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leuD leuD leuC leuC leuB leuB ilvC ilvC ilvH ilvH ilvB ilvB ilvD ilvD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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Your Input:
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (202 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (471 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (359 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (350 aa)
ilvHAcetolactate synthase, small subunit. (176 aa)
ilvBAcetolactate synthase, large subunit, biosynthetic type. (576 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (557 aa)
Your Current Organism:
Alicyclobacillus acidocaldarius Tc41
NCBI taxonomy Id: 1048834
Other names: A. acidocaldarius subsp. acidocaldarius Tc-4-1, Alicyclobacillus acidocaldarius subsp. acidocaldarius Tc-4-1, Alicyclobacillus acidocaldarius subsp. acidocaldarius str. Tc-4-1, Alicyclobacillus acidocaldarius subsp. acidocaldarius strain Tc-4-1
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