STRINGSTRING
ESN61347.1 ESN61347.1 ESN61189.1 ESN61189.1 ESN61631.1 ESN61631.1 ESN61587.1 ESN61587.1 pgi pgi ESN61444.1 ESN61444.1 ESN61424.1 ESN61424.1 ESN62778.1 ESN62778.1 ESN62777.1 ESN62777.1 murQ murQ ESN62573.1 ESN62573.1 gmd-2 gmd-2 fcl fcl ESN62569.1 ESN62569.1 ESN62568.1 ESN62568.1 ESN62354.1 ESN62354.1 ESN62349.1 ESN62349.1 ESN62183.1 ESN62183.1 nagZ nagZ nagK nagK ESN61966.1 ESN61966.1 ESN61874.1 ESN61874.1 ESN61830.1 ESN61830.1 ESN61825.1 ESN61825.1 ESN61823.1 ESN61823.1 galU galU ESN65169.1 ESN65169.1 ESN65168.1 ESN65168.1 ESN65167.1 ESN65167.1 ESN64958.1 ESN64958.1 ESN64536.1 ESN64536.1 ESN64511.1 ESN64511.1 ESN64510.1 ESN64510.1 ESN64509.1 ESN64509.1 galE galE ESN64491.1 ESN64491.1 galK galK ESN64444.1 ESN64444.1 ESN64436.1 ESN64436.1 ESN62910.1 ESN62910.1 arnD arnD arnA arnA arnC arnC arnB arnB murB murB glmS glmS glmU glmU glk glk nagB nagB ESN64434.1 ESN64434.1 ESN64433.1 ESN64433.1 ESN64268.1 ESN64268.1 ESN64098.1 ESN64098.1 ESN63906.1 ESN63906.1 ESN63840.1 ESN63840.1 ESN63797.1 ESN63797.1 gmd gmd rfbF rfbF rfbG rfbG ESN63775.1 ESN63775.1 ESN63774.1 ESN63774.1 xerD xerD glmM glmM murA murA rapZ rapZ msrQ msrQ ESN63391.1 ESN63391.1 ESN65199.1 ESN65199.1 ESN65225.1 ESN65225.1 glgC glgC ESN65410.1 ESN65410.1 wecC wecC wecB wecB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ESN61347.1Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (187 aa)
ESN61189.1KEGG: RpiR family transcriptional regulator. (279 aa)
ESN61631.1Hypothetical protein; KEGG: putative phosphosugar isomerase. (324 aa)
ESN61587.1KEGG: hypothetical protein. (160 aa)
pgiKEGG: pgi, glucose-6-phosphate isomerase; Belongs to the GPI family. (550 aa)
ESN61444.1Alpha-N-arabinofuranosidase; KEGG: Alpha-L-arabinofuranosidase II precursor; Belongs to the glycosyl hydrolase 43 family. (316 aa)
ESN61424.1KEGG: ROK family protein. (308 aa)
ESN62778.1KEGG: ROK family protein. (372 aa)
ESN62777.1Hypothetical protein; KEGG: N-acetylglucosamine kinase. (286 aa)
murQHypothetical protein; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily. (297 aa)
ESN62573.1Hypothetical protein; KEGG: transferase. (179 aa)
gmd-2GDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (372 aa)
fclGDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (321 aa)
ESN62569.1KEGG: cpsB, mannose-1-phosphate guanyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family. (490 aa)
ESN62568.1KEGG: manB, phosphomannomutase. (457 aa)
ESN62354.1KEGG: arabinogalactan endo-1,4-beta-galactosidase. (400 aa)
ESN62349.1Hypothetical protein; KEGG: putative cyclic beta 1-2 glucan synthetase. (2865 aa)
ESN62183.1Protein-N(pi)-phosphohistidine--sugar phosphotransferase; KEGG: ptsG, PTS system glucose-specific transporter subunits IIBC. (477 aa)
nagZHypothetical protein; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. (342 aa)
nagKN-acetylglucosamine kinase; Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. (304 aa)
ESN61966.1Hypothetical protein; KEGG: xerC, site-specific tyrosine recombinase XerC; Belongs to the 'phage' integrase family. (364 aa)
ESN61874.1KEGG: ROK family protein. (385 aa)
ESN61830.1KEGG: ROK family protein. (405 aa)
ESN61825.1Hypothetical protein; KEGG: transcriptional regulator/sugar kinase. (332 aa)
ESN61823.1KEGG: mannose-6-phosphate isomerase, class I; Belongs to the mannose-6-phosphate isomerase type 1 family. (394 aa)
galUKEGG: UTP-glucose-1-phosphate uridylyltransferase. (300 aa)
ESN65169.1Protein-N(pi)-phosphohistidine--sugar phosphotransferase; KEGG: PTS system mannose/fructose/sorbose family transporter subunit IIB. (320 aa)
ESN65168.1Hypothetical protein; KEGG: PTS system mannose/fructose/sorbose family transporter subunit IIC. (266 aa)
ESN65167.1Hypothetical protein; KEGG: PTS system mannose-specific transporter subunit IID. (280 aa)
ESN64958.1Hypothetical protein; KEGG: DNA internalization-like competence protein ComEC/Rec2. (721 aa)
ESN64536.1KEGG: RpiR family transcriptional regulator. (291 aa)
ESN64511.1KEGG: UTP--glucose-1-phosphate uridylyltransferase. (301 aa)
ESN64510.1KEGG: ugd, UDP-glucose dehydrogenase. (388 aa)
ESN64509.1UDP-glucuronate 5'-epimerase; KEGG: NAD-dependent epimerase/dehydratase. (335 aa)
galEKEGG: UDP-galactose-4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (338 aa)
ESN64491.1KEGG: galactose-1-phosphate uridylyltransferase. (348 aa)
galKGalactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily. (383 aa)
ESN64444.1Hypothetical protein; KEGG: phosphoglucomutase. (547 aa)
ESN64436.1Protein-N(pi)-phosphohistidine--sugar phosphotransferase; KEGG: nagE, PTS system N-acetylglucosamine-specific transporter subunit IIABC. (482 aa)
ESN62910.1KEGG: hypothetical protein. (253 aa)
arnDHypothetical protein; Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily. (300 aa)
arnAMethionyl-tRNA formyltransferase, UDP-glucuronate decarboxylase; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the N-terminal section; belongs to the Fmt family. UDP- L-Ara4N formyltransferase subfamily. (660 aa)
arnCHypothetical protein; Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. (327 aa)
arnBGlutamine--scyllo-inositol transaminase; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. (384 aa)
murBUDP-N-acetylmuramate dehydrogenase; Cell wall formation. (344 aa)
glmSGlutamine--fructose-6-phosphate transaminase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (611 aa)
glmUGlucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (456 aa)
glkKEGG: glk, glucokinase; Belongs to the bacterial glucokinase family. (322 aa)
nagBGlucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (266 aa)
ESN64434.1KEGG: N-acetylglucosamine-6-phosphate deacetylase. (384 aa)
ESN64433.1Glucokinase; KEGG: ROK family protein. (407 aa)
ESN64268.1Peroxiredoxin; KEGG: ahpC, putative alkyl hydroperoxide reductase subunit c. (200 aa)
ESN64098.1KEGG: hypothetical protein. (507 aa)
ESN63906.1Hypothetical protein; KEGG: PTS system glucose-specific transporter. (169 aa)
ESN63840.1KEGG: RpiR family transcriptional regulator. (286 aa)
ESN63797.1Hypothetical protein; KEGG: NAD-dependent epimerase/dehydratase. (296 aa)
gmdGDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (344 aa)
rfbFKEGG: rfbF, glucose-1-phosphate cytidylyltransferase. (258 aa)
rfbGCDP-glucose 4,6-dehydratase; KEGG: h16_A2896, NAD dependent sugar epimerase. (360 aa)
ESN63775.1KEGG: phosphomannomutase. (453 aa)
ESN63774.1KEGG: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Belongs to the mannose-6-phosphate isomerase type 2 family. (476 aa)
xerDHypothetical protein; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerC binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. In the complex XerD specifically exchanges the bo [...] (299 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (445 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (420 aa)
rapZHypothetical protein; Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6- phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS; Belongs to the RapZ-like family. RapZ subfamily. (284 aa)
msrQHypothetical protein; Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the [...] (199 aa)
ESN63391.1Hypothetical protein; KEGG: transcriptional regulator/sugar kinase. (100 aa)
ESN65199.1Fructokinase; KEGG: PfkB domain-containing protein; Belongs to the carbohydrate kinase PfkB family. (311 aa)
ESN65225.1Hypothetical protein; KEGG: DNA topoisomerase. (186 aa)
glgCGlucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (427 aa)
ESN65410.1Hypothetical protein; KEGG: acbM, 2-epi-5-epi-valiolone 7-kinase. (346 aa)
wecCUDP-glucose 6-dehydrogenase; Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA); Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily. (420 aa)
wecBUDP-N-acetylglucosamine 2-epimerase; Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP- N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues. (361 aa)
Your Current Organism:
Serratia sp. ATCC 39006
NCBI taxonomy Id: 104623
Other names: S. sp. ATCC 39006
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