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aceA aceA pgi pgi glk glk sfcA sfcA prsA prsA TC41_0572 TC41_0572 acs acs icd icd lpd lpd aceF aceF pdhB pdhB pdhA pdhA fumA fumA pgk pgk tpiA tpiA gpm-2 gpm-2 eno eno TC41_0770 TC41_0770 gltA gltA ilvA ilvA pdhA-2 pdhA-2 bkdA2 bkdA2 aceF-2 aceF-2 hoxU hoxU pdhA-3 pdhA-3 pdhB-2 pdhB-2 acnA acnA tktA tktA gnd gnd serA serA serC serC acsA acsA sucC sucC sucD sucD mmsA mmsA acs-2 acs-2 icd-2 icd-2 fadN fadN ppdK ppdK glpX glpX gcvH gcvH folD folD TC41_1685 TC41_1685 accB accB gpm-3 gpm-3 gcvPB gcvPB gcvPA gcvPA gcvT gcvT caiD caiD paaH paaH sdhB sdhB sdhA sdhA sdhC sdhC TC41_1975 TC41_1975 rpiA rpiA TC41_2024 TC41_2024 such such accC accC TC41_2177 TC41_2177 atoB-3 atoB-3 fbaB fbaB pfk pfk ppc ppc sfcA-2 sfcA-2 mqo mqo sucB sucB sucA sucA gltA-2 gltA-2 gapA gapA eda eda kdgK kdgK TC41_2592 TC41_2592 mdh mdh icd-3 icd-3 pyk pyk accA accA accD accD cysK cysK cysE cysE aceB aceB zwf zwf glyA glyA talA talA fadJ fadJ gntK gntK gnd-2 gnd-2 folD-2 folD-2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
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gene neighborhood
gene fusions
gene co-occurrence
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aceAIsocitrate lyase. (427 aa)
pgiGlucose-6-phosphate isomerase. (426 aa)
glkGlucokinase, ROK family. (313 aa)
sfcAMalate dehydrogenase (oxaloacetate- decarboxylating). (503 aa)
prsARibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (314 aa)
TC41_0572Methylmalonate-semialdehyde dehydrogenase. (339 aa)
acsAMP-dependent synthetase and ligase. (573 aa)
icdIsocitrate/isopropylmalate dehydrogenase. (365 aa)
lpdDihydrolipoamide dehydrogenase. (470 aa)
aceFDihydrolipoyllysine-residue succinyltransferase. (435 aa)
pdhBTransketolase central region. (326 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (361 aa)
fumAHydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (508 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (403 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (256 aa)
gpm-2Phosphoglycerate mutase, 2,3-bisphosphoglycerate- independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (521 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa)
TC41_0770Hypothetical protein. (152 aa)
gltACitrate (Si)-synthase; Belongs to the citrate synthase family. (359 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (399 aa)
pdhA-2Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (370 aa)
bkdA2Transketolase central region. (324 aa)
aceF-2Dihydrolipoyllysine-residue succinyltransferase. (442 aa)
hoxUFormate dehydrogenase, alpha subunit. (994 aa)
pdhA-3Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (358 aa)
pdhB-2Transketolase central region. (325 aa)
acnAAconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (904 aa)
tktATransketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (671 aa)
gnd6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (480 aa)
serAD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (361 aa)
acsAacetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (684 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (398 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (299 aa)
mmsAMethylmalonate-semialdehyde dehydrogenase. (480 aa)
acs-2AMP-dependent synthetase and ligase. (548 aa)
icd-2Isocitrate dehydrogenase. (487 aa)
fadN3-hydroxyacyl-CoA dehydrogenase NAD-binding protein. (797 aa)
ppdKPyruvate, phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (895 aa)
glpXFructose-1,6-bisphosphatase, class II. (321 aa)
gcvHGlycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. (126 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa)
TC41_1685acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa)
accBacetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (151 aa)
gpm-3Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. (192 aa)
gcvPBGlycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (487 aa)
gcvPAGlycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (451 aa)
gcvTGlycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (370 aa)
caiDEnoyl-CoA hydratase/isomerase. (258 aa)
paaH3-hydroxybutyryl-CoA dehydrogenase. (253 aa)
sdhBSuccinate dehydrogenase and fumarate reductase iron-sulfur protein. (262 aa)
sdhASuccinate dehydrogenase or fumarate reductase, flavoprotein subunit. (596 aa)
sdhCSuccinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family. (206 aa)
TC41_19756-phosphogluconate dehydrogenase NAD-binding protein. (283 aa)
rpiARibose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (224 aa)
TC41_2024Formate dehydrogenase, alpha subunit. (986 aa)
suchBiotin/lipoyl attachment domain-containing protein. (64 aa)
accCCarbamoyl-phosphate synthase L chain ATP-binding protein. (446 aa)
TC41_2177AMP-dependent synthetase and ligase. (657 aa)
atoB-3acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
fbaBFructose-bisphosphate aldolase. (355 aa)
pfk6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (329 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (906 aa)
sfcA-2Malate dehydrogenase (oxaloacetate- decarboxylating). (474 aa)
mqoMalate/quinone oxidoreductase. (548 aa)
sucB2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase. (419 aa)
sucA2-oxoglutarate dehydrogenase, E1 subunit. (949 aa)
gltA-22-methylcitrate synthase/citrate synthase II; Belongs to the citrate synthase family. (377 aa)
gapAGlyceraldehyde-3-phosphate dehydrogenase, type I; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
eda2-dehydro-3-deoxyphosphogluconate aldolase/4- hydroxy-2-oxoglutarate aldolase. (208 aa)
kdgKPfkB domain protein. (351 aa)
TC41_2592Formamidase. (397 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (311 aa)
icd-3Isocitrate dehydrogenase, NADP-dependent. (432 aa)
pykPyruvate kinase; Belongs to the pyruvate kinase family. (472 aa)
accAacetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (299 aa)
cysKCysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (309 aa)
cysESerine O-acetyltransferase. (289 aa)
aceBMalate synthase A; Belongs to the malate synthase family. (534 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (520 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
talATransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (215 aa)
fadJEnoyl-CoA hydratase/isomerase; Belongs to the enoyl-CoA hydratase/isomerase family. (261 aa)
gntKCarbohydrate kinase FGGY; Belongs to the FGGY kinase family. (483 aa)
gnd-26-phosphogluconate dehydrogenase, decarboxylating. (299 aa)
folD-2Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (285 aa)
Your Current Organism:
Alicyclobacillus acidocaldarius Tc41
NCBI taxonomy Id: 1048834
Other names: A. acidocaldarius subsp. acidocaldarius Tc-4-1, Alicyclobacillus acidocaldarius subsp. acidocaldarius Tc-4-1, Alicyclobacillus acidocaldarius subsp. acidocaldarius str. Tc-4-1, Alicyclobacillus acidocaldarius subsp. acidocaldarius strain Tc-4-1
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