STRINGSTRING
ESN65210.1 ESN65210.1 ESN65216.1 ESN65216.1 metAS metAS ilvC ilvC ilvA ilvA ilvD ilvD ilvE ilvE ESN65452.1 ESN65452.1 ESN65453.1 ESN65453.1 metF metF ESN62874.1 ESN62874.1 metE metE ESN63170.1 ESN63170.1 ESN63222.1 ESN63222.1 ESN63241.1 ESN63241.1 serB serB budA budA ESN63743.1 ESN63743.1 cysK cysK ESN63938.1 ESN63938.1 ESN64177.1 ESN64177.1 ESN64178.1 ESN64178.1 ESN64248.1 ESN64248.1 ESN64265.1 ESN64265.1 ESN64616.1 ESN64616.1 serC serC ESN65061.1 ESN65061.1 ESN65114.1 ESN65114.1 ESN62389.1 ESN62389.1 ESN62456.1 ESN62456.1 pdxB pdxB mnmC mnmC ESN62520.1 ESN62520.1 cysS cysS ESN62634.1 ESN62634.1 ESN61403.1 ESN61403.1 ESN61417.1 ESN61417.1 ESN61477.1 ESN61477.1 ESN61478.1 ESN61478.1 leuA leuA leuB leuB leuC leuC leuD leuD ilvB ilvB ESN61492.1 ESN61492.1 ESN61534.1 ESN61534.1 thrB thrB ESN61536.1 ESN61536.1 ESN61547.1 ESN61547.1 metK metK ESN61596.1 ESN61596.1 ESN61669.1 ESN61669.1 ESN61381.1 ESN61381.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ESN65210.1KEGG: metC, cystathionine beta-lyase. (420 aa)
ESN65216.1Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1228 aa)
metASHomoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. (309 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (492 aa)
ilvAHypothetical protein; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (514 aa)
ilvDKEGG: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (616 aa)
ilvEBranched-chain-amino-acid transaminase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (308 aa)
ESN65452.1Hypothetical protein; KEGG: ilvM, acetolactate synthase II, small subunit. (85 aa)
ESN65453.1KEGG: acetolactate synthase 2 catalytic subunit. (555 aa)
metFKEGG: metF, 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (297 aa)
ESN62874.1Hypothetical protein; KEGG: O-succinylhomoserine (thiol)-lyase. (386 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (755 aa)
ESN63170.1KEGG: serine O-acetyltransferase. (273 aa)
ESN63222.1Phosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (376 aa)
ESN63241.1KEGG: avtA, valine--pyruvate transaminase. (418 aa)
serBKEGG: serB, phosphoserine phosphatase. (325 aa)
budAKEGG: alpha-acetolactate decarboxylase. (260 aa)
ESN63743.1KEGG: budB, acetolactate synthase, catabolic; Belongs to the TPP enzyme family. (595 aa)
cysKKEGG: cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa)
ESN63938.1KEGG: tartrate dehydrogenase. (359 aa)
ESN64177.1KEGG: D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (326 aa)
ESN64178.1Hypothetical protein; KEGG: histone acetyltransferase HPA2-like acetyltransferase. (127 aa)
ESN64248.1Hypothetical protein; KEGG: vitamin-B12 independent methionine synthase. (373 aa)
ESN64265.1Hypothetical protein; KEGG: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. (368 aa)
ESN64616.1Cysteine synthase; KEGG: cysB2, cystathionine beta-synthase. (318 aa)
serCPhosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa)
ESN65061.1Hypothetical protein; KEGG: aconitate hydratase domain-containing protein. (653 aa)
ESN65114.1KEGG: putative GAF sensor protein. (177 aa)
ESN62389.1Kynurenine--oxoglutarate transaminase; KEGG: aminotransferase. (387 aa)
ESN62456.1Aspartate transaminase; KEGG: class I/II aminotransferase. (404 aa)
pdxB4-phosphoerythronate dehydrogenase; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. (378 aa)
mnmCHypothetical protein; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the C-terminal section; belongs to the DAO family. (672 aa)
ESN62520.1Cysteine synthase; KEGG: O-acetylhomoserine/O-acetylserine sulfhydrylase. (425 aa)
cysSCysteine--tRNA ligase; KEGG: cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (461 aa)
ESN62634.1Hypothetical protein; KEGG: CoA-binding domain-containing protein. (137 aa)
ESN61403.1D-amino-acid transaminase; KEGG: class IV aminotransferase. (304 aa)
ESN61417.1Dihydroxy-acid dehydratase; KEGG: hypothetical protein; Belongs to the IlvD/Edd family. (655 aa)
ESN61477.1KEGG: ilvH, acetolactate synthase 3 regulatory subunit; overlaps another CDS with the same product name. (164 aa)
ESN61478.1KEGG: acetolactate synthase 3 catalytic subunit; overlaps another CDS with the same product name. (573 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (522 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (363 aa)
leuCHypothetical protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (466 aa)
leuDHypothetical protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa)
ilvBKEGG: acetolactate synthase, large subunit, biosynthetic type. (554 aa)
ESN61492.1Hypothetical protein; KEGG: ilvN, acetolactate synthase small subunit. (97 aa)
ESN61534.1KEGG: thrC, threonine synthase. (429 aa)
thrBHypothetical protein; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa)
ESN61536.1Hypothetical protein; KEGG: aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. (819 aa)
ESN61547.1KEGG: D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (410 aa)
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (384 aa)
ESN61596.1Glyoxylate reductase (NADP(+)); KEGG: D-isomer specific 2-hydroxyacid dehydrogenase. (308 aa)
ESN61669.1Hypothetical protein; KEGG: homocysteine S-methyltransferase. (300 aa)
ESN61381.1Aromatic-amino-acid transaminase; KEGG: aromatic amino acid aminotransferase. (397 aa)
Your Current Organism:
Serratia sp. ATCC 39006
NCBI taxonomy Id: 104623
Other names: S. sp. ATCC 39006
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