(16 nodes) Mixed, incl. Double-strand break repair via synthesis-dependent strand annealing, and Sensing of DNA Double Strand Breaks network (Verticillium nonalfalfae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	D7B24_004517	Uncharacterized protein. (393 aa)
	D7B24_001960	3'-5' exonuclease domain-containing protein. (581 aa)
	DNA2	Tripartite DNA replication factor. (1623 aa)
	RAD54	DNA-dependent ATPase protein rad54. (859 aa)
	RAD50	DNA repair protein rad50. (1308 aa)
	RAD51	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (355 aa)
	TEL1	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (3104 aa)
	D7B24_008913	BRCT domain-containing protein. (1181 aa)
	MEC1_1	Serine/threonine-protein kinase M1; Belongs to the PI3/PI4-kinase family. (2248 aa)
	D7B24_004435	RECA_2 domain-containing protein. (459 aa)
	D7B24_004840	Uncharacterized protein. (999 aa)
	RAD52	DNA repair protein rad52. (524 aa)
	D7B24_003634	XPGI domain-containing protein. (464 aa)
	MRE11	Meiotic recombination; Belongs to the MRE11/RAD32 family. (701 aa)
	MPH1	3'-5' DNA helicase. (1128 aa)
	D7B24_005957	Uncharacterized protein. (458 aa)

Your Current Organism:

Verticillium nonalfalfae

NCBI taxonomy Id: 1051616
Other names: CBS 130339, NRRL 54791, PD592, UC 1953898, V. nonalfalfae, Verticillium sp. PI-2011d

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
D7B24_001960	D7B24_003634	A0A3M9Y016	A0A3M9YGN1	3'-5' exonuclease domain-containing protein.	XPGI domain-containing protein.	0.999
D7B24_001960	D7B24_004435	A0A3M9Y016	A0A3M9YFM1	3'-5' exonuclease domain-containing protein.	RECA_2 domain-containing protein.	0.999
D7B24_001960	D7B24_004517	A0A3M9Y016	A0A3M9XW95	3'-5' exonuclease domain-containing protein.	Uncharacterized protein.	0.999
D7B24_001960	D7B24_004840	A0A3M9Y016	A0A3M9YFN3	3'-5' exonuclease domain-containing protein.	Uncharacterized protein.	0.981
D7B24_001960	D7B24_005957	A0A3M9Y016	A0A3M9YM18	3'-5' exonuclease domain-containing protein.	Uncharacterized protein.	0.999
D7B24_001960	D7B24_008913	A0A3M9Y016	A0A3M9Y3W7	3'-5' exonuclease domain-containing protein.	BRCT domain-containing protein.	0.998
D7B24_001960	DNA2	A0A3M9Y016	A0A3M9Y0J8	3'-5' exonuclease domain-containing protein.	Tripartite DNA replication factor.	0.999
D7B24_001960	MEC1_1	A0A3M9Y016	A0A3M9Y6J3	3'-5' exonuclease domain-containing protein.	Serine/threonine-protein kinase M1; Belongs to the PI3/PI4-kinase family.	0.999
D7B24_001960	MPH1	A0A3M9Y016	A0A3M9YLJ7	3'-5' exonuclease domain-containing protein.	3'-5' DNA helicase.	0.979
D7B24_001960	MRE11	A0A3M9Y016	A0A3M9YI20	3'-5' exonuclease domain-containing protein.	Meiotic recombination; Belongs to the MRE11/RAD32 family.	0.999
D7B24_001960	RAD50	A0A3M9Y016	A0A3M9Y1Z8	3'-5' exonuclease domain-containing protein.	DNA repair protein rad50.	0.998
D7B24_001960	RAD51	A0A3M9Y016	A0A3M9Y236	3'-5' exonuclease domain-containing protein.	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	0.999
D7B24_001960	RAD52	A0A3M9Y016	A0A3M9YGC2	3'-5' exonuclease domain-containing protein.	DNA repair protein rad52.	0.999
D7B24_001960	RAD54	A0A3M9Y016	A0A3M9Y177	3'-5' exonuclease domain-containing protein.	DNA-dependent ATPase protein rad54.	0.939
D7B24_001960	TEL1	A0A3M9Y016	A0A3M9Y377	3'-5' exonuclease domain-containing protein.	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	0.998
D7B24_003634	D7B24_001960	A0A3M9YGN1	A0A3M9Y016	XPGI domain-containing protein.	3'-5' exonuclease domain-containing protein.	0.999
D7B24_003634	D7B24_004435	A0A3M9YGN1	A0A3M9YFM1	XPGI domain-containing protein.	RECA_2 domain-containing protein.	0.789
D7B24_003634	D7B24_004517	A0A3M9YGN1	A0A3M9XW95	XPGI domain-containing protein.	Uncharacterized protein.	0.724
D7B24_003634	D7B24_004840	A0A3M9YGN1	A0A3M9YFN3	XPGI domain-containing protein.	Uncharacterized protein.	0.575
D7B24_003634	D7B24_005957	A0A3M9YGN1	A0A3M9YM18	XPGI domain-containing protein.	Uncharacterized protein.	0.731