STRINGSTRING
tilS tilS ESN64235.1 ESN64235.1 queC queC purM purM purC purC asnB asnB rimK rimK ESN64994.1 ESN64994.1 ESN65046.1 ESN65046.1 nadE nadE bioD bioD pncB pncB lplA lplA ESN62228.1 ESN62228.1 bioD-2 bioD-2 ESN62480.1 ESN62480.1 ESN62558.1 ESN62558.1 purK purK ESN62681.1 ESN62681.1 guaA guaA purL purL panC panC gshA gshA ddl-2 ddl-2 murC murC murD murD murF murF murE murE carB carB carA carA gshB gshB mpl mpl purA purA epmA epmA ESN61661.1 ESN61661.1 pyrG pyrG ESN61335.1 ESN61335.1 ESN61337.1 ESN61337.1 glnA glnA coaBC coaBC uca uca argG argG gvpF1 gvpF1 birA birA purD purD ESN63396.1 ESN63396.1 accC accC ESN63600.1 ESN63600.1 ddl ddl ESN63852.1 ESN63852.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tilSHypothetical protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (421 aa)
ESN64235.1KEGG: argG2, argininosuccinate synthase. (409 aa)
queCHypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (231 aa)
purMKEGG: phosphoribosylformylglycinamidine cyclo-ligase. (345 aa)
purCKEGG: phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (237 aa)
asnBKEGG: asparagine synthase. (553 aa)
rimKHypothetical protein; KEGG: alpha-L-glutamate ligase; Belongs to the RimK family. (309 aa)
ESN64994.1Hypothetical protein; KEGG: phosphoribosylglycinamide synthetase ATP-grasp domain-containing protein. (403 aa)
ESN65046.1Hypothetical protein; KEGG: biotin carboxylase. (419 aa)
nadEHypothetical protein; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (274 aa)
bioDHypothetical protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. (221 aa)
pncBHypothetical protein; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (401 aa)
lplAHypothetical protein; Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. Belongs to the LplA family. (338 aa)
ESN62228.1Hypothetical protein; KEGG: carbamoyl-phosphate synthase small subunit. (392 aa)
bioD-2Hypothetical protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. (226 aa)
ESN62480.1Dihydrofolate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. (422 aa)
ESN62558.1Hypothetical protein; KEGG: asparagine synthase. (501 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (356 aa)
ESN62681.1KEGG: ribosomal protein S6 modification protein; Belongs to the RimK family. (290 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (525 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1294 aa)
panCHypothetical protein; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (284 aa)
gshAHypothetical protein; KEGG: gshA, gamma-glutamate-cysteine ligase; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. (517 aa)
ddl-2D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (306 aa)
murCUDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (486 aa)
murDUDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (437 aa)
murFUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (453 aa)
murEUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (495 aa)
carBKEGG: carB, carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1074 aa)
carAKEGG: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (382 aa)
gshBKEGG: gshB, glutathione synthetase; Belongs to the prokaryotic GSH synthase family. (319 aa)
mplUDP-N-acetylmuramate--L-alanine ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. (460 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)
epmALysine--tRNA ligase; With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF- P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P; Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily. (341 aa)
ESN61661.1KEGG: hypothetical protein. (479 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa)
ESN61335.1KEGG: IucA/IucC family protein. (591 aa)
ESN61337.1KEGG: IucA/IucC family protein. (570 aa)
glnAHypothetical protein; KEGG: glnA, glutamine synthetase. (469 aa)
coaBCPhosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (413 aa)
ucaKEGG: Urea carboxylase. (1208 aa)
argGKEGG: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (450 aa)
gvpF1Hypothetical protein; KEGG: gas vesicle synthesis GvpLGvpF. (272 aa)
birABiotin--(acetyl-CoA-carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. (319 aa)
purDKEGG: phosphoribosylamine--glycine ligase; Belongs to the GARS family. (428 aa)
ESN63396.1KEGG: CTP synthase. (231 aa)
accCAcetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa)
ESN63600.1Hypothetical protein; KEGG: 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (204 aa)
ddlD-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (365 aa)
ESN63852.1Hypothetical protein; KEGG: molybdenum cofactor biosynthesis protein F. (268 aa)
Your Current Organism:
Serratia sp. ATCC 39006
NCBI taxonomy Id: 104623
Other names: S. sp. ATCC 39006
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