(19 nodes) C5-Branched dibasic acid metabolism network (Serratia sp. ATCC 39006)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	ESN65300.1	KEGG: MmgE/PrpD family protein. (452 aa)
	ilvB	KEGG: acetolactate synthase, large subunit, biosynthetic type. (554 aa)
	ESN61492.1	Hypothetical protein; KEGG: ilvN, acetolactate synthase small subunit. (97 aa)
	sucD	Succinate--CoA ligase (ADP-forming); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
	sucC	Succinate--CoA ligase (ADP-forming); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
	ligK	Hypothetical protein; KEGG: 4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase. (239 aa)
	ESN63938.1	KEGG: tartrate dehydrogenase. (359 aa)
	ESN63743.1	KEGG: budB, acetolactate synthase, catabolic; Belongs to the TPP enzyme family. (595 aa)
	budA	KEGG: alpha-acetolactate decarboxylase. (260 aa)
	rraA	Hypothetical protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome. (161 aa)
	ESN65453.1	KEGG: acetolactate synthase 2 catalytic subunit. (555 aa)
	ESN61193.1	KEGG: hypothetical protein. (127 aa)
	ESN65452.1	Hypothetical protein; KEGG: ilvM, acetolactate synthase II, small subunit. (85 aa)
	leuB	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (363 aa)
	leuC	Hypothetical protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (466 aa)
	leuD	Hypothetical protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa)
	ESN65061.1	Hypothetical protein; KEGG: aconitate hydratase domain-containing protein. (653 aa)
	ESN61478.1	KEGG: acetolactate synthase 3 catalytic subunit; overlaps another CDS with the same product name. (573 aa)
	ESN61477.1	KEGG: ilvH, acetolactate synthase 3 regulatory subunit; overlaps another CDS with the same product name. (164 aa)

Your Current Organism:

Serratia sp. ATCC 39006

NCBI taxonomy Id: 104623
Other names: S. sp. ATCC 39006

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ESN61193.1	ESN63938.1	Ser39006_04221	Ser39006_01346	KEGG: hypothetical protein.	KEGG: tartrate dehydrogenase.	0.569
ESN61193.1	ESN65061.1	Ser39006_04221	Ser39006_02469	KEGG: hypothetical protein.	Hypothetical protein; KEGG: aconitate hydratase domain-containing protein.	0.421
ESN61193.1	ESN65300.1	Ser39006_04221	Ser39006_00111	KEGG: hypothetical protein.	KEGG: MmgE/PrpD family protein.	0.606
ESN61193.1	leuB	Ser39006_04221	Ser39006_03888	KEGG: hypothetical protein.	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	0.511
ESN61193.1	sucC	Ser39006_04221	Ser39006_01873	KEGG: hypothetical protein.	Succinate--CoA ligase (ADP-forming); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.996
ESN61477.1	ESN61478.1	Ser39006_03884	Ser39006_03885	KEGG: ilvH, acetolactate synthase 3 regulatory subunit; overlaps another CDS with the same product name.	KEGG: acetolactate synthase 3 catalytic subunit; overlaps another CDS with the same product name.	0.996
ESN61477.1	ESN61492.1	Ser39006_03884	Ser39006_03899	KEGG: ilvH, acetolactate synthase 3 regulatory subunit; overlaps another CDS with the same product name.	Hypothetical protein; KEGG: ilvN, acetolactate synthase small subunit.	0.680
ESN61477.1	ESN63743.1	Ser39006_03884	Ser39006_01151	KEGG: ilvH, acetolactate synthase 3 regulatory subunit; overlaps another CDS with the same product name.	KEGG: budB, acetolactate synthase, catabolic; Belongs to the TPP enzyme family.	0.957
ESN61477.1	ESN63938.1	Ser39006_03884	Ser39006_01346	KEGG: ilvH, acetolactate synthase 3 regulatory subunit; overlaps another CDS with the same product name.	KEGG: tartrate dehydrogenase.	0.874
ESN61477.1	ESN65061.1	Ser39006_03884	Ser39006_02469	KEGG: ilvH, acetolactate synthase 3 regulatory subunit; overlaps another CDS with the same product name.	Hypothetical protein; KEGG: aconitate hydratase domain-containing protein.	0.966
ESN61477.1	ESN65452.1	Ser39006_03884	Ser39006_00263	KEGG: ilvH, acetolactate synthase 3 regulatory subunit; overlaps another CDS with the same product name.	Hypothetical protein; KEGG: ilvM, acetolactate synthase II, small subunit.	0.692
ESN61477.1	ESN65453.1	Ser39006_03884	Ser39006_00264	KEGG: ilvH, acetolactate synthase 3 regulatory subunit; overlaps another CDS with the same product name.	KEGG: acetolactate synthase 2 catalytic subunit.	0.982
ESN61477.1	budA	Ser39006_03884	Ser39006_01150	KEGG: ilvH, acetolactate synthase 3 regulatory subunit; overlaps another CDS with the same product name.	KEGG: alpha-acetolactate decarboxylase.	0.824
ESN61477.1	ilvB	Ser39006_03884	Ser39006_03898	KEGG: ilvH, acetolactate synthase 3 regulatory subunit; overlaps another CDS with the same product name.	KEGG: acetolactate synthase, large subunit, biosynthetic type.	0.983
ESN61477.1	leuB	Ser39006_03884	Ser39006_03888	KEGG: ilvH, acetolactate synthase 3 regulatory subunit; overlaps another CDS with the same product name.	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	0.953
ESN61477.1	leuC	Ser39006_03884	Ser39006_03889	KEGG: ilvH, acetolactate synthase 3 regulatory subunit; overlaps another CDS with the same product name.	Hypothetical protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.	0.847
ESN61477.1	leuD	Ser39006_03884	Ser39006_03890	KEGG: ilvH, acetolactate synthase 3 regulatory subunit; overlaps another CDS with the same product name.	Hypothetical protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.	0.905
ESN61478.1	ESN61477.1	Ser39006_03885	Ser39006_03884	KEGG: acetolactate synthase 3 catalytic subunit; overlaps another CDS with the same product name.	KEGG: ilvH, acetolactate synthase 3 regulatory subunit; overlaps another CDS with the same product name.	0.996
ESN61478.1	ESN61492.1	Ser39006_03885	Ser39006_03899	KEGG: acetolactate synthase 3 catalytic subunit; overlaps another CDS with the same product name.	Hypothetical protein; KEGG: ilvN, acetolactate synthase small subunit.	0.934
ESN61478.1	ESN63743.1	Ser39006_03885	Ser39006_01151	KEGG: acetolactate synthase 3 catalytic subunit; overlaps another CDS with the same product name.	KEGG: budB, acetolactate synthase, catabolic; Belongs to the TPP enzyme family.	0.706