STRINGSTRING
ileS ileS cysD cysD cysH cysH hldE hldE nadE nadE argS argS metG metG ESN64453.1 ESN64453.1 ESN64447.1 ESN64447.1 glnS glnS gluQ gluQ gltX gltX guaA guaA ESN62625.1 ESN62625.1 cysS cysS ESN62563.1 ESN62563.1 ESN62558.1 ESN62558.1 ESN62347.1 ESN62347.1 ESN62330.1 ESN62330.1 ESN62329.1 ESN62329.1 citC-2 citC-2 tyrS tyrS ttcA ttcA mnmA mnmA ESN63148.1 ESN63148.1 coaD coaD argG argG trpS trpS valS valS ESN63601.1 ESN63601.1 tilS tilS ESN64235.1 ESN64235.1 thiI thiI queC queC nadD nadD leuS leuS asnB asnB ESN64965.1 ESN64965.1 citC citC panC panC ESN61521.1 ESN61521.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ileSIsoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (937 aa)
cysDKEGG: sulfate adenylyltransferase subunit 2. (302 aa)
cysHPhosphoadenylyl-sulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (244 aa)
hldEHypothetical protein; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (475 aa)
nadEHypothetical protein; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (274 aa)
argSArginine--tRNA ligase; KEGG: arginyl-tRNA synthetase. (576 aa)
metGMethionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (676 aa)
ESN64453.1KEGG: Deoxyribodipyrimidine photo-lyase; Belongs to the DNA photolyase family. (480 aa)
ESN64447.1KEGG: sensor protein KdpD. (909 aa)
glnSGlutamine--tRNA ligase; KEGG: glutaminyl-tRNA synthetase. (552 aa)
gluQHypothetical protein; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. (302 aa)
gltXGlutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (471 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (525 aa)
ESN62625.1KEGG: UspA domain-containing protein. (142 aa)
cysSCysteine--tRNA ligase; KEGG: cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (461 aa)
ESN62563.1KEGG: DUF218 domain protein. (258 aa)
ESN62558.1Hypothetical protein; KEGG: asparagine synthase. (501 aa)
ESN62347.1KEGG: universal stress protein A. (141 aa)
ESN62330.1KEGG: Electron transfer flavoprotein alpha/beta-subunit. (254 aa)
ESN62329.1KEGG: electron transfer flavoprotein subunit YdiR. (317 aa)
citC-2(Citrate (pro-3S)-lyase) ligase; Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A) of the gamma subunit of citrate lyase. (341 aa)
tyrSTyrosine--tRNA ligase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (425 aa)
ttcAHypothetical protein; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. (314 aa)
mnmAHypothetical protein; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs; Belongs to the MnmA/TRMU family. (370 aa)
ESN63148.1KEGG: UspA domain-containing protein. (145 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa)
argGKEGG: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (450 aa)
trpSTryptophan--tRNA ligase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (334 aa)
valSValine--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (951 aa)
ESN63601.1Hypothetical protein; KEGG: nadR, NadR transcriptional repressor/ribosylnicotinamide kinase/NMN adenylyltransferase. (413 aa)
tilSHypothetical protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (421 aa)
ESN64235.1KEGG: argG2, argininosuccinate synthase. (409 aa)
thiIHypothetical protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (482 aa)
queCHypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (231 aa)
nadDNicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (219 aa)
leuSValine--tRNA ligase, Leucine--tRNA ligase; KEGG: leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (860 aa)
asnBKEGG: asparagine synthase. (553 aa)
ESN64965.1KEGG: hypothetical protein. (264 aa)
citC(Citrate (pro-3S)-lyase) ligase; Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A) of the gamma subunit of citrate lyase. (348 aa)
panCHypothetical protein; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (284 aa)
ESN61521.1KEGG: bifunctional riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. (313 aa)
Your Current Organism:
Serratia sp. ATCC 39006
NCBI taxonomy Id: 104623
Other names: S. sp. ATCC 39006
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