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| | amn | AMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (490 aa) |
| | ESN62457.1 | 5'-nucleotidase; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. (199 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa) |
| | ESN62463.1 | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (712 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (505 aa) |
| | accD | Acetyl-CoA carboxylase; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (342 aa) |
| | ESN62569.1 | KEGG: cpsB, mannose-1-phosphate guanyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family. (490 aa) |
| | fcl | GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (321 aa) |
| | gmd-2 | GDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (372 aa) |
| | ESN62606.1 | Hypothetical protein; KEGG: N-formimino-L-glutamate deiminase. (453 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (288 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (169 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (356 aa) |
| | ESN62625.1 | KEGG: UspA domain-containing protein. (142 aa) |
| | ESN62627.1 | Hypothetical protein; KEGG: isochorismatase hydrolase. (197 aa) |
| | ESN62673.1 | KEGG: hypothetical protein. (411 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (525 aa) |
| | guaB | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1294 aa) |
| | ESN62768.1 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (533 aa) |
| | dgt | dGTPase; dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs; Belongs to the dGTPase family. Type 1 subfamily. (498 aa) |
| | mtnN | Adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. Belongs to the PNP/UDP [...] (233 aa) |
| | ESN62813.1 | KEGG: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (176 aa) |
| | ESN62822.1 | Hypothetical protein; KEGG: isochorismatase hydrolase. (187 aa) |
| | ESN62857.1 | Hypothetical protein; KEGG: competence damage-inducible protein A; Belongs to the CinA family. (159 aa) |
| | aceF | Dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (625 aa) |
| | aceE | Pyruvate dehydrogenase (acetyl-transferring); Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa) |
| | ESN61447.1 | Nicotinate-nucleotide diphosphorylase (carboxylating); KEGG: nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. (296 aa) |
| | guaC | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (375 aa) |
| | coaE | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (206 aa) |
| | carB | KEGG: carB, carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1074 aa) |
| | carA | KEGG: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (382 aa) |
| | ESN61521.1 | KEGG: bifunctional riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. (313 aa) |
| | gpmB | KEGG: phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. GpmB subfamily. (216 aa) |
| | yjjX | Hypothetical protein; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. (179 aa) |
| | ESN61558.1 | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (358 aa) |
| | pgk | KEGG: phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (387 aa) |
| | ESN61569.1 | KEGG: hypothetical protein; Belongs to the UPF0301 (AlgH) family. (187 aa) |
| | queA | Hypothetical protein; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (355 aa) |
| | tgt | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (385 aa) |
| | queC | Hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (231 aa) |
| | ESN64313.1 | Choloyl-CoA hydrolase; KEGG: acyl-CoA thioesterase II. (287 aa) |
| | apt | Hypothetical protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (182 aa) |
| | adk | Hypothetical protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (235 aa) |
| | ESN64344.1 | KEGG: nrdB, ribonucleotide-diphosphate reductase subunit beta. (376 aa) |
| | ESN64359.1 | Hypothetical protein; KEGG: competence/damage-inducible protein CinA; Belongs to the CinA family. (397 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (212 aa) |
| | purM | KEGG: phosphoribosylformylglycinamidine cyclo-ligase. (345 aa) |
| | upp | Hypothetical protein; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa) |
| | pyrH | UMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (243 aa) |
| | purC | KEGG: phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (237 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (219 aa) |
| | accA | Acetyl-CoA carboxylase; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | ESN64213.1 | Hypothetical protein; KEGG: Glyoxalase/bleomycin resistance protein/dioxygenase. (129 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | ESN63941.1 | Hypothetical protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (289 aa) |
| | queF | PreQ(1) synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). (280 aa) |
| | ESN61352.1 | Hypothetical protein; KEGG: amidohydrolase. (426 aa) |
| | ESN61349.1 | KEGG: chlorohydrolase/deaminase family protein. (472 aa) |
| | uraH | Hypothetical protein; KEGG: hydroxyisourate hydrolase; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (110 aa) |
| | uraD | Hypothetical protein; KEGG: OHCU decarboxylase. (166 aa) |
| | ESN61338.1 | KEGG: siderophore biosynthesis protein. (388 aa) |
| | ESN61317.1 | Hypothetical protein; KEGG: N-acetyltransferase GCN5. (151 aa) |
| | rdgB-2 | Nucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (197 aa) |
| | ESN61308.1 | KEGG: codA, cytosine deaminase. (412 aa) |
| | hldE | Hypothetical protein; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (475 aa) |
| | ESN61251.1 | GTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (744 aa) |
| | ESN61250.1 | Hypothetical protein; KEGG: mazG, nucleoside triphosphate pyrophosphohydrolase. (264 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) |
| | eno-2 | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (433 aa) |
| | queE | Hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (223 aa) |
| | queD | Hypothetical protein; KEGG: 6-pyruvoyl tetrahydropterin synthase. (125 aa) |
| | ESN61219.1 | Hypothetical protein; KEGG: D,D-heptose 1,7-bisphosphate phosphatase. (188 aa) |
| | gpt | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (152 aa) |
| | ESN61671.1 | Hypothetical protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (154 aa) |
| | ESN61660.1 | Hypothetical protein; KEGG: endoribonuclease L-PSP. (128 aa) |
| | pyrI | Hypothetical protein; Involved in allosteric regulation of aspartate carbamoyltransferase. (156 aa) |
| | pyrB | KEGG: pyrB, aspartate carbamoyltransferase catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (311 aa) |
| | queG | Hypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (379 aa) |
| | nnrD | Hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epi [...] (508 aa) |
| | purA | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa) |
| | pgi | KEGG: pgi, glucose-6-phosphate isomerase; Belongs to the GPI family. (550 aa) |
| | ESN63894.1 | Hypothetical protein; KEGG: NUDIX hydrolase. (193 aa) |
| | nadK | Hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (292 aa) |
| | ESN63852.1 | Hypothetical protein; KEGG: molybdenum cofactor biosynthesis protein F. (268 aa) |
| | mmsA | Methylmalonate-semialdehyde dehydrogenase (acylating); KEGG: aldehyde dehydrogenase. (503 aa) |
| | ESN63811.1 | KEGG: hypothetical protein. (119 aa) |
| | acs | Acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (652 aa) |
| | ESN63797.1 | Hypothetical protein; KEGG: NAD-dependent epimerase/dehydratase. (296 aa) |
| | gmd | GDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (344 aa) |
| | ESN63774.1 | KEGG: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Belongs to the mannose-6-phosphate isomerase type 2 family. (476 aa) |
| | rfbC | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (186 aa) |
| | rfbD | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (290 aa) |
| | rfbB | KEGG: rfbB, dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (355 aa) |
| | ESN63750.1 | KEGG: hypothetical protein. (202 aa) |
| | deoD | KEGG: purine nucleoside phosphorylase. (239 aa) |
| | deoB | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (407 aa) |
| | deoA | Thymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (447 aa) |
| | ESN63725.1 | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. (250 aa) |
| | lsrF | Hypothetical protein; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5- phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA; Belongs to the DeoC/FbaB aldolase family. (291 aa) |
| | ESN63628.1 | KEGG: acoX, acetoin catabolism protein X, ATP-NAD kinase AcoX. (359 aa) |
| | ESN63624.1 | Hypothetical protein; KEGG: anaerobic sulfite reductase subunit B. (272 aa) |
| | ESN63601.1 | Hypothetical protein; KEGG: nadR, NadR transcriptional repressor/ribosylnicotinamide kinase/NMN adenylyltransferase. (413 aa) |
| | sgbH | KEGG: sgbH, 3-keto-L-gulonate-6-phosphate decarboxylase. (216 aa) |
| | ESN63544.1 | KEGG: 5'-nucleotidase. (319 aa) |
| | ESN63512.1 | KEGG: nudF, ADP-ribose pyrophosphatase NudF. (210 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (420 aa) |
| | ESN63451.1 | Hypothetical protein; KEGG: NUDIX hydrolase. (184 aa) |
| | ulaD | KEGG: 3-keto-L-gulonate-6-phosphate decarboxylase UlaD (L-ascorbate utilization protein D). (217 aa) |
| | ESN63415.1 | Hypothetical protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (197 aa) |
| | accC | Acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa) |
| | ESN63396.1 | KEGG: CTP synthase. (231 aa) |
| | purH | KEGG: purH, phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. (529 aa) |
| | purD | KEGG: phosphoribosylamine--glycine ligase; Belongs to the GARS family. (428 aa) |
| | nudC | NAD(+) diphosphatase; KEGG: nudC, NADH pyrophosphatase; Belongs to the Nudix hydrolase family. NudC subfamily. (257 aa) |
| | coaA | KEGG: pantothenate kinase. (316 aa) |
| | ESN63276.1 | Hypothetical protein; KEGG: isochorismatase hydrolase. (183 aa) |
| | hydA | Dihydropyrimidinase; KEGG: phenylhydantoinase. (483 aa) |
| | ESN63238.1 | KEGG: dihydropyrimidine dehydrogenase; overlaps another CDS with the same product name. (437 aa) |
| | ESN63237.1 | Dihydropyrimidine dehydrogenase (NADP(+)); KEGG: gltD, glutamate synthase subunit beta; overlaps another CDS with the same product name. (472 aa) |
| | glk | KEGG: glk, glucokinase; Belongs to the bacterial glucokinase family. (322 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa) |
| | dut | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (152 aa) |
| | coaBC | Phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (413 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa) |
| | hldD | ADP-glyceromanno-heptose 6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (310 aa) |
| | ESN63156.1 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (254 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (207 aa) |
| | ESN63122.1 | Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (700 aa) |
| | ESN63117.1 | Hypothetical protein; KEGG: yiiD, acetyltransferase. (313 aa) |
| | atpB | Hypothetical protein; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (260 aa) |
| | atpE | Hypothetical protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (79 aa) |
| | atpF | Hypothetical protein; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (156 aa) |
| | atpH | Hypothetical protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (177 aa) |
| | atpA | Hypothetical protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (513 aa) |
| | atpG | Hypothetical protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (287 aa) |
| | atpD | Hypothetical protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (460 aa) |
| | atpC | Hypothetical protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. (140 aa) |
| | glmU | Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (456 aa) |
| | glmS | Glutamine--fructose-6-phosphate transaminase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (611 aa) |
| | ESN63067.1 | KEGG: AMP-binding protein. (450 aa) |
| | bcsA | Hypothetical protein; Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose. (706 aa) |
| | ESN62945.1 | KEGG: hypothetical protein. (187 aa) |
| | ESN62944.1 | Hypothetical protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (225 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa) |
| | tpiA | Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa) |
| | gppA | Guanosine-5'-triphosphate,3'-diphosphate diphosphatase; Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. (498 aa) |
| | ESN65425.1 | KEGG: mtaD, 5-methylthioadenosine/s-adenosylhomocysteine deaminase. (441 aa) |
| | ESN65419.1 | KEGG: thymidylate synthase protein. (327 aa) |
| | rdgB | Nucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (200 aa) |
| | ESN65387.1 | KEGG: cyaA, adenylate cyclase; Belongs to the adenylyl cyclase class-1 family. (851 aa) |
| | ESN64427.1 | Hypothetical protein; KEGG: corC, Magnesium and cobalt efflux protein CorC. (292 aa) |
| | ESN64464.1 | Dihydrolipoyllysine-residue succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (409 aa) |
| | nadA | Quinolinate synthase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (347 aa) |
| | gpmA | Bisphosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (250 aa) |
| | udk | KEGG: uridine kinase. (227 aa) |
| | dcd | Hypothetical protein; Catalyzes the deamination of dCTP to dUTP. (193 aa) |
| | ESN64510.1 | KEGG: ugd, UDP-glucose dehydrogenase. (388 aa) |
| | ESN64511.1 | KEGG: UTP--glucose-1-phosphate uridylyltransferase. (301 aa) |
| | ESN64561.1 | Ribosylpyrimidine nucleosidase; KEGG: Inosine-uridine preferring nucleoside hydrolase; Belongs to the IUNH family. (317 aa) |
| | ESN64562.1 | Hypothetical protein; KEGG: Inosine/uridine-preferring nucleoside hydrolase; Belongs to the IUNH family. (316 aa) |
| | ESN64583.1 | Hypothetical protein; KEGG: putative endoribonuclease. (127 aa) |
| | phnN | Hypothetical protein; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). (177 aa) |
| | queH | Hypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (189 aa) |
| | ESN64859.1 | KEGG: hypothetical protein. (245 aa) |
| | ESN64876.1 | Hypothetical protein; KEGG: grxA, glutaredoxin. (87 aa) |
| | cmk | KEGG: cytidylate kinase. (225 aa) |
| | citD | Hypothetical protein; Covalent carrier of the coenzyme of citrate lyase. (97 aa) |
| | citF | KEGG: citF, citrate lyase subunit alpha. (509 aa) |
| | kdsB | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (250 aa) |
| | ESN64993.1 | Hypothetical protein; KEGG: putative biotin carboxylase. (387 aa) |
| | ESN64994.1 | Hypothetical protein; KEGG: phosphoribosylglycinamide synthetase ATP-grasp domain-containing protein. (403 aa) |
| | pyk | KEGG: pyruvate kinase; Belongs to the pyruvate kinase family. (480 aa) |
| | purT | Phosphoribosylaminoimidazole carboxylase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (392 aa) |
| | ESN65065.1 | Hypothetical protein; KEGG: isochorismatase hydrolase. (204 aa) |
| | guaD | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (452 aa) |
| | ESN65084.1 | KEGG: hypothetical protein. (450 aa) |
| | ESN65125.1 | KEGG: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa) |
| | ESN65145.1 | KEGG: ygbA, hypothetical protein. (118 aa) |
| | nadE | Hypothetical protein; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (274 aa) |
| | ESN65172.1 | Hypothetical protein; KEGG: yeaB, NUDIX hydrolase; Belongs to the Nudix hydrolase family. PCD1 subfamily. (203 aa) |
| | ESN61742.1 | KEGG: gapA, glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa) |
| | ESN61745.1 | KEGG: pncA, nicotinamidase/pyrazinamidase. (212 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (282 aa) |
| | galU | KEGG: UTP-glucose-1-phosphate uridylyltransferase. (300 aa) |
| | ESN61773.1 | Hypothetical protein; KEGG: acyl-CoA thioester hydrolase. (142 aa) |
| | atpD-2 | Hypothetical protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (476 aa) |
| | ESN61812.1 | Hypothetical protein; KEGG: H+-transporting two-sector ATPase subunit delta/epsilon. (134 aa) |
| | atpB-2 | Hypothetical protein; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (233 aa) |
| | atpE-2 | Hypothetical protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (93 aa) |
| | atpF-2 | Hypothetical protein; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (267 aa) |
| | atpA-2 | Hypothetical protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (515 aa) |
| | ESN61819.1 | Hypothetical protein; KEGG: H+-transporting two-sector ATPase subunit gamma. (292 aa) |
| | add | KEGG: adenosine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (337 aa) |
| | ESN61823.1 | KEGG: mannose-6-phosphate isomerase, class I; Belongs to the mannose-6-phosphate isomerase type 1 family. (394 aa) |
| | ESN61842.1 | KEGG: hypothetical protein. (784 aa) |
| | prs | Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa) |
| | ESN61912.1 | KEGG: hypothetical protein. (380 aa) |
| | ESN61954.1 | KEGG: hypothetical protein; Belongs to the UPF0267 family. (130 aa) |
| | ESN61990.1 | KEGG: type III secretion apparatus H+-transporting two-sector ATPase. (460 aa) |
| | ESN62017.1 | Hypothetical protein; KEGG: malonate decarboxylase, beta subunit. (278 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (244 aa) |
| | purR | Hypothetical protein; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. (341 aa) |
| | ESN62118.1 | KEGG: pyruvate kinase; Belongs to the pyruvate kinase family. (470 aa) |
| | pyrD | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (335 aa) |
| | pncB | Hypothetical protein; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (401 aa) |
| | ESN62182.1 | KEGG: malate/L-lactate dehydrogenase; Belongs to the LDH2/MDH2 oxidoreductase family. (353 aa) |
| | tmk | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (217 aa) |
| | ESN62197.1 | Hypothetical protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes 7- methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids; Belongs to the Maf family. YceF subfamily. (194 aa) |
| | ESN62201.1 | Dihydroorotase; KEGG: pyrC, dihydro-orotase. (375 aa) |
| | ESN62228.1 | Hypothetical protein; KEGG: carbamoyl-phosphate synthase small subunit. (392 aa) |
| | fliI | KEGG: hypothetical protein. (460 aa) |
| | citF-2 | KEGG: citrate lyase subunit alpha. (507 aa) |
| | citD-2 | Hypothetical protein; Covalent carrier of the coenzyme of citrate lyase. (97 aa) |
| | cdd | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (295 aa) |
| | ESN62309.1 | KEGG: thioesterase superfamily protein. (131 aa) |
| | eno | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (428 aa) |
