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leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (574 aa) | ||||
icd | Isocitrate/isopropylmalate dehydrogenase. (365 aa) | ||||
gltA | Citrate (Si)-synthase; Belongs to the citrate synthase family. (359 aa) | ||||
leuA-2 | 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (533 aa) | ||||
acnA | Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (904 aa) | ||||
argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (348 aa) | ||||
argB | Acetylglutamate kinase. (263 aa) | ||||
argD | Acetylornithine and succinylornithine aminotransferase. (389 aa) | ||||
argA | GCN5-related N-acetyltransferase. (162 aa) | ||||
lysC | Aspartate kinase; Belongs to the aspartokinase family. (414 aa) | ||||
asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (345 aa) | ||||
lysC-2 | Aspartate kinase, monofunctional class; Belongs to the aspartokinase family. (405 aa) | ||||
icd-2 | Isocitrate dehydrogenase. (487 aa) | ||||
gltA-2 | 2-methylcitrate synthase/citrate synthase II; Belongs to the citrate synthase family. (377 aa) | ||||
leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (202 aa) | ||||
leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (471 aa) | ||||
leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (359 aa) | ||||
ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (350 aa) | ||||
ilvH | Acetolactate synthase, small subunit. (176 aa) | ||||
ilvB | Acetolactate synthase, large subunit, biosynthetic type. (576 aa) | ||||
ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (557 aa) | ||||
ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (295 aa) | ||||
icd-3 | Isocitrate dehydrogenase, NADP-dependent. (432 aa) | ||||
aspB | Aminotransferase class I and II. (407 aa) |