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gidB gidB DSC_00295 DSC_00295 DSC_00900 DSC_00900 bioC bioC DSC_01230 DSC_01230 DSC_01235 DSC_01235 DSC_03605 DSC_03605 trmB trmB DSC_03830 DSC_03830 DSC_04180 DSC_04180 DSC_04690 DSC_04690 DSC_05330 DSC_05330 thyA thyA ksgA ksgA rlmM rlmM DSC_05555 DSC_05555 DSC_05815 DSC_05815 trmJ trmJ DSC_06345 DSC_06345 DSC_06495 DSC_06495 trmD trmD prmB prmB DSC_07230 DSC_07230 rlmJ rlmJ DSC_07560 DSC_07560 DSC_07595 DSC_07595 DSC_08140 DSC_08140 ubiG ubiG DSC_08390 DSC_08390 DSC_08875 DSC_08875 DSC_09195 DSC_09195 DSC_09200 DSC_09200 DSC_09550 DSC_09550 DSC_10030 DSC_10030 rlmN rlmN DSC_10470 DSC_10470 rlmE rlmE pcm pcm rlmB rlmB tpm tpm rlmH rlmH DSC_11350 DSC_11350 rumA rumA DSC_11740 DSC_11740 DSC_11750 DSC_11750 DSC_12015 DSC_12015 rlmL rlmL DSC_12495 DSC_12495 DSC_12500 DSC_12500 prmC prmC DSC_13740 DSC_13740 prmA prmA DSC_14960 DSC_14960 DSC_15155 DSC_15155 DSC_15435 DSC_15435 DSC_15455 DSC_15455 trmL trmL DSC_01670 DSC_01670 DSC_01985 DSC_01985 DSC_02100 DSC_02100 DSC_02135 DSC_02135 DSC_02150 DSC_02150 rsmI rsmI rsmH rsmH ubiE ubiE DSC_03095 DSC_03095 cysG cysG
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gidB16S rRNA methyltransferase GidB; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. (217 aa)
DSC_00295Hypothetical protein. (393 aa)
DSC_00900COG4798 Predicted methyltransferase. (278 aa)
bioCBiotin synthesis protein; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (300 aa)
DSC_01230Hypothetical protein. (212 aa)
DSC_01235Hypothetical protein. (245 aa)
DSC_03605tRNA/rRNA methyltransferase; COG0566 rRNA methylases; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (278 aa)
trmBtRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (244 aa)
DSC_03830COG2020 Putative protein-S-isoprenylcysteine methyltransferase. (221 aa)
DSC_04180Hypothetical protein; COG0827 Adenine-specific DNA methylase. (369 aa)
DSC_0469016S rRNA methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (433 aa)
DSC_0533016S ribosomal RNA methyltransferase RsmE; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (266 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
ksgA16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (270 aa)
rlmMPutative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily. (355 aa)
DSC_05555COG0500 SAM-dependent methyltransferases. (203 aa)
DSC_05815COG2940 Proteins containing SET domain. (155 aa)
trmJtRNA/rRNA methyltransferase; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. (254 aa)
DSC_06345Putative methyltransferase; Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle; Belongs to the methyltransferase superfamily. RsmD family. (184 aa)
DSC_06495Type 12 methyltransferase; COG0500 SAM-dependent methyltransferases. (197 aa)
trmDtRNA (guanine-N(1)-)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (255 aa)
prmBN5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily. (309 aa)
DSC_07230COG0286 Type I restriction-modification system methyltransferase subunit. (541 aa)
rlmJHypothetical protein; Specifically methylates the adenine in position 2030 of 23S rRNA. (285 aa)
DSC_07560COG0500 SAM-dependent methyltransferases. (99 aa)
DSC_07595Hypothetical protein. (39 aa)
DSC_08140COG0286 Type I restriction-modification system methyltransferase subunit. (120 aa)
ubiGBifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. (240 aa)
DSC_083905-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (940 aa)
DSC_08875Putative methyl transferase; COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis. (258 aa)
DSC_09195Hypothetical protein; COG0500 SAM-dependent methyltransferases. (222 aa)
DSC_09200Hypothetical protein; COG0727 Predicted Fe-S-cluster oxidoreductase. (107 aa)
DSC_09550Adenine-specific DNA-methyltransferase; COG2189 Adenine specific DNA methylase Mod. (363 aa)
DSC_10030N-6 DNA methylase; COG0286 Type I restriction-modification system methyltransferase subunit. (495 aa)
rlmNHypothetical protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (403 aa)
DSC_10470Hypothetical protein; COG1352 Methylase of chemotaxis methyl-accepting proteins. (282 aa)
rlmECell division protein FtsJ; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (210 aa)
pcmprotein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. (227 aa)
rlmBtRNA/rRNA methyltransferase; Specifically methylates the ribose of guanosine 2251 in 23S rRNA. (260 aa)
tpmThiopurine S-methyltransferase; COG0500 SAM-dependent methyltransferases; Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. (218 aa)
rlmHrRNA large subunit methyltransferase; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (156 aa)
DSC_11350Type 11 methyltransferase; COG0500 SAM-dependent methyltransferases. (263 aa)
rumA23S rRNA m(5)U1939 methyltransferase; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. (446 aa)
DSC_11740N-6 DNA methylase; COG0286 Type I restriction-modification system methyltransferase subunit. (505 aa)
DSC_11750N-6 DNA methylase; COG0286 Type I restriction-modification system methyltransferase subunit. (507 aa)
DSC_12015Hypothetical protein; COG0500 SAM-dependent methyltransferases. (212 aa)
rlmL23S rRNA m(2)G2445 methyltransferase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. (713 aa)
DSC_12495AraC family transcriptional regulator; COG2169 Adenosine deaminase. (503 aa)
DSC_125006-O-methylguanine-DNA methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (177 aa)
prmCN5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. (298 aa)
DSC_13740COG2518 Protein-L-isoaspartate carboxylmethyltransferase. (218 aa)
prmARibosomal protein L11 methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. (307 aa)
DSC_14960Ribosomal RNA small subunit methyltransferase C; COG2813 16S RNA G1207 methylase RsmC; Belongs to the methyltransferase superfamily. (365 aa)
DSC_15155Hypothetical protein; COG2521 Predicted archaeal methyltransferase. (316 aa)
DSC_15435Hypothetical protein; COG0727 Predicted Fe-S-cluster oxidoreductase. (117 aa)
DSC_15455Hypothetical protein; COG1002 Type II restriction enzyme, methylase subunits. (1131 aa)
trmLtRNA/rRNA methyltransferase; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. (159 aa)
DSC_01670Hypothetical protein; COG1092 Predicted SAM-dependent methyltransferases. (389 aa)
DSC_01985Hypothetical protein. (328 aa)
DSC_02100uroporphyrin-III C-methyltransferase. (346 aa)
DSC_02135COG1002 Type II restriction enzyme, methylase subunits. (197 aa)
DSC_02150Site-specific DNA-methyltransferase (adenine-specific); COG0827 Adenine-specific DNA methylase. (539 aa)
rsmIRibosomal RNA small subunit methyltransferase I; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (272 aa)
rsmH16S rRNA m(4)C1402 methyltransferase; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (375 aa)
ubiEUbiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (253 aa)
DSC_03095COG2852 Uncharacterized protein conserved in bacteria. (113 aa)
cysGSiroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (483 aa)
Your Current Organism:
Pseudoxanthomonas spadix
NCBI taxonomy Id: 1045855
Other names: P. spadix BD-a59, Pseudoxanthomonas spadix BD-a59, Pseudoxanthomonas spadix str. BD-a59, Pseudoxanthomonas spadix strain BD-a59
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