STRINGSTRING
purA purA guaB guaB AKK02374.1 AKK02374.1 guaA guaA purK purK purE purE AKK02587.1 AKK02587.1 AKK02641.1 AKK02641.1 purN purN purH purH AKK03182.1 AKK03182.1 gmk gmk AKK03269.1 AKK03269.1 apt apt purM purM purF purF purC purC purB purB purD purD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (508 aa)
AKK02374.1IMP dehydrogenase family protein. (382 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (507 aa)
purKPhosphoribosylaminoimidazole carboxylase, PurK protein; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (385 aa)
purEPhosphoribosylaminoimidazole carboxylase, PurE protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (166 aa)
AKK02587.1Phosphoribosylformylglycinamidine synthase, clade II. (1220 aa)
AKK02641.15'-nucleotidase/2',3'-cyclic phosphodiesterase-like hydrolase; Belongs to the 5'-nucleotidase family. (690 aa)
purNPhosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (191 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. (510 aa)
AKK03182.1GMP synthase family protein. (247 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (188 aa)
AKK03269.15'-nucleotidase/2',3'-cyclic phosphodiesterase-like hydrolase; Belongs to the 5'-nucleotidase family. (682 aa)
aptPRPP-binding protein, adenine/guanine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (182 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (357 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (510 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (297 aa)
purBAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (476 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (529 aa)
Your Current Organism:
Corynebacterium epidermidicanis
NCBI taxonomy Id: 1050174
Other names: C. epidermidicanis, CCUG 60915, Corynebacterium epidermidicanis Frischmann et al. 2012, Corynebacterium sp. DSM 45586, DSM 45586, LMG 26322, LMG:26322, strain 410
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