(58 nodes) Mixed, incl. Lagging Strand Synthesis, and Damaged DNA binding network (Verticillium nonalfalfae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	D7B24_004517	Uncharacterized protein. (393 aa)
	ATAD5	ATPase AAA domain-containing protein 5. (1213 aa)
	D7B24_003073	Uncharacterized protein. (461 aa)
	D7B24_002835	Uncharacterized protein. (193 aa)
	RAD10	SsDNA endonuclease and repair protein rad10. (414 aa)
	D7B24_002792	SAE2 domain-containing protein. (725 aa)
	D7B24_001960	3'-5' exonuclease domain-containing protein. (581 aa)
	DNA2	Tripartite DNA replication factor. (1623 aa)
	POLD2	DNA polymerase delta subunit 2. (503 aa)
	RAD54	DNA-dependent ATPase protein rad54. (859 aa)
	RAD50	DNA repair protein rad50. (1308 aa)
	RAD51	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (355 aa)
	D7B24_000881	DNA ligase. (860 aa)
	D7B24_009567	BRCT domain-containing protein. (262 aa)
	POL3	DNA polymerase. (1104 aa)
	TEL1	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (3104 aa)
	D7B24_009453	Uncharacterized protein. (109 aa)
	D7B24_008913	BRCT domain-containing protein. (1181 aa)
	PCN1	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	RFA1	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (617 aa)
	D7B24_008311	DNA ligase. (893 aa)
	RAD2	DNA repair protein rad2. (1223 aa)
	RAD1	SsDNA endodeoxyribonuclease. (326 aa)
	RFC2_2	Subunit of heteropentameric Replication factor C (RF-C). (361 aa)
	D7B24_009089	DNA_ligase_A_N domain-containing protein. (349 aa)
	D7B24_008797	Vezatin domain-containing protein. (615 aa)
	MEC1_1	Serine/threonine-protein kinase M1; Belongs to the PI3/PI4-kinase family. (2248 aa)
	D7B24_008170	Uncharacterized protein. (399 aa)
	D7B24_008031	Uncharacterized protein. (80 aa)
	RAD17	Cell cycle checkpoint protein rad17. (900 aa)
	RFA2	Replication factor A protein 2. (290 aa)
	D7B24_007801	UmuC domain-containing protein. (566 aa)
	D7B24_007076	Checkpoint protein; Belongs to the HUS1 family. (339 aa)
	D7B24_007211	Uncharacterized protein. (443 aa)
	D7B24_007126	UmuC domain-containing protein. (630 aa)
	D7B24_006651	AAA domain-containing protein. (945 aa)
	D7B24_006999	ERCC4 domain-containing protein. (951 aa)
	D7B24_005660	Uncharacterized protein. (146 aa)
	D7B24_005810	BRCT domain-containing protein. (1040 aa)
	D7B24_004605	HORMA domain-containing protein. (320 aa)
	D7B24_004505	XPA_C domain-containing protein. (393 aa)
	D7B24_004607	Uncharacterized protein. (123 aa)
	RFC5_2	Replication factor C (RF-C) subunit. (352 aa)
	D7B24_004435	RECA_2 domain-containing protein. (459 aa)
	D7B24_004840	Uncharacterized protein. (999 aa)
	RAD52	DNA repair protein rad52. (524 aa)
	D7B24_003634	XPGI domain-containing protein. (464 aa)
	MRE11	Meiotic recombination; Belongs to the MRE11/RAD32 family. (701 aa)
	RFC5_1	Replication factor C (RF-C) subunit. (391 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (394 aa)
	MUS81	Crossover junction endonuclease mus81. (591 aa)
	RAD30	DNA-directed DNA polymerase eta rad30. (660 aa)
	REV3L	DNA polymerase. (1686 aa)
	MPH1	3'-5' DNA helicase. (1128 aa)
	REV1	Deoxycytidyl transferase. (1184 aa)
	D7B24_005957	Uncharacterized protein. (458 aa)
	RFC2_1	Subunit of heteropentameric Replication factor C (RF-C). (380 aa)
	D7B24_004996	Endo/exonuclease/phosphatase domain-containing protein. (550 aa)

Your Current Organism:

Verticillium nonalfalfae

NCBI taxonomy Id: 1051616
Other names: CBS 130339, NRRL 54791, PD592, UC 1953898, V. nonalfalfae, Verticillium sp. PI-2011d

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	D7B24_000881	A0A3M9XX35	A0A3M9Y270	ATPase AAA domain-containing protein 5.	DNA ligase.	0.791
ATAD5	D7B24_001960	A0A3M9XX35	A0A3M9Y016	ATPase AAA domain-containing protein 5.	3'-5' exonuclease domain-containing protein.	0.998
ATAD5	D7B24_002835	A0A3M9XX35	A0A3M9XXX4	ATPase AAA domain-containing protein 5.	Uncharacterized protein.	0.442
ATAD5	D7B24_003073	A0A3M9XX35	A0A3M9XXH4	ATPase AAA domain-containing protein 5.	Uncharacterized protein.	0.748
ATAD5	D7B24_003634	A0A3M9XX35	A0A3M9YGN1	ATPase AAA domain-containing protein 5.	XPGI domain-containing protein.	0.801
ATAD5	D7B24_004435	A0A3M9XX35	A0A3M9YFM1	ATPase AAA domain-containing protein 5.	RECA_2 domain-containing protein.	0.747
ATAD5	D7B24_004505	A0A3M9XX35	A0A3M9YDK1	ATPase AAA domain-containing protein 5.	XPA_C domain-containing protein.	0.579
ATAD5	D7B24_004517	A0A3M9XX35	A0A3M9XW95	ATPase AAA domain-containing protein 5.	Uncharacterized protein.	0.690
ATAD5	D7B24_004605	A0A3M9XX35	A0A3M9YD98	ATPase AAA domain-containing protein 5.	HORMA domain-containing protein.	0.633
ATAD5	D7B24_004607	A0A3M9XX35	A0A3M9YEF4	ATPase AAA domain-containing protein 5.	Uncharacterized protein.	0.763
ATAD5	D7B24_004840	A0A3M9XX35	A0A3M9YFN3	ATPase AAA domain-containing protein 5.	Uncharacterized protein.	0.913
ATAD5	D7B24_004996	A0A3M9XX35	A0A3M9YMU6	ATPase AAA domain-containing protein 5.	Endo/exonuclease/phosphatase domain-containing protein.	0.711
ATAD5	D7B24_005660	A0A3M9XX35	A0A3M9YB88	ATPase AAA domain-containing protein 5.	Uncharacterized protein.	0.699
ATAD5	D7B24_005810	A0A3M9XX35	A0A3M9YC98	ATPase AAA domain-containing protein 5.	BRCT domain-containing protein.	0.580
ATAD5	D7B24_005957	A0A3M9XX35	A0A3M9YM18	ATPase AAA domain-containing protein 5.	Uncharacterized protein.	0.665
ATAD5	D7B24_006651	A0A3M9XX35	A0A3M9Y8U2	ATPase AAA domain-containing protein 5.	AAA domain-containing protein.	0.899
ATAD5	D7B24_006999	A0A3M9XX35	A0A3M9Y8Z1	ATPase AAA domain-containing protein 5.	ERCC4 domain-containing protein.	0.787
ATAD5	D7B24_007076	A0A3M9XX35	A0A3M9Y7Y5	ATPase AAA domain-containing protein 5.	Checkpoint protein; Belongs to the HUS1 family.	0.519
ATAD5	D7B24_007126	A0A3M9XX35	A0A3M9Y8H4	ATPase AAA domain-containing protein 5.	UmuC domain-containing protein.	0.640
ATAD5	D7B24_007211	A0A3M9XX35	A0A3M9Y8D8	ATPase AAA domain-containing protein 5.	Uncharacterized protein.	0.660