STRINGSTRING
mraZ mraZ rsmH rsmH ftsL ftsL ftsI ftsI murE murE murF murF mraY mraY ftsW ftsW murG murG murC murC ddl ddl ftsQ ftsQ ftsA ftsA ftsZ ftsZ DSC_03305 DSC_03305 DSC_03310 DSC_03310 DSC_03315 DSC_03315 DSC_03320 DSC_03320 mrdB mrdB DSC_03330 DSC_03330 rlpA rlpA DSC_04960 DSC_04960 DSC_05035 DSC_05035 murA murA DSC_06970 DSC_06970 glmM glmM DSC_07910 DSC_07910 DSC_10305 DSC_10305 ftsB ftsB DSC_11325 DSC_11325 DSC_11330 DSC_11330 DSC_11335 DSC_11335 murB murB mltG mltG DSC_12405 DSC_12405 DSC_13645 DSC_13645 mpl mpl glmS glmS glmU glmU
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mraZCell division protein MraZ; COG2001 Uncharacterized protein conserved in bacteria; Belongs to the MraZ family. (148 aa)
rsmH16S rRNA m(4)C1402 methyltransferase; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (375 aa)
ftsLCell division protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (87 aa)
ftsICell division protein ftsi; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. (631 aa)
murEUDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (503 aa)
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (495 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (361 aa)
ftsWCell division protein; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (432 aa)
murGUndecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (349 aa)
murCUDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (483 aa)
ddlD-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (318 aa)
ftsQCell division protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. (297 aa)
ftsACell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (411 aa)
ftsZCell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (418 aa)
DSC_03305Rod shape-determining protein MreB; COG1077 Actin-like ATPase involved in cell morphogenesis. (348 aa)
DSC_03310COG1792 Cell shape-determining protein. (402 aa)
DSC_03315Rod shape-determining protein; Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins. Belongs to the MreD family. (159 aa)
DSC_03320COG0768 Cell division protein FtsI/penicillin-binding protein 2. (693 aa)
mrdBSeptum-peptidoglycan biosynthetic protein; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (367 aa)
DSC_03330COG2951 Membrane-bound lytic murein transglycosylase B. (409 aa)
rlpARare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (460 aa)
DSC_04960Penicillin-binding protein 1A; COG5009 Membrane carboxypeptidase/penicillin-binding protein. (822 aa)
DSC_05035Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). (812 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (423 aa)
DSC_06970COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains). (527 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (452 aa)
DSC_07910Penicillin-binding protein 1C; COG4953 Membrane carboxypeptidase/penicillin-binding protein PbpC. (790 aa)
DSC_10305COG1426 Uncharacterized protein conserved in bacteria. (292 aa)
ftsBCell division protein FtsB; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (123 aa)
DSC_11325COG4242 Cyanophycinase and related exopeptidases; Belongs to the peptidase S51 family. (280 aa)
DSC_11330Cyanophycin synthetase; COG1181 D-alanine-D-alanine ligase and related ATP-grasp enzymes. (932 aa)
DSC_11335Mur ligase family protein; COG0769 UDP-N-acetylmuramyl tripeptide synthase. (590 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (346 aa)
mltGPeriplasmic solute-binding protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (375 aa)
DSC_12405COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains). (300 aa)
DSC_13645COG2802 Uncharacterized protein, similar to the N-terminal domain of Lon protease. (192 aa)
mplUDP-N-acetylmuramate-L-alanine ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. (453 aa)
glmSGlucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (610 aa)
glmUGlmu; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (460 aa)
Your Current Organism:
Pseudoxanthomonas spadix
NCBI taxonomy Id: 1045855
Other names: P. spadix BD-a59, Pseudoxanthomonas spadix BD-a59, Pseudoxanthomonas spadix str. BD-a59, Pseudoxanthomonas spadix strain BD-a59
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.