STRINGSTRING
ESN65219.1 ESN65219.1 ESN65220.1 ESN65220.1 ESN65300.1 ESN65300.1 putA putA putP putP sthA sthA ESN62945.1 ESN62945.1 glnA glnA ppc ppc ESN63154.1 ESN63154.1 ESN63273.1 ESN63273.1 pckA pckA ESN63495.1 ESN63495.1 ESN63496.1 ESN63496.1 aspA aspA ESN63628.1 ESN63628.1 ESN63629.1 ESN63629.1 ESN63630.1 ESN63630.1 ESN63631.1 ESN63631.1 ESN63632.1 ESN63632.1 aspA-2 aspA-2 mdh mdh ESN63735.1 ESN63735.1 acs acs nifJ nifJ mmsA mmsA ESN63896.1 ESN63896.1 ESN63916.1 ESN63916.1 ESN64051.1 ESN64051.1 lipA lipA lipB lipB gltA gltA ESN64459.1 ESN64459.1 sdhB sdhB sdhA sdhA sdhD sdhD ESN64463.1 ESN64463.1 ESN64464.1 ESN64464.1 sucC sucC sucD sucD patD patD ygjG ygjG ESN64654.1 ESN64654.1 ESN64703.1 ESN64703.1 nifJ-2 nifJ-2 ESN64984.1 ESN64984.1 dld dld ESN65131.1 ESN65131.1 ESN61760.1 ESN61760.1 fumC fumC prs prs gabD gabD ESN62007.1 ESN62007.1 ESN62044.1 ESN62044.1 acnA acnA ESN62130.1 ESN62130.1 ESN62150.1 ESN62150.1 lplA lplA acnB acnB maeA maeA ackA ackA ESN62463.1 ESN62463.1 ESN62561.1 ESN62561.1 gltA-2 gltA-2 ESN62696.1 ESN62696.1 ESN61430.1 ESN61430.1 acnB-2 acnB-2 lpdA lpdA aceF aceF aceE aceE nifJ-3 nifJ-3 frdA frdA ESN61647.1 ESN61647.1 frdC frdC frdD frdD ESN61070.1 ESN61070.1 proA proA proB proB ESN61181.1 ESN61181.1 ESN61182.1 ESN61182.1 ESN61217.1 ESN61217.1 proC-2 proC-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ESN65219.1KEGG: aceA, isocitrate lyase. (436 aa)
ESN65220.1KEGG: malate synthase; Belongs to the malate synthase family. (532 aa)
ESN65300.1KEGG: MmgE/PrpD family protein. (452 aa)
putAProline dehydrogenase, 1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. (1324 aa)
putPHypothetical protein; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (494 aa)
sthANAD(P)(+) transhydrogenase (B-specific); Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (469 aa)
ESN62945.1KEGG: hypothetical protein. (187 aa)
glnAHypothetical protein; KEGG: glnA, glutamine synthetase. (469 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (879 aa)
ESN63154.1KEGG: Carbon starvation protein A. (601 aa)
ESN63273.1Hypothetical protein; KEGG: aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (512 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (539 aa)
ESN63495.1KEGG: gltD, glutamate synthase, 4Fe-4S protein, small subunit. (472 aa)
ESN63496.1KEGG: gltB, glutamate synthase, large subunit. (1486 aa)
aspAKEGG: aspA1, aspartate ammonia-lyase. (479 aa)
ESN63628.1KEGG: acoX, acetoin catabolism protein X, ATP-NAD kinase AcoX. (359 aa)
ESN63629.1Pyruvate dehydrogenase (acetyl-transferring); KEGG: acetoin dehydrogenase E1 component alpha-subunit. (334 aa)
ESN63630.1Pyruvate dehydrogenase (acetyl-transferring); KEGG: acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit beta. (339 aa)
ESN63631.1Hypothetical protein; KEGG: acoC, branched-chain alpha-keto acid dehydrogenase subunit e2. (373 aa)
ESN63632.1KEGG: biotin/lipoate A/B protein ligase. (266 aa)
aspA-2KEGG: aspA, aspartate ammonia-lyase. (479 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (312 aa)
ESN63735.1KEGG: gamma-aminobutyraldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (487 aa)
acsAcetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (652 aa)
nifJPyruvate dehydrogenase (NADP(+)); KEGG: pyruvate ferredoxin/flavodoxin oxidoreductase. (1177 aa)
mmsAMethylmalonate-semialdehyde dehydrogenase (acylating); KEGG: aldehyde dehydrogenase. (503 aa)
ESN63896.1Hypothetical protein; KEGG: malic enzyme. (759 aa)
ESN63916.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (547 aa)
ESN64051.1Hypothetical protein; KEGG: alcohol dehydrogenase GroES domain-containing protein. (179 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (321 aa)
lipBLipoyl(octanoyl) transferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (233 aa)
gltAHypothetical protein; KEGG: gltA, citrate synthase; Belongs to the citrate synthase family. (427 aa)
ESN64459.1Hypothetical protein; KEGG: sdhC, succinate dehydrogenase cytochrome b556 large membrane subunit. (125 aa)
sdhBHypothetical protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa)
sdhASuccinate dehydrogenase (ubiquinone); Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth. (588 aa)
sdhDKEGG: sdhB, succinate dehydrogenase, FeS subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (238 aa)
ESN64463.1KEGG: 2-oxoglutarate dehydrogenase, E1 subunit. (935 aa)
ESN64464.1Dihydrolipoyllysine-residue succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (409 aa)
sucCSuccinate--CoA ligase (ADP-forming); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
sucDSuccinate--CoA ligase (ADP-forming); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
patDKEGG: gamma-aminobutyraldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (474 aa)
ygjGKEGG: ygjG, ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (472 aa)
ESN64654.1Hypothetical protein; KEGG: betaine aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (490 aa)
ESN64703.1KEGG: iron-containing alcohol dehydrogenase. (388 aa)
nifJ-2Pyruvate dehydrogenase (NADP(+)); KEGG: pyruvate ferredoxin/flavodoxin oxidoreductase. (1201 aa)
ESN64984.1KEGG: putative glutamate synthase (NADPH) small subunit. (593 aa)
dldD-lactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (592 aa)
ESN65131.1KEGG: isocitrate dehydrogenase. (417 aa)
ESN61760.1KEGG: bifunctional acetaldehyde-CoA/alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (899 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)
prsRibose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa)
gabDKEGG: succinic semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (486 aa)
ESN62007.1KEGG: 4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (421 aa)
ESN62044.1D-lactate dehydrogenase; KEGG: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein. (330 aa)
acnAAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (889 aa)
ESN62130.1D-lactate dehydrogenase (cytochrome); KEGG: FAD linked oxidase domain-containing protein. (1017 aa)
ESN62150.1KEGG: aspartate transaminase. (396 aa)
lplAHypothetical protein; Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. Belongs to the LplA family. (338 aa)
acnBKEGG: acnB, aconitate hydratase 2 (citrate hydro-lyase 2) (aconitase 2); Belongs to the aconitase/IPM isomerase family. (865 aa)
maeAKEGG: malate dehydrogenase. (565 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa)
ESN62463.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (712 aa)
ESN62561.1Succinate-semialdehyde dehydrogenase (NAD(P)(+)); KEGG: NAD-dependent aldehyde dehydrogenase. (463 aa)
gltA-2Hypothetical protein; KEGG: Citrate synthase (si); Belongs to the citrate synthase family. (433 aa)
ESN62696.1KEGG: aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (284 aa)
ESN61430.1KEGG: iron-containing alcohol dehydrogenase. (378 aa)
acnB-2Hypothetical protein; KEGG: acnB, bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Belongs to the aconitase/IPM isomerase family. (865 aa)
lpdAKEGG: lpd, lipoamide dehydrogenase, E3 component is part of three enzyme complexes. (474 aa)
aceFDihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (625 aa)
aceEPyruvate dehydrogenase (acetyl-transferring); Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa)
nifJ-3Pyruvate dehydrogenase (NADP(+)); KEGG: pyruvate ferredoxin/flavodoxin oxidoreductase. (1201 aa)
frdASuccinate dehydrogenase; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth. (598 aa)
ESN61647.1Succinate dehydrogenase; KEGG: fumarate reductase iron-sulfur subunit; overlaps another CDS with the same product name; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (244 aa)
frdCHypothetical protein; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (131 aa)
frdDHypothetical protein; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (118 aa)
ESN61070.1KEGG: (S)-mandelate dehydrogenase. (383 aa)
proAGlutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (417 aa)
proBHypothetical protein; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (368 aa)
ESN61181.1Kynurenine--oxoglutarate transaminase; KEGG: putative aminotransferase. (385 aa)
ESN61182.1KEGG: hypothetical protein. (255 aa)
ESN61217.1Hypothetical protein; KEGG: GCN5-like N-acetyltransferase. (887 aa)
proC-2Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (273 aa)
Your Current Organism:
Serratia sp. ATCC 39006
NCBI taxonomy Id: 104623
Other names: S. sp. ATCC 39006
Server load: low (20%) [HD]