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sfcA sfcA leuA leuA icd icd lpd lpd aceF aceF pdhB pdhB pdhA pdhA fumA fumA gltA gltA gabD gabD pdhA-2 pdhA-2 bkdA2 bkdA2 aceF-2 aceF-2 leuA-2 leuA-2 pdhA-3 pdhA-3 pdhB-2 pdhB-2 acnA acnA sucC sucC sucD sucD TC41_1398 TC41_1398 icd-2 icd-2 TC41_1526 TC41_1526 TC41_1774 TC41_1774 sdhB sdhB sdhA sdhA sdhC sdhC fdxA fdxA sfcA-2 sfcA-2 mqo mqo sucB sucB sucA sucA gltA-2 gltA-2 leuD leuD leuC leuC leuB leuB ilvC ilvC ilvH ilvH ilvB ilvB ilvD ilvD ilvE ilvE mdh mdh icd-3 icd-3 pyk pyk dld dld TC41_2842 TC41_2842
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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sfcAMalate dehydrogenase (oxaloacetate- decarboxylating). (503 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (574 aa)
icdIsocitrate/isopropylmalate dehydrogenase. (365 aa)
lpdDihydrolipoamide dehydrogenase. (470 aa)
aceFDihydrolipoyllysine-residue succinyltransferase. (435 aa)
pdhBTransketolase central region. (326 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (361 aa)
fumAHydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (508 aa)
gltACitrate (Si)-synthase; Belongs to the citrate synthase family. (359 aa)
gabDAldehyde Dehydrogenase; Belongs to the aldehyde dehydrogenase family. (492 aa)
pdhA-2Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (370 aa)
bkdA2Transketolase central region. (324 aa)
aceF-2Dihydrolipoyllysine-residue succinyltransferase. (442 aa)
leuA-22-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (533 aa)
pdhA-3Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (358 aa)
pdhB-2Transketolase central region. (325 aa)
acnAAconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (904 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (398 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (299 aa)
TC41_1398Glu/Leu/Phe/Val dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (364 aa)
icd-2Isocitrate dehydrogenase. (487 aa)
TC41_1526FAD dependent oxidoreductase. (421 aa)
TC41_1774Hypothetical protein. (184 aa)
sdhBSuccinate dehydrogenase and fumarate reductase iron-sulfur protein. (262 aa)
sdhASuccinate dehydrogenase or fumarate reductase, flavoprotein subunit. (596 aa)
sdhCSuccinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family. (206 aa)
fdxA4Fe-4S ferredoxin iron-sulfur binding domain protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (79 aa)
sfcA-2Malate dehydrogenase (oxaloacetate- decarboxylating). (474 aa)
mqoMalate/quinone oxidoreductase. (548 aa)
sucB2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase. (419 aa)
sucA2-oxoglutarate dehydrogenase, E1 subunit. (949 aa)
gltA-22-methylcitrate synthase/citrate synthase II; Belongs to the citrate synthase family. (377 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (202 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (471 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (359 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (350 aa)
ilvHAcetolactate synthase, small subunit. (176 aa)
ilvBAcetolactate synthase, large subunit, biosynthetic type. (576 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (557 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (295 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (311 aa)
icd-3Isocitrate dehydrogenase, NADP-dependent. (432 aa)
pykPyruvate kinase; Belongs to the pyruvate kinase family. (472 aa)
dldD-lactate dehydrogenase (cytochrome). (461 aa)
TC41_2842Cyclase family protein. (216 aa)
Your Current Organism:
Alicyclobacillus acidocaldarius Tc41
NCBI taxonomy Id: 1048834
Other names: A. acidocaldarius subsp. acidocaldarius Tc-4-1, Alicyclobacillus acidocaldarius subsp. acidocaldarius Tc-4-1, Alicyclobacillus acidocaldarius subsp. acidocaldarius str. Tc-4-1, Alicyclobacillus acidocaldarius subsp. acidocaldarius strain Tc-4-1
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