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leuA leuA icd icd gltA gltA leuA-2 leuA-2 acnA acnA argC argC argB argB argD argD argA argA lysC lysC asd asd lysC-2 lysC-2 icd-2 icd-2 gltA-2 gltA-2 leuD leuD leuC leuC leuB leuB ilvC ilvC ilvH ilvH ilvB ilvB ilvD ilvD ilvE ilvE icd-3 icd-3 aspB aspB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (574 aa)
icdIsocitrate/isopropylmalate dehydrogenase. (365 aa)
gltACitrate (Si)-synthase; Belongs to the citrate synthase family. (359 aa)
leuA-22-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (533 aa)
acnAAconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (904 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (348 aa)
argBAcetylglutamate kinase. (263 aa)
argDAcetylornithine and succinylornithine aminotransferase. (389 aa)
argAGCN5-related N-acetyltransferase. (162 aa)
lysCAspartate kinase; Belongs to the aspartokinase family. (414 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (345 aa)
lysC-2Aspartate kinase, monofunctional class; Belongs to the aspartokinase family. (405 aa)
icd-2Isocitrate dehydrogenase. (487 aa)
gltA-22-methylcitrate synthase/citrate synthase II; Belongs to the citrate synthase family. (377 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (202 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (471 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (359 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (350 aa)
ilvHAcetolactate synthase, small subunit. (176 aa)
ilvBAcetolactate synthase, large subunit, biosynthetic type. (576 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (557 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (295 aa)
icd-3Isocitrate dehydrogenase, NADP-dependent. (432 aa)
aspBAminotransferase class I and II. (407 aa)
Your Current Organism:
Alicyclobacillus acidocaldarius Tc41
NCBI taxonomy Id: 1048834
Other names: A. acidocaldarius subsp. acidocaldarius Tc-4-1, Alicyclobacillus acidocaldarius subsp. acidocaldarius Tc-4-1, Alicyclobacillus acidocaldarius subsp. acidocaldarius str. Tc-4-1, Alicyclobacillus acidocaldarius subsp. acidocaldarius strain Tc-4-1
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