)
GQS_04990H-II alpha (hydrogenase subunit alpha); COG3259 Coenzyme F420-reducing hydrogenase, alpha subunit. (415 aa)
GQS_05090Protein, conserved, containing ZPR1 zinc-finger domain; COG1779 C4-type Zn-finger protein. (224 aa)
GQS_05305COG0648 Endonuclease IV. (281 aa)
GQS_05345COG1321 Mn-dependent transcriptional regulator. (145 aa)
spt4DNA-directed RNA polymerase subunit E; Stimulates transcription elongation; Belongs to the archaeal Spt4 family. (62 aa)
rps27aeCOG1998 Ribosomal protein S27AE; Belongs to the eukaryotic ribosomal protein eS31 family. (57 aa)
ileSisoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1067 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (410 aa)
alaSalanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (913 aa)
GQS_07025COG0308 Aminopeptidase N. (582 aa)
kae1UGMP family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. (325 aa)
GQS_07460Membrane-bound hydrogenase MBH 2, subunit Mbh2L (NiFe hydrogenase catalytic subunit); COG3261 Ni,Fe-hydrogenase III large subunit. (412 aa)
GQS_07530COG3261 Ni,Fe-hydrogenase III large subunit. (431 aa)
GQS_08040COG1324 Uncharacterized protein involved in tolerance to divalent cations. (104 aa)
GQS_08100COG2191 Formylmethanofuran dehydrogenase subunit E. (234 aa)
GQS_08450Dioxygenase, putative. (262 aa)
GQS_08680COG2131 Deoxycytidylate deaminase. (177 aa)
GQS_08745COG1141 Ferredoxin. (67 aa)
queCPutative transcription regulator; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (239 aa)
GQS_09035COG1844 Uncharacterized protein conserved in archaea. (140 aa)
GQS_09110Amidase; COG1402 Uncharacterized protein, putative amidase. (237 aa)
tfbTranscription initiation factor IIB; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (303 aa)
tdkCOG1435 Thymidine kinase. (193 aa)
rnp4Ribonuclease P protein component 4; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (139 aa)
GQS_09930Metalloprotease; COG1310 Predicted metal-dependent protease of the PAD1/JAB1 superfamily. (106 aa)
tfb-2Transcription initiation factor IIB; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (299 aa)
GQS_10175Hypothetical protein; COG1387 Histidinol phosphatase and related hydrolases of the PHP family. (218 aa)
Your Current Organism:
Thermococcus sp. 4557
NCBI taxonomy Id: 1042877
Other names: T. sp. 4557
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